North Central Cancer Treatment Group (NCCTG) Biospecimen Resource

描述（由申请人提供）：北中央癌症治疗小组（NCCTG）的使命是通过在社区环境中进行高质量的临床和转化研究来改善癌症患者的生存时间和生活质量。NCCTG成立的前提是，美国的癌症护理主要发生在社区实践环境中。因此，社区是测试癌症预防、诊断、治疗和对症管理新方法的最合适场所。自2003年以来，NCCTG已收到来自12，000多名患者的17，000多个肿瘤组织块，NCCTG已收到来自9，500多名患者的38，000多个体液生物标本。通常情况下，样本来自70%至90%的患者，约75%来自社区肿瘤研究中心。因此，可获得足够数量的代表临床试验参与者的标本，以回答相关实验室研究中提出的科学问题。NCCTG生物标本资源将通过提供来自NCCTG试验入组患者的上级生物标本来支持NCCTG的使命，这些生物标本1）经过充分和一致的注释，2）在优化的标准条件下采集，3）经过质量评估，4）在受控条件下储存，以便有效检索并分发给合格的研究人员。本申请的四个具体目标是：1）继续优化从NCCTG和其他合作组临床试验入组的患者中获得的生物标本的采集和注释; 2）维护生物标本采集、处理和储存的标准操作规程（SOP）; 3）应用新兴技术采集和处理生物标本;以及4）提供对资源的持续监督，并改善研究团体获得资源的营销和教育。NCCTG代表将积极参与集团银行业务委员会（GBC）的活动，在GBC中担任适当的领导角色，并执行GBC制定的政策。NCCTG致力于协调GBC流程，包括标准操作程序，促进资源，信息系统，以及在拟议的

DESCRIPTION (provided by applicant): The mission of the North Central Cancer Treatment Group (NCCTG) is to improve the duration and quality of life of cancer patients by performing high-quality clinical and translational research in the community setting. NCCTG was founded on the premise that cancer care in the U.S. occurs primarily in the community practice setting. Consequently, the community is the most appropriate venue for testing novel approaches to prevention, diagnosis, treatment, and symptomatic management of cancer. Since 2003, NCCTG has received more than 17,000 tumor tissue blocks from over 12,000 patients, and NCCTG has received over 38,000 body fluid biospecimens from more than 9,500 patients. Typically, specimens are received from 70 to 90% of patients from whom they are requested, and approximately 75% originate from community oncology sites. Consequently, specimens representative of the clinical trial participants are available in sufficient numbers to answer the scientific questions posed in the correlative laboratory studies. The NCCTG Biospecimen Resource will support the NCCTG mission by providing superior biospecimens from patients enrolled on NCCTG trials that 1) are fully and consistently annotated, 2) have been collected under optimized standard conditions, 3) have undergone quality assessment, and 4) are stored under controlled conditions allowing efficient retrieval for distribution to qualified researchers. The four specific aims of this application are: 1) to continue to optimize the collection and annotation of biospecimens obtained from patients enrolled on NCCTG and other cooperative group clinical trials; 2) to maintain standard operating procedures (SOPs) for collecting, processing and storing biospecimens; 3) to apply emerging technologies for collection and processing of biospecimens; and 4) to provide ongoing oversight to the resource and Improve marketing and education regarding access to the resource for the research community. NCCTG representatives will actively participate in Group Banking Committee (GBC) activities, will assume leadership roles within the GBC as appropriate, and will implement policies established by the GBC. NCCTG is committed to harmonization of GBC processes, including standard operating procedures, promotion of the resource, information systems, and development of new strategies during the proposed