Genetics Core

遗传学核心

• 批准号: 8379365
• 负责人: ROBERT DAVID SCHREIBER
• 金额: $ 23.36万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8379365
• 关键词: Alleles; Backcrossings; Bioinformatics; Communities; Core Facility; Custom; Development; Genetic; Genetic Services; Genomics; Genotype; Growth; Human; Knockout Mice; Microinjections; Mouse Strains; Mus; Proteins; Research; Research Personnel; Rheumatism; Services; Speed; Techniques; Testing; Transgenic Mice; Transgenic Organisms; Universities; Washington; congenic; design; embryonic stem cell; member; tool

The Genetics Core facility is one of the research cores in the Rheumatic Diseases Core Center (RDCC) at Washington University. It proposes the following Specific Aims to sustain and develop new state-of-the-art protein services to RDCC members: 1) Support continued progress and growth of the Transgenic and Knockout Mouse Facility; 2) Support continued progress and growth of the mouse Speed Congenics Facility; and 3) Support development and use of a new Human Genomics and Bioinformatics Facility. The Transgenic and Knockout Mouse Facility helps RDCC investigators produce new strains of mice by microinjection of transgenic constructs or embryonic stem cells. The Speed Congenics Facility provides custom genotyping to speed backcrossing of mice with defined alleles onto homogeneous genetic backgrounds. The new Human Genomics and Bioinformatics Facility will provide expertise in design and interpretation of high throughput genetics information. All units are devoted to testing new techniques in order to provide the RDCC community with new tools.

遗传学核心设施是华盛顿大学风湿病核心中心（RDCC）的研究核心之一。它提出了以下具体目标，以维持和开发新的最先进的蛋白质服务RDCC成员：1）支持转基因和敲除小鼠设施的持续进步和增长; 2）支持小鼠速度同源性设施的持续进步和增长;和3）支持开发和使用新的人类基因组学和生物信息学设施。转基因和敲除小鼠设施帮助RDCC研究人员通过显微注射转基因结构或胚胎干细胞来生产新的小鼠品系。Speed Congenics Facility提供定制基因分型，以加速具有确定等位基因的小鼠与同质遗传背景的回交。新的人类基因组学和生物信息学设施将提供设计和解释高通量遗传学信息的专门知识。所有单位都致力于测试新技术，以便为RDCC社区提供新工具。