Late Stage Lung Cancer

晚期肺癌

• 批准号: 8340005
• 负责人: ROBERT Alan FIGLIN
• 金额: $ 53.35万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8340005
• 关键词: Accounting; Activities of Daily Living; Advanced Practice Nurse; Age; Anxiety; Body Weight decreased; Cancer Patient; Caregivers; Caring; Cause of Death; Characteristics; Cognition; Comorbidity; Data; Diagnosis; Dietitian; Disease; Distress; Emotional; Enrollment; Ethnic Origin; Family; Family Caregiver; Gender; Geriatric Assessment; Goals; Healthcare; Hospitals; Individual; Instruction; Intervention; Karnofsky Performance Status; Link; Malignant Neoplasms; Malignant neoplasm of lung; Measures; Memory; Mental Depression; Meta-Analysis; Methods; Modeling; Non-Small-Cell Lung Carcinoma; Nutritional status; Outcome; Palliative Care; Patients; Performance; Phase; Population; Psychologist; Public Health; Quality of life; Research; Research Personnel; Sea; Services; Social Work; Social support; Staging; Structure; Subgroup; Supportive care; Symptoms; System; Testing; Time; Treatment Factor; United States; Unresectable; Visit; Work; base; cancer care; cancer palliative treatment; caregiving; cost; design; falls; functional status; group intervention; improved; instrumental activity of daily living; interdisciplinary collaboration; older patient; physical conditioning; primary outcome; programs; prospective; psychoeducational intervention; psychological distress; psychosocial; satisfaction; social; symptom management; treatment as usual

PROJECT SUMMARY (Sea instructions): Project 2: Late Stage Lung Cancer focuses on Stages Illb-IV unresectable lung cancer within a program project with central themes related to palliative care, quality of life (QOL), and symptom management. This project focuses on Late Stage Lung Cancer, a population who have decreased survival and high QOL and symptom concerns. The aims of the research are: Aim1: Test the effects of the Palliative Care Intervention (PCI) on overall QOL and psychological distress for patients with Late (Stage Illb-IV) non-resectable NSCLC compared to a group receiving usual care. Aim 2: Compare symptom control in the PCI group versus the usual care group in Late Stage NSCLC. Aim 3: Compare geriatric assessment outcomes (OARS Instrumental Activities of Daily Living, MOS Activities of Daily Living, MOS Social Activities Limitation Scale, Hospital Anxiety and Depression Scale scores, and the Karnofsky Performance Scale) in the PCI group versus the usual care group. Aim 4: Test the effects of the PCI on resource use as compared to the usual care group. Aim 5: Identify subgroups of patients who benefit most from the PCI in relation to sociodemographic characteristics, treatment factors, and geriatric assessment predictors at the 12 week primary end point. A two-group, prospective sequential, quasi-experimental, tandem enrollment design (N=326) will be used for this project, in which the usual care group is accrued and followed during Phase 1 and the intervention group is accrued and followed during Phase 2. The proposed PCI intervention combines pre-treatment assessment and goal setting through the collaboration of an interdisciplinary team. The Palliative Care Intervention is based on pilot work completed from 2005-2007 by the investigators documenting needs of lung cancer patients and testing the intervention. This project has great significance to public health given the significant numbers of people diagnosed with lung cancer and the associated individual and societal costs.

项目摘要（海上说明）： 项目2：晚期肺癌重点介绍一个计划项目中不可切除的肺癌，该项目的中心主题与姑息治疗，生活质量（QOL）和症状管理有关。该项目的重点是晚期肺癌，肺癌是一种人群，降低了生存率，高质量和症状问题。研究的目的是： AIM1：与接受常规护理的组相比，对患有晚期（阶段IV-IV）不可切除的NSCLC患者的姑息治疗干预（PCI）对整体QOL和心理困扰的影响。 AIM 2：比较PCI组的症状控制与晚期NSCLC的常规护理组。 AIM 3：比较PCI组与通常的护理小组的老年评估结果（日常生活的OARS工具活动，日常生活活动，MOS社交活动限制量表，医院焦虑和抑郁量表得分以及Karnofsky绩效量表）。 AIM 4：与通常的护理组相比，测试PCI对资源使用的影响。 目标5：确定从PCI中受益于社会人口统计学特征，治疗因素和老年评估预测指标的患者的亚组。 该项目将使用两组，前瞻性，准实验性，串联入学设计（n = 326），在该项目中，通常在第1阶段进行了通常的护理组并遵循，并且在第2阶段进行了干预组并遵循。 拟议的PCI干预通过跨学科团队的合作结合了预处理评估和目标设定。姑息治疗干预措施基于2005 - 2007年从2005年至2007年完成的试点工作，记录了肺癌患者需求并测试干预措施。 鉴于大量被诊断为肺癌以及相关的个人和社会成本的人，该项目对公共卫生具有重要意义。