Cancer Center Support Grant

描述（由申请人提供）：此更新申请要求为希望之城综合癌症中心的NCI癌症中心支持赠款的第25至29年提供资金。该中心现在有五个研究项目：一个基础研究项目（癌症生物学，CB）;三个临床/转化研究项目（发育癌症治疗学，DCT;癌症免疫治疗学，Cl;血液肿瘤，HM）;和一个人口研究项目（癌症控制和人口科学，CCPS）。12个共享资源支持成员的科学活动，包括两个新的核心（小动物成像;临床免疫生物学相关研究实验室）。提出了三个发展核心（高产量筛选;合成和生物聚合物化学;调查研究）。在前一个计划期间，会员人数增长了45%，招募了37名新的正式会员，包括几位关键的高级领导人（理查德·朱弗博士，副主任; R。Figlin，MD，临床研究副总监[AD]）。其他关键领导职位也通过内部任命填补（Smita Bhatia，医学博士，公共卫生硕士，人口研究AD; Joyce Niland，博士，信息科学AD;和Yun Yen，医学博士，博士，翻译研究AD）。由于我们的计划重组，招聘和基础设施的发展，我们现在相信我们有一个中心，我们的五个计划代表了一个连续体，其中基础科学计划，CB和一个临床计划，DCT的基础和转化研究可以与所有三个临床计划的I期和II期临床方案相联系（DCT，CI，HM）和人口科学计划（CCPS）中生存率和症状管理的随访研究。所有这些活动都是由一个中心和机构基础设施，支持生物学的基础和转化研究，现在，小分子方法以非常协作的方式治疗癌症。这种相互作用导致了该中心的第一个孢子，在淋巴瘤;最近的W.M.凯克基金会奖;和八个大型，多调查员奖的续期。 在下一个资助期间，我们将在这些成就的基础上再接再厉，使City of Hope综合癌症中心在其发展中迈出下一步：将更多的实验室发现转化为创新的临床试验，并开发基于疾病的研究项目。中心的82个正式会员和90个准会员已经发表了1001篇文章，书籍章节等，我就没见过他了其中，28%是方案内出版物，22%是方案间出版物。

DESCRIPTION (provided by applicant): This renewal application requests funding for the 25th through 29th years of the NCI Cancer Center Support Grant of the City of Hope Comprehensive Cancer Center. The Center now has five research programs: one basic research Program (Cancer Biology, CB); three clinical/translational research Programs (Developmental Cancer Therapeutics, DCT; Cancer Immunotherapeutics, Cl; Hematologic Malignancies, HM); and one population research program (Cancer Control and Population Sciences, CCPS). Twelve shared resources support the scientific activities of the members, including two new cores (Small Animal Imaging; Clinical Immunobiology Correlative Studies Laboratory). Three developing cores are proposed (High Throughput Screening; Synthetic & Biopolymer Chemistry; Survey Research). Membership has grown by 45% in the preceding program period with the recruitment of 37 new Full Members, including several key senior leaders (Richard Jove, PhD, Deputy Director; R. Figlin, MD, Associate Director [AD] for Clinical Research). Other key leadership positions have also been filled through internal appointments (Smita Bhatia, MD, MPH, AD for Population Research; Joyce Niland, PhD, AD for Information Sciences; and Yun Yen, MD, PhD, AD for Translational Research). As a result of our program restructuring, recruitment and infrastructure development, we now believe we have a Center where our five Programs represent a continuum in which basic and translational studies in the basic science Program, CB, and one clinical Program, DCT, can be linked to Phase I and II clinical protocols in all three clinical programs (DCT, Cl, HM) and follow-up studies in survivorship and symptom management in the population sciences program (CCPS). All these activities are made possible by a Center and Institutional infrastructure that supports basic and translational research in biological and, now, small molecule approaches to cancer in an extraordinarily collaborative fashion. Such interaction has resulted in the Center's first SPORE, in lymphoma; a recent W.M. Keck Foundation award; and the renewal of eight large, multi-investigator awards. During the next funding period, we will build on these achievements so that the City of Hope Comprehensive Cancer Center takes the next step in its evolution: translating more laboratory discoveries into innovative clinical trials and developing disease-based research programs. The 82 Full Members and 90 Associate Members of the Center Programs have published 1001 articles, book chapters, etc., since the last competitive grant review. Of these, 28% are intraprogrammatic and 22% are interprogrammatic publications.