Exploring the relationship of Vitamin D and childhood brain tumors

探索维生素 D 与儿童脑肿瘤的关系

• 批准号: 8429392
• 负责人: Parveen Bhatti
• 金额: $ 8.27万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-16 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8429392
• 关键词: Adult; Age-Months; Animals; Archives; Astrocytoma; Biological Markers; Birth Certificates; Birth Weight; Blood; Brain Neoplasms; Cancer Etiology; Case-Control Studies; Cessation of life; Child; Childhood; Childhood Brain Neoplasm; Cholecalciferol; Data; Databases; Development; Diagnostic; Disease; Ependymoma; Epidemiology; Ethnic Origin; Etiology; Fostering; Future; Gestational Age; Goals; Health; Histology; Human; Intervention; Lead; Link; Malignant Childhood Neoplasm; Malignant Neoplasms; Measurement; Measures; Mission; Neonatal; Neonatal Screening; Pathogenesis; Pregnancy; Pregnant Women; Primitive Neuroectodermal Tumor; Public Health; Race; Research; Research Personnel; Resources; Risk; Risk Factors; Specimen; Spottings; Temperature; Testing; Time; Vitamin D; Vitamin D Deficiency; Vitamin D2; Vitamins; aging brain; base; burden of illness; cancer risk; improved; in utero; innovation; insight; modifiable risk; neoplasm registry; population based; prenatal smoking; prevent; programs; season of birth; sex

DESCRIPTION (provided by applicant): Low circulating levels of vitamin D [25-(OH)D] have been associated with various adult onset cancers. However, studies of childhood cancer have not been conducted despite compelling experimental and epidemiologic evidence suggesting that reduced vitamin D during gestational development may be a risk factor, particularly for childhood brain tumors (CBT). For CBT, the in utero period of development has been shown to be a critical time window of exposure. Neonatal dried blood spots (DBS) collected and archived as part of newborn screening programs represent a unique resource for examining pre-diagnostic 25-(OH)D in relation to childhood cancers and allows for focus on the impact of vitamin D during the in utero time period. The long-term goal is to understand the pathogenesis of CBT so that interventions can be developed to reduce the burden of this disease among children. The overall objective for this application, which is a step toward attainment of the long term goal, is to examine the association between neonatal 25-(OH)D, as measured in DBS, with risk of CBT. The central hypothesis of the proposed study is that vitamin D deficiency during pregnancy is associated with increased risk of CBT. The hypothesis will be tested by pursuing two specific aims 1) Evaluate among 250 childhood brain tumor cases and 250 controls the association between 25-(OH)D, as measured in DBS as a marker of gestational circulating vitamin D levels, and the risk of CBT; 2) In exploratory analyses, determine if the association between 25-(OH)D and brain tumor risk differs by sex, race/ethnicity, prenatal smoking, maternal SES, brain tumor histology, birth weight, gestational age and month and season of birth. This study is innovative because it will, for the first time, examine circulating vitamin D levels as predictors of CBT risk by using measurements in DBS as markers of in utero vitamin D levels. The proposed research is significant because it is expected to provide valuable data that will ultimately lead to efficacious targets for interventions to mitigate the occurrence of CBT.

描述（由申请人提供）：低循环水平的维生素D [25-（OH）D]与各种成人发病癌症有关。然而，尽管有令人信服的实验和流行病学证据表明，妊娠期发育期间维生素D减少可能是一个风险因素，但尚未进行儿童癌症的研究，特别是儿童脑肿瘤（CBT）。对于CBT，子宫内发育期已被证明是暴露的关键时间窗口。作为新生儿筛查计划的一部分，收集和存档的新生儿干血斑（DBS）代表了检查与儿童癌症相关的诊断前25-（OH）D的独特资源，并允许重点关注维生素D在子宫内时间段的影响。长期目标是了解CBT的发病机制，以便制定干预措施，减少儿童的疾病负担。这项申请的总体目标是朝着实现长期目标迈出的一步， 长期目标是检查DBS中测量的新生儿25-（OH）D与CBT风险之间的关系。这项研究的中心假设是，怀孕期间维生素D缺乏与CBT风险增加有关。该假设将通过追求两个具体目标进行检验：1）在250例儿童脑肿瘤病例和250例对照组中评估25-（OH）D（在DBS中测量，作为妊娠循环维生素D水平的标志物）与CBT风险之间的关联; 2）在探索性分析中，确定25-（OH）D与脑肿瘤风险之间的关联是否因性别、种族/民族、产前吸烟、母亲SES而不同，脑肿瘤组织学、出生体重、胎龄、出生月份和季节。这项研究是创新的，因为它将首次通过使用DBS中的测量值作为子宫内维生素D水平的标志物来检查循环维生素D水平作为CBT风险的预测因子。拟议的研究是重要的，因为它有望提供有价值的数据，最终将导致有效的干预目标，以减轻CBT的发生。