How intra-abdominal transplantation of subcutaneous adipose tissue prevents high-fat diet-induced insulin resistance and obesity

点击翻译按钮获取中文摘要

In obese humans, storing excess fat within the abdomen is associated with the development of adult-onset diabetes and cardiovascular disease. However, the mechanisms linking intra-abdominal fat accumulation with these diseases are not well understood. We have studied intra-abdominal fat accumulation in mice using a transplant model, and we have found that transplanting subcutaneous fat intra-abdominally prevents diet-induced obesity and glucose intolerance. We aim to investigate the underlying mechanisms.