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PHASE I TRIAL TO DETERMINE THE SAFETY AND BIOLOGIC ACTIVITY OF RHU GM-CSF

PHASE I TRIAL TO DETERMINE THE SAFETY AND BIOLOGIC ACTIVITY OF RHU GM-CSF
确定 RHU GM-CSF 安全性和生物活性的 I 期试验
批准号：
6279640
负责人：
ROBERT Alan FIGLIN
金额：
$1.77万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6279640
关键词：
antigen presenting cell clinical research clinical trial phase I colony stimulating factor cytotoxic T lymphocyte drug screening /evaluation human subject human therapy evaluation immune system neoplasm /cancer immunotherapy neoplastic cell tumor antigens

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英文摘要
The human immune system, when appropriately stimulated, has the capacity to recognize and destroy cancer cells. While many pathways of tumor killing have been identified, the most potent is that mediated by tumor- specific cytotoxic T-lymphocytes (CTL,1). The generation of these CTL requires a number of essential components including the presence of tumor antigens, specialized antigen present in cells (APC) and tumor- reactive T cells (2).
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