How intra-abdominal transplantation of subcutaneous adipose tissue prevents high-fat diet-induced insulin resistance and obesity

腹腔内皮下脂肪组织移植如何预防高脂饮食引起的胰岛素抵抗和肥胖

• 批准号: nhmrc : 1031769
• 负责人: Dr Amanda Brandon
• 金额: $ 23.9万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/intra-abdominal-transplantation-resistance-obesity/110821
• 关键词: How; intra; abdominal; transplantation; subcutaneous

In obese humans, storing excess fat within the abdomen is associated with the development of adult-onset diabetes and cardiovascular disease. However, the mechanisms linking intra-abdominal fat accumulation with these diseases are not well understood. We have studied intra-abdominal fat accumulation in mice using a transplant model, and we have found that transplanting subcutaneous fat intra-abdominally prevents diet-induced obesity and glucose intolerance. We aim to investigate the underlying mechanisms.

在肥胖的人中，在腹部储存多余的脂肪与成人发病的糖尿病和心血管疾病的发展有关。然而，腹腔内脂肪积聚与这些疾病的联系机制还不清楚。我们已经使用移植模型研究了小鼠腹腔内脂肪积累，并且我们发现腹腔内移植皮下脂肪可以预防饮食诱导的肥胖和葡萄糖耐受不良。我们的目标是研究潜在的机制。