Biostatistics and Bioinformatics

胃肠道生物统计和生物信息学核心(GI-BBC)的目标是为GI孢子提供广泛、高质量的统计和生物信息学支持。GI-BBC的主要目的是协助GI孢子研究人员设计、进行和分析本孢子应用中提出的实验室和临床研究。GI-BBC将致力于协助临床和实验室研究人员将他们的临床前研究转化为临床研究，通过统计咨询提供最先进的实验设计和分析，并在临床和实验室研究的方法学、可行性、分析和报告方面进行合作。此外，GI-BBC将作为所有GI-孢子调查人员的持续资源。中心将由克莱因博士领导，并增加三名教职员工作为联合调查员：王浩博士、雷切尔·卡钦博士和加里·罗斯纳博士。这些GI-BBC教职员工拥有互补的专业领域：克莱恩博士在流行病学和统计遗传学方面。罗斯纳博士从事生物统计学和临床试验。王博士从事临床试验和纵向建模，Karchin博士从事计算遗传学研究。癌症中心的生物统计学家Marianna Zahurak女士将协助Klein、Rosner和Wang博士进行统计分析。将统计需求集中在全球基础设施--英国广播公司的核心部门内，将使孢子调查员能够自由接触一组统计人员，掌握以具有成本效益的方式实现孢子当前和未来目标所需的一整套技能。此外，它还将促进孢子项目之间的交流，帮助将研究成果转化为临床环境。

The goal of the Gastrointestinal Biostatistics and Bioinformatics Core (GI-BBC) is to provide wide-ranging, high-quality statistical and bioinformatics support to the GI SPORE. The primary aim of the GI-BBC is to assist GI SPORE investigators in the design, conduct and analysis of laboratory and clinical studies proposed in this SPORE application. The GI-BBC will focus its efforts on assisting both the clinical and laboratory investigators in translating their pre-clinic studies into clinical studies by providing state-of-the-art experimental designs and analyses through statistical consultation and in collaboration with respect to methodology, feasibility, analysis, and reporting of clinical and laboratory studies. In addition, the GI-BBC will serve as an ongoing resource for all GI-SPORE Investigators. The Core will be led by Dr. Klein and staffed with three additional faculty members as co-investigators: Drs. Hao Wang, Rachel Karchin, and Gary Rosner. These GI-BBC faculty members have complementary areas of expertise: Dr. Klein in epidemiology and statistical genetics. Dr. Rosner in biostatistics and clinical trials. Dr. Wang in clinical trials and longitudinal modeling, and Dr. Karchin in computational genetics. Ms. Marianna Zahurak, a biostatistician in the Cancer Center, will assist Drs. Klein, Rosner, and Wang in statistical analyses. Centralization of statistical needs within the GI-BBC core will provide SPORE investigators with open access to a team of statisticians with the skill set necessary to meet the current and future goals of the SPORE in a cost-effective manner. In addition, it will facilitate communication across SPORE projects, aiding the translation of research findings into the clinical setting.