Interdepartmental Training in Pharmacological Sciences

描述(由申请人提供)：密歇根大学药理学和生物相关化学培训计划(PSTP)为博士生预科学生提供基本药理学原理的坚实基础和其他与生物相关的基础科学学科(如药物化学)的广泛知识。所有学生将完成一门核心课程，包括药理学、药物化学、生理学和生物统计学课程，以及其他为满足个别学生的课程需求而设计的选修课。学生可以遵循两条一般路线中的一条，重点是生物或化学研究。该计划的研究重点领域包括心血管/肾脏药理学、神经药理学、异物代谢、生长和代谢调节、受体结构和功能、治疗和诊断药物的合成和药理学、抗生素发现、酶学、转运机制、药物吸收、药物输送和药物动力学。学生在几种类型的药理学研究中获得实验室经验，并学习如何设计实验，评估实验数据，并使用适当的统计方法。培训计划包括研究生水平的课程；负责任的研究行为培训；研讨会计划；资格考试；职业和职业发展活动(本申请的新内容)；在年度研讨会上要求的研究报告；指导下的实验室调查，以帮助学生完成博士论文；以及期末口试，在此期间，受训者在论文委员会面前为自己的论文辩护。高素质的学生有兴趣获得在他们的博士课程中通常无法获得的药理科学方面的高级培训，他们的博士课程将提名他们进入PSTP。他们的教师导师必须是PSTP的成员。从2010-11学年开始，所有被提名参加PSTP的学生都将接受预选委员会的审查，该委员会将根据学生的研究和具体培训兴趣将他们分配到生物或化学课程。然后，被提名者将由两个具体轨道小组委员会进行评估，这些小组委员会随后建议任命PSTP家长委员会成员，后者做出最终决定。遴选标准包括：UG和研究生GPA，GRE，研究经验，推荐信，研究生院研究轮换中的表现，以及个人面试。学生在研究生院二年级开始时进入PSTP，通常由为期两年的培训补助金(第一阶段)提供经济支持。学员的博士课程和PSTP都严格执行招生、课程评分、资格考试、实验室经验和论文工作的政策，以保持高水平的质量。在第二阶段(在候选人资格和PSTP支持之后)，受训者的进度由他们的导师和额外的PSTP教职员工通过必要的年度论文委员会会议监督，并向PSTP主任提交必要的书面报告。要求每年为16名受训人员提供支助。 公共卫生相关性：药理学培训计划旨在为有兴趣从事与药理学研究相关的生命科学研究事业的学生提供高级培训。重点是基本的药理学原理和获得相关基础科学的广泛知识，如药物化学。向这些未来的研究人员提供的培训将使他们能够致力于与药物治疗相关的医学和人类健康方面的进展。

DESCRIPTION (provided by applicant): The University of Michigan, Pharmacological Sciences and Bio-related Chemistry Training Program (PSTP) provides pre-doctoral students with a strong foundation in basic pharmacological principles and a broad knowledge of other bio-related basic science disciplines (e.g., medicinal chemistry). All students will complete a core curriculum consisting of courses in pharmacology, medicinal chemistry, physiology, and biostatistics, with other elective courses designed to fit the programmatic needs of individual students. Students may follow one of two general tracks with emphasis on biological or chemical research. Areas of research concentration within the program include cardiovascular/renal pharmacology, neuropharmacology, xenobiotic metabolism, growth and metabolic regulation, receptor structure and function, synthesis and pharmacology of therapeutic and diagnostic agents, antibiotic discovery, enzymology, transport mechanisms, drug absorption, drug delivery, and pharmacokinetics. Students obtain laboratory experience in several types of pharmacological research and learn how to design experiments, evaluate experimental data, and use appropriate statistical methods. The training program includes graduate-level courses; training in the responsible conduct of research; seminar programs; a qualifying examination; career and professional development activities (new to this submission); required research presentations at an Annual Symposium; supervised laboratory investigation leading to the student's doctoral dissertation and a final oral examination during which the trainee defends his/her dissertation before their dissertation committee. Highly-qualified students, with an interest in obtaining advanced training in the pharmacological sciences that would not normally be available to them in their PhD programs, are nominated by their PhD program to the PSTP. Their faculty mentors must be members of the PSTP. Starting with the 2010-11 cohort, all students nominated to the PSTP will be reviewed by a pre-selection committee, which will assign the students to either the Biological or Chemical Track based on their research and specific training interests. Nominees will then be evaluated by the two track-specific sub-committees, which then recommend appointment to the PSTP Parent Committee which makes the final decisions. Selection criteria include: UG and graduate GPAs, GREs, research experience, letters of recommendation, performance in research rotations in graduate school, and personal interviews. Students enter the PSTP at the beginning of their second year of graduate school and generally are financially supported by the training grant for two years (Phase I). Rigorous policies of admissions, course grades, qualifying exams, laboratory experiences, and thesis work are enforced by both the trainees' PhD programs and the PSTP to maintain a high level of quality. In Phase II (after candidacy and PSTP support), the trainee's progress is monitored by their mentor and by additional PSTP faculty via a requisite annual dissertation committee meeting, with requisite written reports to the PSTP Directors. Support is requested for 16 trainees per year. PUBLIC HEALTH RELEVANCE: The Pharmacological Sciences Training Program is designed to provide advanced training to students interested in pursuing research careers in the life sciences related to pharmacological research. An emphasis is placed on basic pharmacological principles and acquiring broad knowledge of related basic sciences like medicinal chemistry. The training provided to these future researchers will enable them to work on advances in medicine and human health related to drug therapy.