The Molecular Basis of Local Adaptation in Arabidopsis thaliana

拟南芥局部适应的分子基础

• 批准号: 8286941
• 负责人: JOY M BERGELSON
• 金额: $ 35.54万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8286941
• 关键词: Agriculture; Alleles; Angiosperms; Architecture; Biology; Blood Pressure; Brassicaceae; California; Chromosome Mapping; Collaborations; Complement; Computer Simulation; Cues; Droughts; Ecology; Ensure; Environment; Evolution; Flowers; Genes; Genetic; Genetic Polymorphism; Genetic Variation; Genome; Genomics; Genotype; Goals; Health; Human; Inbreeding; Individual; Linkage Disequilibrium; Linkage Disequilibrium Mapping; Maps; Measures; Methods; Modeling; Molecular; Molecular Genetics; Mouse-ear Cress; Pattern; Phenotype; Plant Model; Plants; Population; Quantitative Trait Loci; Recording of previous events; Regulation; Resolution; Resources; Rice; Sampling; Seasons; Single Nucleotide Polymorphism; Structure; Surveys; Techniques; Temperature; Time; Translating; Tweens; Universities; Variant; authority; base; cold temperature; design; fitness; genetic linkage analysis; genome wide association study; genotyping technology; interest; research study; response; trait

Project Summary One of the most important challenges facing biology today is making sense of genetic variation. Un- derstanding how genotypic variation translates into phenotypic variation and how it is structured in populations is fundamental to our understanding of evolution, and has enormous practical implications for human health as well as for agriculture and conservation. The long-term objective of this project is to increase our understanding of the molecular genetic basis for adaptive variation by studying flower- ing time in A. thaliana. The focus is on the flowering response to cold temperatures, so-called vernal- ization, which is one of the major mechanisms plants use to ensure that they flower at the right time, during the right season. The project seeks to describe the genetic architecture underlying variation for this trait, and will identify, at the molecular level, the major genes and alleles involved. The adaptive significance of the identified polymorphisms will be determined in field trials. The project has three spe- cific aims: First, to map the genes responsible for variation between plants collected in different parts of the world. The mapping will be done using a combination of traditional linkage mapping methods and so-called genome-wide association scans, in which modern genotyping technology is used to survey massive amounts polymorphisms in population samples in order to identify genomic regions that appear to be statistically associated with the trait. Second, molecular genetics will be used to characterize the identified alleles and loci. Third, the pattern of variation in and around identified loci will be analyzed in order to elucidate the history of selection on the loci. Project Narrative One of the most important challenges facing biology today is understanding how genetic variation be- tween individuals translates into variation we can see or measure, like blood pressure in humans, or drought tolerance in rice. The goal of this project is to increase our understand of the general principles that underlie the genetics of adaptive natural variation by studying flowering time in the model plant thale cress (Arabidopsis thaliana). The focus is on the flowering response to cold temperatures, so-called vernalization, which is one of the major mechanisms plants use to ensure that they flower at the right time, during the right season.

项目摘要 当今生物学面临的最重要的挑战之一是理解遗传变异。Un- 了解基因型变异如何转化为表型变异，以及它是如何在 种群是我们理解进化的基础，具有巨大的实际意义。 对人类健康以及农业和自然保护都有好处。该项目的长期目标是 通过研究花，增加我们对适应性变异的分子遗传基础的理解， 时间在A。thaliana.重点是开花对寒冷温度的反应，所谓的春季- 化，这是植物用来确保它们在正确的时间开花的主要机制之一， 在合适的季节。该项目旨在描述变异的遗传结构， 这一特性，并将确定，在分子水平上，主要基因和等位基因参与。自适应 将在田间试验中确定鉴定的多态性的意义。该项目有三个特殊- 具体目标：首先，绘制不同部位收集的植物之间变异的基因图谱 of the world.将使用传统的连锁作图方法的组合进行作图 和所谓的全基因组关联扫描，其中现代基因分型技术用于调查 在人群样本中发现大量的多态性， 在统计学上与该特征相关。第二，分子遗传学将用于表征 确定等位基因和基因座。第三，将分析所鉴定的基因座内和周围的变异模式 以阐明基因座选择的历史。项目叙述 当今生物学面临的最重要的挑战之一是了解遗传变异是如何- 个体之间的差异转化为我们可以看到或测量的变化，比如人类的血压， 水稻的耐旱性这个项目的目标是增加我们对一般原则的理解 通过研究模式植物的开花时间， 塔勒水芹（拟南芥）。重点是开花对低温的反应，所谓的 春化作用，这是植物用来确保它们在正确的时间开花的主要机制之一。 时间，在合适的季节。

项目成果

An atypical kinase under balancing selection confers broad-spectrum disease resistance in Arabidopsis.

• DOI: 10.1371/journal.pgen.1003766
• 发表时间: 2013
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Huard-Chauveau C;Perchepied L;Debieu M;Rivas S;Kroj T;Kars I;Bergelson J;Roux F;Roby D
• 通讯作者: Roby D

Differentiation between MAMP Triggered Defenses in Arabidopsis thaliana.

• DOI: 10.1371/journal.pgen.1006068
• 发表时间: 2016-06
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Vetter M;Karasov TL;Bergelson J
• 通讯作者: Bergelson J

Natural Bacterial Assemblages in Arabidopsis thaliana Tissues Become More Distinguishable and Diverse during Host Development.

• DOI: 10.1128/mbio.02723-20
• 发表时间: 2021-01-19
• 期刊: mBio
• 影响因子: 6.4
• 作者: Beilsmith K;Perisin M;Bergelson J
• 通讯作者: Bergelson J

Genome-wide association mapping within a local Arabidopsis thaliana population more fully reveals the genetic architecture for defensive metabolite diversity.

• DOI: 10.1098/rstb.2020.0512
• 发表时间: 2022-07-18
• 期刊: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
• 影响因子: 6.3
• 作者: Gloss, Andrew D.;Vergnol, Amelie;Morton, Timothy C.;Laurin, Peter J.;Roux, Fabrice;Bergelson, Joy
• 通讯作者: Bergelson, Joy

Modulation of R-gene expression across environments.

• DOI: 10.1093/jxb/erv530
• 发表时间: 2016-03
• 期刊: Journal of experimental botany
• 影响因子: 6.9
• 作者: MacQueen A;Bergelson J
• 通讯作者: Bergelson J