INTERACT: a randomised trial of intensive blood pressure lowering in acute intracerebral haemorrhage

脑出血（ICH）是一种严重的中风，每年影响数千名澳大利亚人和世界上2-3百万人，其中大多数人死亡或致残。目前尚无有效的治疗方法，尽管有时可以手术治疗，早期注射特殊的凝血因子可能会改善预后。一种潜在的简单疗法是快速控制血压升高（BP），这在ICH中很常见，并预示着不良结局，可能是通过增加出血和脑肿胀。对于ICH中血压升高的最佳管理存在很大的不确定性。这项研究称为INTERACT，旨在确定在澳大利亚-亚洲100个临床研究中心随机分配的2000例ICH患者中早期快速降压管理策略的获益和风险平衡。

Intracerebral haemorrhage (ICH) is a serious type of stroke affecting thousands of Australians and 2-3 million people in the world each year, with most either dying or left disabled. There is no proven treatment for ICH, although surgery is sometimes used and early injection of a special clotting factor may improve outcome. One potential simple therapy is the rapid control of elevated blood pressure (BP) which occurs commonly and predicts a poor outcome in ICH, possibly by increasing bleeding and swelling in the brain. There is much uncertainty as to the optimal management of elevated BP in ICH. This study, called INTERACT, aims to determine the balance of benefits and risks of a management strategy of early rapid BP lowering in 2000 patients with ICH randomised from 100 clinical sites in Australia-Asia.