Near Infrared Detector for Advanced Ophthalmology
用于高级眼科的近红外探测器
基本信息
- 批准号:8393854
- 负责人:
- 金额:$ 71.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-01 至 2014-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAlabamaBackCalibrationChoroidal NeovascularizationClinical ResearchCommercial SectorsComputer InterfaceComputer softwareConfocal MicroscopyCustomData AnalysesDegenerative MyopiaDetectionDevelopmentDiagnosisDiagnostic ImagingDisease ProgressionEarly DiagnosisElectronicsEvaluationEyeFeedbackFundingFutureGoalsHealth SciencesHumanImageImaging technologyIndividualInfrared RaysLasersLifeLightLightingMacular degenerationMeasuresMicroscopicMyopiaNoiseOphthalmologyOphthalmoscopesOphthalmoscopyOpticsPathogenesisPatientsPerformancePhasePhotoreceptorsPopulationPrimatesPsychophysicsRadiation MonitoringResearchResolutionRetinaRetinalRetinal ConeRetinal DiseasesSafetySamplingScanningScientistSignal TransductionSolutionsSourceSpecialistSpeedStimulusStructureSystemTechniquesTemperatureThree-Dimensional ImagingTimeTissuesTreatment EfficacyUniversitiesVendorWorkabsorptionadaptive opticsdata acquisitiondensitydesigndetectorhuman subjectimaging modalityimprovedin vivoinnovative technologiesinstrumentmaculamonitoring devicenext generationnoveloperationphotoreceptor degenerationprogramsresponseretina blood vessel structuretoolvisual neurosciencevoltage
项目摘要
DESCRIPTION (provided by applicant): Some of the most useful tools for diagnosis and understanding of blinding retinal diseases rely on the use of spectral reflectance. Improvements to these tools, especially over the past decade, have greatly advanced our ability to achieve extremely high-resolution images of the human retina. In particular, scanning laser ophthalmoscopy has proven to be an important technique for studies of microperimetry, psychophysics and visual neuroscience by imaging the cone mosaic while simultaneously delivering stimuli to single cones. Due to the unprecedented resolution now achieved during retinal imaging, there is an increasing need for using longer wavelength light that can penetrate deeper into tissue and is invisible or imperceptible to the human eyes. Bounded by human eye response and increased optical absorption, the use of wavelengths between 900 and 1100 nm is the most suitable solution. Unfortunately, while there are several vendors providing decent light sources across this wavelength range there are no suitable photodetectors. Therefore, the goal of this proposed research effort is to develop an avalanche photodiode (APD) module with exceptional response from the visible to 1050 nm that will be compatible with established scanning laser ophthalmoscopes. Our proposed solution uses our APD's high responsivity to near-infrared radiation to develop a receiver module useful for ophthalmoscopy and other health sciences. In Phase I, we successfully demonstrated the feasibility of the approach by assembling a custom near-infrared enhanced receiver APD module including wide amplification electronics providing a high gain bandwidth of > 40 Mhz. This receiver was then used in an adaptive optics SLO (AOSLO) at the University of Alabama, Birmingham. Through its use, images of a living retina were recorded with a tunable laser source from 600 to 1070 nm. This was the first time such images were realized with a signal receiver. During Phase II, we will address the reliability, manufacturing, packaging and commercial concerns of the receiver module. In addition, our research collaborators will continue to use the receiver as it evolves to enable a range of important clinical studies on the living human retina. These studies will include important 3D imaging on of photoreceptor cells, multi-channel sampling, and the acquisition of retinal images with illumination wavelengths longer than presently applied. This information will be used in their studies to better understand the pathogenesis of Pathological Myopia.
PUBLIC HEALTH RELEVANCE: Radiation Monitoring Devices, Inc. proposes to develop a receiver module with response to near-infrared radiation that is significantly higher than any currently available product. This module will promote new retinal imaging technologies and let specialist utilize established diagnostic imaging instruments in a much more effective manner. As part of the proposed effort, the module will be utilized to help predict the onset of pathological myopia, a common retinal disease affecting millions of people worldwide.
描述(由申请人提供):诊断和理解致盲性视网膜疾病的一些最有用的工具依赖于光谱反射率的使用。这些工具的改进,特别是在过去十年中,极大地提高了我们获得人类视网膜极高分辨率图像的能力。特别是,扫描激光检眼镜通过对视锥细胞马赛克进行成像,同时向单个视锥细胞提供刺激,已被证明是微视野测量、心理物理学和视觉神经科学研究的一项重要技术。由于视网膜成像过程中现在实现了前所未有的分辨率,因此越来越需要使用更长波长的光,这些光可以更深入地渗透到组织中,并且人眼不可见或无法察觉。受人眼响应和增加的光吸收的限制,使用 900 至 1100 nm 之间的波长是最合适的解决方案。不幸的是,虽然有几家供应商提供了在此波长范围内的良好光源,但没有合适的光电探测器。因此,这项研究工作的目标是开发一种雪崩光电二极管 (APD) 模块,该模块在可见光到 1050 nm 范围内具有出色的响应,并且与现有的扫描激光检眼镜兼容。我们提出的解决方案利用 APD 对近红外辐射的高响应度来开发可用于检眼镜和其他健康科学的接收器模块。在第一阶段,我们通过组装定制近红外增强接收器 APD 模块(包括提供 > 40 Mhz 的高增益带宽的宽放大电子器件)成功证明了该方法的可行性。该接收器随后被用于伯明翰阿拉巴马大学的自适应光学 SLO (AOSLO)。通过使用它,用 600 至 1070 nm 的可调谐激光源记录了活体视网膜的图像。这是第一次用信号接收器实现此类图像。在第二阶段,我们将解决接收器模块的可靠性、制造、封装和商业问题。此外,我们的研究合作者将继续使用接收器,随着它的发展,以实现对活体人类视网膜的一系列重要临床研究。这些研究将包括重要的感光细胞 3D 成像、多通道采样以及使用比目前应用的照明波长更长的照明波长采集视网膜图像。这些信息将用于他们的研究,以更好地了解病理性近视的发病机制。
公共健康相关性:辐射监测设备公司提议开发一种接收器模块,其对近红外辐射的响应明显高于任何现有产品。该模块将推广新的视网膜成像技术,并让专家以更有效的方式利用现有的诊断成像仪器。作为拟议工作的一部分,该模块将用于帮助预测病理性近视的发病,这是一种影响全球数百万人的常见视网膜疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Richard Myers其他文献
Richard Myers的其他文献
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{{ truncateString('Richard Myers', 18)}}的其他基金
Cancer Detection Using Diffuse Luminescence Imaging
使用漫射发光成像检测癌症
- 批准号:
7681011 - 财政年份:2004
- 资助金额:
$ 71.78万 - 项目类别:
Cancer Detection Using Diffuse Luminescence Imaging
使用漫射发光成像检测癌症
- 批准号:
7537285 - 财政年份:2004
- 资助金额:
$ 71.78万 - 项目类别:
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