Combined Digital X-Ray, Optical, and Ultrasound Breast Imaging

组合数字 X 射线、光学和超声乳腺成像

• 批准号: 7921860
• 负责人: PAUL L CARSON
• 金额: $ 85.39万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7921860
• 关键词: Accounting; Acoustics; Address; Age; Animals; Anisotropy; Area; Arts; Biopsy; Blood; Blood Volume; Breast; Breast Cancer Detection; Callback; Characteristics; Chest wall structure; Clinical; Clinical Trials; Collimator; Color; Communication; Complex; Computer Systems Development; Computer software; Contrast Media; Coupling; Detection; Development; Devices; Diagnosis; Diagnostic; Digital Mammography; Digital Ray; Digital X-Ray; Distal; Doppler Ultrasound; Evaluation; Face; Fiber; Frequencies; Future; Gel; Goals; Hemoglobin; Human; Hybrids; Hypoxia; Image; Image Analysis; Imagery; Imaging Device; Investigation; Lasers; Length; Light; Location; Malignant Neoplasms; Mammary Ultrasonography; Mammography; Medical Imaging; Methods; Modality; Modification; Molecular; Motion; Nipples; Operating System; Optics; Patients; Pattern; Performance; Physicians; Physiologic pulse; Population; Positioning Attribute; Preparation; Procedures; Reader; Reading; Reporting; Research; Resolution; Role; Scanning; Schedule; Screening procedure; Sensitivity and Specificity; Side; Signal Transduction; Simulate; Solid; Specimen; Speed; Structure; System; Tail; Technology; Testing; Tissues; Transducers; Tube; Ultrasonic Transducer; Ultrasonography; Variant; Venous; Woman; Work; absorption; angiogenesis; anticancer research; cancer imaging; computerized data processing; design; detector; digital; experience; hemodynamics; imaging modality; improved; in vivo; interest; malignant breast neoplasm; meetings; multimodality; optical imaging; outcome forecast; polyvinylidene fluoride; pre-clinical; prototype; public health relevance; reconstruction; spectroscopic imaging; tissue phantom; tomography; tumor; volunteer

DESCRIPTION (provided by applicant): In the next decade, breast cancer screening will likely be some combination of x-ray, ultrasound (US) and/or optical imaging, if this combination can be performed efficiently. Towards this goal, a proof-of-concept multimodality system is proposed in which, x-ray, US and optical breast images are all acquired in the same mammographic geometry, making it possible to directly compare the complex patterns of the US and optical images with those patterns in a 3D version of mammography, digital tomosynthesis mammography (DTM), where there is, from its similarity with mammography, a great wealth of experience. It is hypothesized that with this system, not only will it be possible to reap the direct benefits of mammographic/US/optical co-localization but also to achieve superior image quality and diagnostic information from the combination of these modes. Spectroscopic photoacoustic tomography (S-PAT) is a promising imaging approach, with contrast provided by red and near infrared light absorption and with high resolution and sensitivity provided by the thermoacoustic signal detection from US transducers. These transducers will be specialized, broadband arrays allowing for synthetic aperture formation. Further enhancing sensitivity will be the short optical path lengths from both, compressed, sides of the breast. The potential for high resolution imaging of endogenous contrast, oxy and deoxy-hemoglobin, and, in the future, of targeted exogenous optical contrast agents warrants the substantial development and investigation that is proposed. This system brings the endogenous contrast imaging of S-PAT to practical test, coincident with state-of-the-art competitive and complimentary imaging modes, including US color flow Doppler imaging for comparison with S-PAT. The x-ray DTM system in the current BRP offers capabilities well beyond those of other research and clinical prototypes. The ultrasound in this combined system is meeting the goal of producing good images in essentially the same view as the x-rays and with good patient acceptance. Since the first submission of this renewal proposal, several concerns about the practical clinical performance of automated US scanning of the compressed breast have been investigated. They should be well resolved with the developments of a proposed tilting mesh compression paddle and an efficient acoustic coupling gel distribution system. With these further developments, the system will be ready to address a very serious question, the feasibility of using the first two modes of this system, DTM and automated US (AUS), for breast cancer screening. A large preliminary trial is proposed starting in the second year to demonstrate feasibility of frequent studies with the combined system and to evaluate the following questions in a callback-enriched screening study: 1) whether combined DTM/AUS will result in fewer callbacks than conventional mammography screening; and 2) whether the sensitivity of the combined system will increase significantly from the 72% historical rate for typical modern mammography practice. PUBLIC HEALTH RELEVANCE: The near future of breast imaging includes a 3D version of mammography (digital tomosynthesis mammography or DTM) in combination with ultrasound imaging. This project will marry DTM and mammography to automated ultrasound scanning and a new, optical imaging method "spectroscopic photoacoustic tomography", producing a combined system that will allow rapid comparison of any tissues in one image volume with the corresponding location in the other two image volumes. The system will be tested in simulated screening for provision of increased sensitivity to cancer with fewer unnecessary recalls for further imaging and biopsies.

描述（由申请人提供）：在接下来的十年中，乳腺癌筛查可能会是 X 射线、超声（US）和/或光学成像的某种组合，如果这种组合可以有效地进行的话。为了实现这一目标，提出了一种概念验证多模态系统，其中 X 射线、超声和光学乳腺图像均在相同的乳房 X 线摄影几何结构中采集，从而可以直接将超声和光学图像的复杂图案与 3D 版本的乳房 X 线摄影、数字断层合成乳房 X 线摄影 (DTM) 中的图案进行直接比较，其中由于与乳房 X 线摄影的相似性，因此具有丰富的经验。据推测，通过该系统，不仅可以获得乳腺X线摄影/超声/光学共定位的直接好处，而且还可以从这些模式的组合中获得卓越的图像质量和诊断信息。光谱光声断层扫描 (S-PAT) 是一种很有前途的成像方法，其对比度由红光和近红外光吸收提供，并且由 US 传感器的热声信号检测提供高分辨率和灵敏度。这些换能器将是专用的宽带阵列，可形成合成孔径。进一步增强灵敏度的是乳房两侧受压的光路长度较短。内源性造影剂、氧合血红蛋白和脱氧血红蛋白以及未来靶向外源性光学造影剂的高分辨率成像的潜力保证了所提出的实质性开发和研究。该系统将 S-PAT 的内源对比成像带入实际测试，与最先进的竞争和互补成像模式相一致，包括用于与 S-PAT 进行比较的美国彩色血流多普勒成像。当前 BRP 中的 X 射线 DTM 系统提供的功能远远超出其他研究和临床原型。该组合系统中的超声波满足了在与 X 射线基本相同的视图中产生良好图像的目标，并且获得了良好的患者接受度。自首次提交该更新提案以来，人们对压缩乳房自动超声扫描的实际临床性能的一些担忧进行了调查。通过开发所提出的倾斜网状压缩桨和高效的声耦合凝胶分配系统，应该可以很好地解决这些问题。随着这些进一步的发展，该系统将准备好解决一个非常严重的问题，即使用该系统的前两种模式（DTM 和自动化 US (AUS)）进行乳腺癌筛查的可行性。建议从第二年开始进行一项大型初步试验，以证明使用组合系统进行频繁研究的可行性，并评估回调丰富筛查研究中的以下问题：1）组合 DTM/AUS 是否会导致比传统乳房 X 线摄影筛查更少的回调； 2) 组合系统的灵敏度是否会比典型现代乳房 X 光检查实践的 72% 历史灵敏度显着提高。 公共健康相关性：不久的将来，乳腺成像包括 3D 版本的乳房 X 线摄影（数字断层合成乳房 X 线摄影或 DTM）与超声成像的结合。该项目将 DTM 和乳腺 X 线摄影与自动超声扫描和一种新的光学成像方法“光谱光声断层扫描”结合起来，产生一个组合系统，可以快速比较一个图像体积中的任何组织与其他两个图像体积中的相应位置。该系统将在模拟筛查中进行测试，以提高对癌症的敏感性，并减少不必要的进一步成像和活检的召回。