Interdepartmental Training in Pharmacological Sciences

描述（由申请人提供）：密歇根大学药理学和生物相关化学培训计划（PSTP）为博士预科学生提供基本药理学原理的坚实基础和其他生物相关基础科学学科（如药物化学）的广泛知识。所有学生都将完成一门核心课程，包括药理学、药物化学、生理学和生物统计学课程，以及其他选修课程，以适应个别学生的课程需求。学生可以选择生物或化学研究为主的两大方向之一。该计划的研究领域包括心血管/肾脏药理学，神经药理学，异种代谢，生长和代谢调节，受体结构和功能，治疗和诊断试剂的合成和药理学，抗生素发现，酶学，运输机制，药物吸收，药物传递和药代动力学。学生将获得几种类型药理学研究的实验室经验，并学习如何设计实验、评估实验数据和使用适当的统计方法。培训项目包括研究生水平的课程；培训负责任的研究行为；研讨会项目;资格考试；职业和专业发展活动（本次提交的新内容）；要求在年度研讨会上发表研究报告；指导实验室调查导致学生的博士论文和最后的口头考试期间，受训者捍卫他/她的论文在他们的论文委员会。高素质的学生，有兴趣获得药理学方面的高级培训，这通常是他们在博士课程中无法获得的，由他们的博士课程提名到PSTP。他们的教师导师必须是PSTP的成员。从2010-11学年开始，所有被提名为PSTP的学生将由一个预选委员会进行审查，该委员会将根据学生的研究和特定培训兴趣将学生分配到生物或化学方向。被提名者将由两个特定轨道小组委员会进行评估，然后向PSTP家长委员会提出任命建议，由家长委员会作出最后决定。选择标准包括：大学本科和研究生的gpa、gre、研究经验、推荐信、在研究生院的研究轮转表现和个人面试。学生在研究生院第二年开始时进入PSTP，通常由两年的培训补助金（第一阶段）提供财政支持。严格的招生政策、课程成绩、资格考试、实验室经验和论文工作都由博士生项目和PSTP强制执行，以保持高水平的质量。在第二阶段（在获得候选资格和PSTP支持之后），受训者的进步由他们的导师和PSTP的其他教员通过必要的年度论文委员会会议进行监督，并向PSTP主任提交必要的书面报告。每年请支助16名受训人员。

DESCRIPTION (provided by applicant): The University of Michigan, Pharmacological Sciences and Bio-related Chemistry Training Program (PSTP) provides pre-doctoral students with a strong foundation in basic pharmacological principles and a broad knowledge of other bio-related basic science disciplines (e.g., medicinal chemistry). All students will complete a core curriculum consisting of courses in pharmacology, medicinal chemistry, physiology, and biostatistics, with other elective courses designed to fit the programmatic needs of individual students. Students may follow one of two general tracks with emphasis on biological or chemical research. Areas of research concentration within the program include cardiovascular/renal pharmacology, neuropharmacology, xenobiotic metabolism, growth and metabolic regulation, receptor structure and function, synthesis and pharmacology of therapeutic and diagnostic agents, antibiotic discovery, enzymology, transport mechanisms, drug absorption, drug delivery, and pharmacokinetics. Students obtain laboratory experience in several types of pharmacological research and learn how to design experiments, evaluate experimental data, and use appropriate statistical methods. The training program includes graduate-level courses; training in the responsible conduct of research; seminar programs; a qualifying examination; career and professional development activities (new to this submission); required research presentations at an Annual Symposium; supervised laboratory investigation leading to the student's doctoral dissertation and a final oral examination during which the trainee defends his/her dissertation before their dissertation committee. Highly-qualified students, with an interest in obtaining advanced training in the pharmacological sciences that would not normally be available to them in their PhD programs, are nominated by their PhD program to the PSTP. Their faculty mentors must be members of the PSTP. Starting with the 2010-11 cohort, all students nominated to the PSTP will be reviewed by a pre-selection committee, which will assign the students to either the Biological or Chemical Track based on their research and specific training interests. Nominees will then be evaluated by the two track-specific sub-committees, which then recommend appointment to the PSTP Parent Committee which makes the final decisions. Selection criteria include: UG and graduate GPAs, GREs, research experience, letters of recommendation, performance in research rotations in graduate school, and personal interviews. Students enter the PSTP at the beginning of their second year of graduate school and generally are financially supported by the training grant for two years (Phase I). Rigorous policies of admissions, course grades, qualifying exams, laboratory experiences, and thesis work are enforced by both the trainees' PhD programs and the PSTP to maintain a high level of quality. In Phase II (after candidacy and PSTP support), the trainee's progress is monitored by their mentor and by additional PSTP faculty via a requisite annual dissertation committee meeting, with requisite written reports to the PSTP Directors. Support is requested for 16 trainees per year.