Center for Clinical and Translational Science

临床和转化科学中心

• 批准号: 8261143
• 负责人: THEODORE MAZZONE
• 金额: $ 26.14万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-14 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8261143
• 关键词: Academy; Advocate; Area; Chicago; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Collaborations; Communities; Discipline; Educational Curriculum; Elements; Face; Faculty; FarGo; Future; Grant; Healthcare; Home environment; Housing; Illinois; Institution; Investigation; Lead; Leadership; Medical center; Nature; Online Systems; Organized Financing; Pediatrics; Postdoctoral Fellow; Rationalization; Reporting; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Science; Services; Structure; System; Thinking; Translational Research; Universities; Vision; base; experience; flexibility; improved; innovation; interest; member; novel; pre-doctoral; programs

Establishing the University of Illinois at Chicago (UIC) Center for Clinical and Translational Science (CCTS) will fundamentally alter the nature of clinical and translational investigation at UIC and our partners (Advocate Health Care, Jesse Brown VA Medical Center, Ul Peoria, Ul Rockford, Ul Urbana). Harnessing our diversity of background, interests and expertise, the UIC CCTS will effectively catalyze collaborative thinking and innovation. The CCTS will organize, finance, and house the infrastructure, expertise, and resources of value to clinical translational investigators within a single academic home, with leadership that reports to the highest levels of UIC administration. This reorganization crosses administrative boundaries to harness and enhance existing UIC resources. A major element of UlC's vision for its future its operationalized by establishing the UIC CCTS, which will have the following Specific Alms. Specific Aim # 1: Create and develop an academic home for clinical translational research at UIC. This home will provide a flexible and adaptable infrastructure to stimulate collaborative thinking, generative discourse, and collective action to facilitate clinical and translational investigation. The creation of this home will include establishing a robust Pilot Grant Program, a Clinical and Translational Science Academy, a web-based and geographic single-point-of-access for investigators to make use of CCTS expertise and resources, and a CCTS Matchmaking service to identify and catalyze novel collaborations. Specific Aim # 2 contributes to the academic home by establishing the research service infrastructure (the 6 Research Service Cores) to provide clinical research support services required by clinical and translational investigators. Soecific Aim # 3 contributes to creation of the academic home by providing multifaceted educational experiences for pre-and post-doctoral trainees, junior faculty, and established faculty wishing to extend their thinking beyond their current disciplinary boundaries. Establishing the UIC CCTS will optimize collaboration with our key clinical research partners, and allow us to facilitate new and innovative investigation in pediatrics and community-based science. The administrative reorganization represented by the UIC CCTS will lead to rationalization and integration of significant and mature UIC resources for clinical translational research. It will add to these resources to produce something better for clinical translational researchers and trainees at UIC and at key partner institutions.

建立伊利诺伊大学芝加哥分校(UIC)临床和翻译科学中心(CCTS) 从根本上改变UIC和我们的合作伙伴(健康倡导者)的临床和翻译研究的性质 CARE，杰西·布朗退伍军人医疗中心，Ul Peoria，Ul Rockford，Ul Urbana)。利用我们的多样性 UIC CCTS的背景、兴趣和专业知识将有效地促进协作思维和创新。 CCTS将组织、资助和存放对临床有价值的基础设施、专业知识和资源 在一个学术家庭内的翻译调查人员，具有向UIC最高级别报告的领导力 行政管理。这一重组跨越了行政边界，以利用和加强现有的UIC 资源。ULC对其未来愿景的一个主要内容是通过建立UIC CCTS来运作，该CCTS 将有以下特定的施舍。具体目标1：创建和发展临床学术之家 UIC的翻译研究。这个家将提供灵活和适应性强的基础设施来刺激 协作思维、生成性话语和集体行动，以促进临床和翻译 调查。这个中心的创建将包括建立一个强有力的试点资助计划，一个临床和 翻译科学学院，一个基于网络的地理单点访问，供研究人员进行 利用CCTS的专业知识和资源，以及CCTS的撮合服务来识别和催化创新 合作。具体目标#2通过建立研究服务，为学术之家做出贡献 基础设施(6个研究服务核心)，以提供临床和服务所需的临床研究支持服务 翻译调查员。专门的目标#3为学术家园的创建做出了贡献 为博士后和博士后实习生、初级教员和常设教员提供多方面的教育经验 希望将他们的思维扩展到他们目前的学科界限之外。建立UIC CCTS将 优化与我们主要临床研究合作伙伴的协作，使我们能够促进新的和创新的 儿科和社区科学方面的调查。以行政重组为代表的行政重整 UIC CCTS将导致临床上重要和成熟的UIC资源的合理化和整合 翻译研究。它将增加这些资源，以产生更好的临床翻译 UIC和主要伙伴机构的研究人员和受训人员。

项目成果

Targeting Ruminative Thinking in Adolescents at Risk for Depressive Relapse: Rumination-Focused Cognitive Behavior Therapy in a Pilot Randomized Controlled Trial with Resting State fMRI.

• DOI: 10.1371/journal.pone.0163952
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Jacobs RH;Watkins ER;Peters AT;Feldhaus CG;Barba A;Carbray J;Langenecker SA
• 通讯作者: Langenecker SA

Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization.

• DOI: 10.1016/j.febslet.2012.04.009
• 发表时间: 2012-05-21
• 期刊: FEBS letters
• 影响因子: 3.5
• 作者: Zhou Q;Chen T;Ibe JC;Raj JU;Zhou G
• 通讯作者: Zhou G

Subjective and objective sleep quality modulate emotion regulatory brain function in anxiety and depression.

• DOI: 10.1002/da.22622
• 发表时间: 2017-07
• 期刊: Depression and anxiety
• 影响因子: 7.4
• 作者: Klumpp H;Roberts J;Kapella MC;Kennedy AE;Kumar A;Phan KL
• 通讯作者: Phan KL

Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated transcriptional effects.

• DOI: 10.1038/onc.2013.483
• 发表时间: 2014-11-20
• 期刊: Oncogene
• 影响因子: 8

Treatment of Ampicillin-Resistant Enterococcus faecium Urinary Tract Infections.

耐氨苄青霉素屎肠球菌尿路感染的治疗。

• 发表时间: 2015
• 期刊: Federal practitioner : for the health care professionals of the VA, DoD, and PHS
• 作者: Richey,EricaM;Waters,PatrickW;Jovic,Milica;Rakhman,Claudia
• 通讯作者: Rakhman,Claudia