Combined Digital X-Ray, Optical, and Ultrasound Breast Imaging

组合数字 X 射线、光学和超声乳腺成像

• 批准号: 7527524
• 负责人: PAUL L CARSON
• 金额: $ 86.99万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-27 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7527524
• 关键词: Accounting; Acoustics; Address; Age; Animals; Anisotropy; Area; Arts; Biopsy; Blood; Blood Volume; Breast; Breast Cancer Detection; Callback; Characteristics; Chest wall structure; Clinical; Clinical Trials; Collimator; Color; Communication; Complex; Computer Systems Development; Computer software; Contrast Media; Coupling; Detection; Development; Devices; Diagnosis; Diagnostic; Digital Mammography; Digital Ray; Digital X-Ray; Distal; Doppler Ultrasound; Evaluation; Face; Fiber; Frequencies; Future; Gel; Goals; Hemoglobin; Human; Hybrids; Hypoxia; Image; Image Analysis; Imagery; Imaging Device; Investigation; Lasers; Length; Light; Location; Malignant Neoplasms; Mammary Ultrasonography; Mammography; Medical Imaging; Methods; Modality; Modification; Molecular; Motion; Multimodal Imaging; Nipples; Numbers; Operating System; Optics; Patients; Pattern; Performance; Personal Satisfaction; Physicians; Physiologic pulse; Population; Positioning Attribute; Preparation; Procedures; Public Health Practice; Pulse taking; Rate; Reader; Reading; Reporting; Research; Resolution; Role; Scanning; Schedule; Screening procedure; Sensitivity and Specificity; Side; Signal Transduction; Simulate; Solid; Specimen; Speed; Structure; System; Tail; Technology; Testing; Tissues; Transducers; Tube; Ultrasonic Transducer; Ultrasonography; Variant; Venous; Woman; Work; absorption; angiogenesis; anticancer research; cancer imaging; computerized data processing; concept; design; detector; digital; experience; hemodynamics; human study; improved; in vivo; interest; malignant breast neoplasm; optical imaging; outcome forecast; polyvinylidene fluoride; pre-clinical; prototype; reconstruction; spectroscopic imaging; tissue phantom; tomography; tumor; volunteer

DESCRIPTION (provided by applicant): In the next decade, breast cancer screening will likely be some combination of x-ray, ultrasound (US) and/or optical imaging, if this combination can be performed efficiently. Towards this goal, a proof-of-concept multimodality system is proposed in which, x-ray, US and optical breast images are all acquired in the same mammographic geometry, making it possible to directly compare the complex patterns of the US and optical images with those patterns in a 3D version of mammography, digital tomosynthesis mammography (DTM), where there is, from its similarity with mammography, a great wealth of experience. It is hypothesized that with this system, not only will it be possible to reap the direct benefits of mammographic/US/optical co-localization but also to achieve superior image quality and diagnostic information from the combination of these modes. Spectroscopic photoacoustic tomography (S-PAT) is a promising imaging approach, with contrast provided by red and near infrared light absorption and with high resolution and sensitivity provided by the thermoacoustic signal detection from US transducers. These transducers will be specialized, broadband arrays allowing for synthetic aperture formation. Further enhancing sensitivity will be the short optical path lengths from both, compressed, sides of the breast. The potential for high resolution imaging of endogenous contrast, oxy and deoxy-hemoglobin, and, in the future, of targeted exogenous optical contrast agents warrants the substantial development and investigation that is proposed. This system brings the endogenous contrast imaging of S-PAT to practical test, coincident with state-of-the-art competitive and complimentary imaging modes, including US color flow Doppler imaging for comparison with S-PAT. The x-ray DTM system in the current BRP offers capabilities well beyond those of other research and clinical prototypes. The ultrasound in this combined system is meeting the goal of producing good images in essentially the same view as the x-rays and with good patient acceptance. Since the first submission of this renewal proposal, several concerns about the practical clinical performance of automated US scanning of the compressed breast have been investigated. They should be well resolved with the developments of a proposed tilting mesh compression paddle and an efficient acoustic coupling gel distribution system. With these further developments, the system will be ready to address a very serious question, the feasibility of using the first two modes of this system, DTM and automated US (AUS), for breast cancer screening. A large preliminary trial is proposed starting in the second year to demonstrate feasibility of frequent studies with the combined system and to evaluate the following questions in a callback-enriched screening study: 1) whether combined DTM/AUS will result in fewer callbacks than conventional mammography screening; and 2) whether the sensitivity of the combined system will increase significantly from the 72% historical rate for typical modern mammography practice. PUBLIC HEALTH RELEVANCE: The near future of breast imaging includes a 3D version of mammography (digital tomosynthesis mammography or DTM) in combination with ultrasound imaging. This project will marry DTM and mammography to automated ultrasound scanning and a new, optical imaging method "spectroscopic photoacoustic tomography", producing a combined system that will allow rapid comparison of any tissues in one image volume with the corresponding location in the other two image volumes. The system will be tested in simulated screening for provision of increased sensitivity to cancer with fewer unnecessary recalls for further imaging and biopsies.

描述（由申请人提供）：在未来十年，乳腺癌筛查将可能是X射线，超声（US）和/或光学成像的某种组合，如果这种组合可以有效地进行。为了实现这一目标，提出了一种多模态概念验证系统，其中，X射线、US和光学乳房图像都在相同的乳房X线摄影几何结构中采集，使得可以直接将US和光学图像的复杂图案与乳房X线摄影的3D版本、数字断层合成乳房X线摄影（DTM）中的那些图案进行比较，其中，由于其与乳房X线摄影的相似性，存在大量的经验。据推测，使用该系统，不仅可以获得乳房X线摄影/US/光学共定位的直接益处，还可以通过这些模式的组合实现上级图像质量和诊断信息。光谱光声层析成像（S-PAT）是一种很有前途的成像方法，具有由红光和近红外光吸收提供的对比度，以及由US换能器的热声信号检测提供的高分辨率和灵敏度。这些传感器将是专门的宽带阵列，允许合成孔径的形成。进一步增强灵敏度将是来自乳房的两个压缩侧的短光程长度。内源性造影剂、氧合血红蛋白和脱氧血红蛋白的高分辨率成像的潜力，以及将来靶向外源性光学造影剂的潜力，保证了所提出的实质性开发和研究。该系统将S-PAT的内源性造影成像带入实际测试，与最先进的竞争和补充成像模式相一致，包括US彩色血流多普勒成像，用于与S-PAT进行比较。当前BRP中的X射线DTM系统提供的功能远远超出其他研究和临床原型。该组合系统中的超声波满足在与X射线基本相同的视图中产生良好图像的目标，并且具有良好的患者接受度。自首次提交该更新提案以来，已研究了有关压迫乳房自动US扫描实际临床性能的几个问题。这些问题应该随着所提出的倾斜网格压缩桨和有效的声学耦合凝胶分布系统的发展而得到很好的解决。随着这些进一步的发展，该系统将准备好解决一个非常严肃的问题，即使用该系统的前两种模式（DTM和自动US（AUS））进行乳腺癌筛查的可行性。建议在第二年开始一项大型初步试验，以证明使用组合系统进行频繁研究的可行性，并评估回调富集筛查研究中的以下问题：1）组合DTM/AUS是否会导致比传统乳腺X线摄影筛查更少的回调;以及2）组合系统的灵敏度是否将从典型的现代乳房X线摄影实践的72%的历史比率显著增加。 公共卫生相关性：在不久的将来，乳腺成像包括3D版本的乳腺X射线摄影（数字断层合成乳腺X射线摄影或DTM）与超声成像的组合。该项目将DTM和乳房X线摄影与自动超声扫描和一种新的光学成像方法“光谱光声断层扫描”结合起来，产生一种组合系统，可以快速比较一个图像体积中的任何组织与其他两个图像体积中的相应位置。该系统将在模拟筛查中进行测试，以提高对癌症的敏感性，减少进一步成像和活检的不必要召回。