细胞周期遗传学-猫眼课题宝

细胞周期遗传学

批准号：

8319419

负责人：

STEPHEN J ELLEDGE

金额：

$34.3万

依托单位：

BRIGHAM AND WOMEN'S HOSPITAL

依托单位国家：

美国

项目类别：

财政年份：

1990

资助国家：

美国

项目状态：

已结题

起止时间：

1990-07-01 至 2013-06-30

来源：

https://reporter.nih.gov/project-details/8319419

关键词：

Affinity Affinity Chromatography Alleles Am 80 Amino Acids Anaphase Antibodies Binding Biochemical C-terminal CHEK2 gene Cations Cell Cycle Cell Cycle Arrest Cell Cycle Regulation Cells Characteristics Charge Chromatin Chromosome Segregation Chromosomes Complex Consensus Cyclic AMP-Dependent Protein Kinases Cyclin-Dependent Kinases DNA Damage DNA Double Strand Break DNA Repair DNA Replication Damage DNA biosynthesis DNA damage checkpoint Databases Daughter Defect Ensure Essential Genes Eukaryota Event Failure Future Genetic Genetic Epistasis Genetic Screening Goals Grant Homologous Gene In Vitro Investigation Ionizing radiation Iron Kinetochores Lead Left Light Cell Link MCM Protein Mammals Mass Spectrum Analysis Methods Microtubules Mitosis Mitotic Mitotic spindle Modeling Mutagenesis Mutagens Mutate Mutation N-terminal Nocodazole Nuclear Nuclear Protein PDE2 phosphodiesterase Paint Paper Pathway interactions Peptide Fragments Peptides Phenotype Phosphopeptides Phosphorylation Phosphorylation Site Phosphotransferases Play Process Protein Binding Protein Kinase Proteins Proteomics RNA Splicing Reagent Recruitment Activity Regulation Relative (related person)Resistance Role S Phase Saccharomyces cerevisiae Series Serine Set protein Signal Transduction Signal Transduction Pathway Sister Chromatid Site Stable Isotope Labeling Stress Structure Temperature Tern Trypsin Work Yeasts arginyllysine base cell cycle genetics crosslink daughter cell dosage graduate student helicase hydroxyurea in vivo inorganic phosphate interest men mutant novel prevent protein function ras-Related G-Proteins repaired research study response sensor spindle pole body yeast protein

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中文摘要

翻译

我们的实验室一直专注于细胞如何感知和应对DNA损伤。我们一直非常活跃 N阐明了DNA损伤反应传感器所感知的结构。通过在酵母和哺乳动物我们已经建立了信号转导通路的轮廓，该通路被激活以响应 DNA损伤。这一途径由蛋白激酶级联组成。我们一直很感兴趣了解DNA损伤反应如何控制细胞周期调控的各个方面，并因此对细胞周期也进行了研究。为了了解DNA损伤反应是如何为了实现它的目标，我们必须确定激活的激酶的底物 DNA损伤并阐明这些底物的功能。

英文摘要

Our lab has been focused on how cells sense and respond to DNA damage. We have been very active n elucidating the structures sensed by the DNA damage response sensors. Through work in both yeast and mammals we have established an outline of the signal transduction pathway that is activated in response to DNA damage. This pathway consists of a protein kinase cascade. We have been very interested in understanding how the DNA damage response controls various aspects of cell cycle regulation and have therefore studied the cell cycle as well. In order to understand how the DNA damage response accomplishes its goals, it is imperative we identify the substrates of the kinases activated in response to DNA damage and elucidate the function of these substrates.

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