North Central Cancer Treatment Group

北中央癌症治疗小组

• 批准号: 7933204
• 负责人: JAN C BUCKNER
• 金额: $ 22.5万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7933204
• 关键词: Advocate; Area; Biological; Cancer Biology; Cancer Control; Cancer Patient; Clinical; Clinical Research Associate; Clinical Trials; Collaborations; Communication; Community Clinical Oncology Program; Concept Review; Data Collection; Development; Discipline; Disease; Education; Goals; Individual; Laboratories; Laboratory Study; Lead; Leadership; Letters; Malignant neoplasm of gastrointestinal tract; Malignant neoplasm of lung; Methodology; Methods; Modality; Nature; North Central Cancer Treatment Group; Oncologic Nursing; Oncology Nurse; Operative Surgical Procedures; Outcome; Pathology; Patients; Phase; Process; Protocols documentation; Publications; Quality Control; Quality of life; Radiation Oncology; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Review Committee; Techniques; Translational Research; Work; anticancer research; base; cancer health disparity; cancer prevention; cancer therapy; improved; malignant breast neoplasm; medical specialties; member; multidisciplinary; neuro-oncology; novel therapeutics; programs; protocol development; quality assurance; research study; sample collection; statistics; symptom management; translational study; treatment trial; tumor

Description (provided by applicant): The specific aims of the North Central Cancer Treatment Group (NCCTG) are: 1. to improve the duration and quality of life of cancer patients by performing high-quality multidisciplinary cancer treatment trials, 2. to improve the understanding of cancer biology and the biological consequences of treatment by conducting relevant correlative laboratory studies in conjunction with the clinical trials, 3. to improve methods for performing clinical trials by analysis of patient, tumor, and treatment variables in association with clinical outcomes, and 4. to provide an infrastructure for studies of cancer prevention and symptom management. These aims are accomplished through the efforts of four Disease Committees (Breast Cancer, Gastrointestinal Cancer, Lung Cancer, and Neuro-oncology), three Discipline-oriented Scientific Committees (Novel Therapeutics, Quality of Life, and Cancer Control), three Modality Committees (Surgery, Radiation Oncology, and Pathology), Statistics, and five Core Function Committees (Audit, Oncology Nursing Board, Clinical Research Associate (CRA) Board, Cancer Health Disparities, and Patient Advocate). The Disease Committees are responsible for developing and implementing clinical and translational research studies for their respective disease entities in collaboration with Modality, Discipline-oriented Scientific, and Core Function Committees. Modality Committees provide scientific expertise to Disease and Discipline-oriented Scientific Committees, develop quality control standards and provide quality control for individual studies, promote member education and conduct research studies appropriate for their specialty. Discipline-oriented Scientific Committees provide scientific expertise to Disease and Modality Committees and conduct research studies appropriate for their respective disciplines. Core Function Committees assist in protocol development, conduct, and quality assurance appropriate to their areas of expertise. The Group Statistician designates a specific statistician to work with each committee on an ongoing basis to collaborate in letter of intent and concept development, study design, data collection, analysis, presentation and publication. Given the multidisciplinary nature of clinical and translational cancer research, productive communication and interactions among these committees is necessary in order to reach the scientific goals of the Group. The framework for these interactions within NCCTG is illustrated in Table 1, and is described in more detail within the research plans of individual committees. The overarching scientific priority for NCCTG is to conduct high-quality phase II and phase IIII clinical and translational studies appropriate for the community oncology setting. The Translational Research Coordinating Committee serves in an advisory capacity to Group leadership, including NCCTG Committee leaders. The purpose of the committee is to provide scientific and technical advice related to the development and implementation of translational research studies conducted by other committees. Members of the Translational Research Coordinating Concept review concept proposals and protocols in order to assess their scientific merit, recommend additional translational objectives that may be appropriate for a particular protocol, provide advice regarding appropriate laboratory methodology, and identify emerging themes among individual committees that will lead to collaborations among separate committees. Dr. Wilma Lingle, co-director of the NCCTG Biospecimen Resource, also serves on the Translational Research Coordinating Committee and reviews concepts and protocols with translational aims to provide advice concerning appropriate specimen collection, processing techniques, and transport.

描述(申请人提供)：北中癌症治疗小组(NCCTG)的具体目标是：1.通过进行高质量的多学科癌症治疗试验来改善癌症患者的持续时间和生活质量，2.通过结合临床试验进行相关的实验室研究，提高对癌症生物学和治疗的生物学后果的了解，3.通过分析患者、肿瘤和治疗变量与临床结果相关联，改进临床试验的实施方法，以及4.为癌症预防和症状管理的研究提供基础设施。这些目标是通过四个疾病委员会(乳腺癌、胃肠癌、肺癌和神经肿瘤学)、三个面向学科的科学委员会(新疗法、生活质量和癌症控制)、三个医疗保健委员会(外科、放射肿瘤学和病理学)、统计学和五个核心职能委员会(审计、肿瘤护理委员会、临床研究助理委员会、癌症健康差异和患者倡导者)的努力实现的。疾病委员会负责与医疗、以学科为导向的科学和核心职能委员会合作，为各自的疾病实体开发和实施临床和转化性研究研究。医疗模式委员会向疾病和以学科为导向的科学委员会提供科学专门知识，制定质量控制标准，为个别研究提供质量控制，促进成员教育，并开展适合其专业的研究研究。以学科为导向的科学委员会向疾病和模式委员会提供科学专门知识，并进行适合其各自学科的研究。核心职能委员会协助制定与其专业领域相适应的礼仪、行为和质量保证。该小组统计员指定一名具体的统计员与每个委员会持续合作，在意向书和概念制定、研究设计、数据收集、分析、陈述和出版方面进行合作。鉴于临床和转化性癌症研究的多学科性质，这些委员会之间的富有成效的沟通和互动是必要的，以实现该小组的科学目标。NCCTG内部这些互动的框架如表1所示，并在各委员会的研究计划中作了更详细的说明。NCCTG的首要科学优先事项是进行适合社区肿瘤学环境的高质量的II期和III期临床和翻译研究。翻译研究协调委员会为包括NCCTG委员会领导人在内的集团领导层提供咨询服务。该委员会的目的是就其他委员会进行的翻译研究的发展和实施提供科学和技术咨询。翻译研究协调概念委员会成员审查概念提案和议定书，以评估其科学价值，建议可能适用于特定议定书的其他翻译目标，就适当的实验室方法提供建议，并确定将导致不同委员会之间合作的各个委员会之间的新主题。NCCTG生物标本资源联合主任Wilma Lingle博士也在翻译研究协调委员会任职，并审查概念和方案，以翻译为目的，就适当的标本收集、加工技术和运输提供建议。