Nightshift Work and DNA Methylation of Circadian Genes

夜班工作与昼夜节律基因的 DNA 甲基化

基本信息

  • 批准号:
    8636239
  • 负责人:
  • 金额:
    $ 22万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-12-01 至 2015-11-30
  • 项目状态:
    已结题

项目摘要

Project Summary With an estimated 15 to 20% of workers in North America and Europe engaged in nightshift work, the possibility that working at night can result in an increased risk of developing cancer is an important public health concern. Given the discrepancy between the strength of experimental and epidemiologic evidence for the carcinogenicity of nightshift work, studies of biomarkers of effect among nightshift workers can provide important new information regarding the possible etiologic link. The core circadian genes are essential for regulation of circadian rhythms and these genes are involved in a number of mechanisms important to carcinogenesis. Thus, differential expression of these genes, through modulation of DNA methylation, may be a mechanism by which nightshift workers are at an increased risk of developing cancer. The overall objective of this feasibility study is to determine whether differentially methylated sites can be detected in circadian genes between night and dayshift workers using existing samples from a carefully evaluated group of shift workers. This will be the first study with the capability to evaluate such differences in both men and women. The central hypothesis is that circadian disruption associated with working the nightshift results in differential expression of circadian genes that is manifest through differential methylation of loci in these genes. In addition, measures of adaptability to nightshift work, such as chronotype and sleep quality, will be evaluated for a potential impact on DNA methylation among nightshift workers. Using existing blood samples and questionnaire data, the study proposes to evaluate subjects who, at the time of blood draw, were actively working the nightshift for e1 year (n=230) and subjects who were actively working the dayshift for e1 year (n=114). The hypotheses will be tested by pursuing the following specific aims: 1) Evaluate differences in methylation at 334 loci in the 12 core circadian genes between established night and dayshift workers; 2) In exploratory analyses, evaluate if gender, race, chronotype and sleep quality affect the impact of nightshift work on DNA methylation at the 334 loci. This study will provide essential preliminary data for the pursuit of large scale investigations of epigenetic and other biomarkers among shift workers. Furthermore, the results of this study will be useful to the design of future epidemiologic studies examining cancer risk by providing data regarding the collection of the most relevant work history and sleep-related data, the incorporation of potentially useful biomarkers and the generation of new hypotheses. It is anticipated that this line of research will ultimately provide targets for interventions to mitigate negative health effects among nightshift workers.
项目摘要 据估计,北美和欧洲有15%至20%的工人从事夜班工作, 夜间工作可能会导致患癌症的风险增加,这是一个重要的公众问题。 健康问题。鉴于实验和流行病学证据之间的差异, 夜班工作的致癌性,研究夜班工人的生物标志物的影响,可以提供 关于可能的病因学联系的重要新信息。核心的昼夜节律基因对于 调节昼夜节律,这些基因参与了许多重要的机制, 致癌作用因此,这些基因的差异表达,通过调节DNA甲基化,可能是 这是夜班工人患癌症风险增加的一种机制。总体目标 这项可行性研究的目的是确定是否可以在昼夜节律中检测到差异甲基化位点。 基因之间的夜班和白班工人使用现有的样本,从一个仔细评估组的轮班 工人这将是第一项能够评估男女之间这种差异的研究。 中心假设是,与夜班工作相关的昼夜节律紊乱导致了差异性的 昼夜节律基因的表达通过这些基因中的基因座的差异甲基化而显现。在 此外,还将评估夜班工作的适应性措施,如时钟类型和睡眠质量, 对夜班工人DNA甲基化的潜在影响。使用现有的血液样本, 问卷调查数据,该研究建议评估受试者,在抽血时, 在e1年内上夜班的受试者(n=230)和在e1年内上白班的受试者 (n=114)。将通过追求以下具体目标来测试假设:1)评估 在12个核心昼夜节律基因中334个位点的甲基化在已建立的夜班和白班工人之间; 2)在 探索性分析,评估性别,种族,时钟类型和睡眠质量是否影响夜班工作的影响 在334个位点上的DNA甲基化。这项研究将为寻求大规模的 表观遗传学和其他生物标志物在轮班工人中的规模调查。此外,这一结果 这项研究将有助于设计未来的流行病学研究,通过提供数据来检查癌症风险 关于收集最相关的工作历史和睡眠相关数据, 潜在有用的生物标志物和新假说的产生。预计这一研究方向 最终将为减轻夜班工人的负面健康影响提供干预目标。

项目成果

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Parveen Bhatti其他文献

Parveen Bhatti的其他文献

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{{ truncateString('Parveen Bhatti', 18)}}的其他基金

The impact of prenatal exposure to persistent organic pollutants on kinetics of immune response to vaccines and sero-protection in infants
产前接触持久性有机污染物对婴儿疫苗免疫反应动力学和血清保护的影响
  • 批准号:
    9920719
  • 财政年份:
    2016
  • 资助金额:
    $ 22万
  • 项目类别:
Nightshift Work and DNA Methylation of Circadian Genes
夜班工作与昼夜节律基因的 DNA 甲基化
  • 批准号:
    8771439
  • 财政年份:
    2013
  • 资助金额:
    $ 22万
  • 项目类别:
Exploring the relationship of Vitamin D and childhood brain tumors
探索维生素 D 与儿童脑肿瘤的关系
  • 批准号:
    8429392
  • 财政年份:
    2012
  • 资助金额:
    $ 22万
  • 项目类别:
Exploring the relationship of Vitamin D and childhood brain tumors
探索维生素 D 与儿童脑肿瘤的关系
  • 批准号:
    8241359
  • 财政年份:
    2012
  • 资助金额:
    $ 22万
  • 项目类别:

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