IRS phosphorylation by type I IL-4R signaling and its role in allergic disease

IRS 磷酸化 I 型 IL-4R 信号及其在过敏性疾病中的作用

• 批准号: 8307122
• 负责人: NICOLA M HELLER
• 金额: $ 24.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8307122
• 关键词: 2-tyrosine; Acetylation; Allergic; Allergic Disease; Allergic inflammation; Amino Acid Sequence; Asthma; Award; Biological Assay; Biology; Cells; Characteristics; Chronic; Co-Immunoprecipitations; Complex; Cytokine Inducible SH2-Containing Protein; Cytoplasmic Tail; Data; Disease; Down-Regulation; Environment; Epithelium; Extrinsic asthma; Fibroblasts; Gene Expression; Genes; Goals; Hematopoietic; Human; In Vitro; Individual; Inflammation; Inflammatory; Instruction; Insulin; Insulin-Like Growth Factor I; Interleukin-4; JAK2 gene; JAK3 gene; Janus kinase; Janus kinase 3; Lead; Link; Lung; Lung diseases; Mediating; Molecular; Mus; Ovalbumin; Pathogenesis; Pathway interactions; Patients; Phase; Phosphorylation; Phosphotransferases; Play; Post-Translational Protein Processing; Proteins; Receptor Signaling; Recruitment Activity; Regulation; Research; Research Training; Role; Scientist; Serine; Signal Pathway; Signal Transduction; Signaling Protein; TYK2; Testing; Therapeutic; Translating; Tyrosine Phosphorylation; Up-Regulation; arginase; base; career; career development; cell type; design; inhibitor/antagonist; insulin receptor substrate-2 protein; macrophage; meetings; monocyte; mutant; receptor; receptor downregulation; receptor expression; response; therapeutic target; therapy design