Intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine plus dihydroartemisinin-piperaquine to reduce adverse pregnancy outcomes and prevent malaria in Papua New Guinea: a randomised controlled trial

在巴布亚新几内亚，用磺胺多辛-乙胺嘧啶加双氢青蒿素-哌喹对妊娠期进行间歇性预防治疗，以减少不良妊娠结局并预防疟疾：一项随机对照试验

• 批准号: nhmrc : 2000780
• 金额: $ 293.85万
• 依托单位国家: 澳大利亚
• 项目类别: Clinical Trials and Cohort Studies Grants
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://researchdata.edu.au/intermittent-preventive-treatment-controlled-trial/1780908
• 关键词: Intermittent; preventive; treatment; pregnancy; sulphadoxine

Millions of pregnancies are complicated by malaria worldwide. Monthly sulphadoxine-pyrimethamine (SP) treatments, the current treatment strategy, no longer protects from malaria but improves birth outcomes through non-malarial effects. Dihydroartemisinin-piperaquine clears malaria but babies are smaller compared to women who received SP. A clinical trial of their combination has potential to substantially improve health outcomes for women and babies in Papua New Guinea and beyond.

全世界有数百万孕妇因疟疾而并发症。目前的治疗战略-每月一次的磺胺嘧啶-乙胺嘧啶治疗，不再能预防疟疾，而是通过非疟疾效应改善生育结果。双氢青蒿素-哌喹可以清除疟疾，但与接受SP的妇女相比，婴儿要小一些。对它们组合的临床试验有可能大大改善巴布亚新几内亚及其他地区妇女和婴儿的健康状况。