Pre & Post-Doctoral Training in Nephrology & Hypertension

描述(由申请人提供)： 学术肾病学家仍然迫切需要研究肾脏疾病的病因、发病机制和治疗方法。高血压和糖尿病引起的肾脏疾病在全世界继续以惊人的速度增加；然而，进入这一领域进行研究的个人人数仍然不足。此次培训拨款续期的目的是在肾脏疾病、高血压和肾移植领域提供基础、翻译或临床研究方面的卓越培训。将向博士后(2名博士生或医学博士)和博士后(3名博士后或博士后)研究员提供为期2至3年的培训。每个实习生都将进行研究，并参加授课。可供研究的研究领域很多，包括慢性肾脏疾病、高血压、糖尿病肾病、肾小球肾炎、移植、酸碱和电解质转运、临床调查(结果、药物基因组学和研究人员驱动)以及基础科学(分子生物学、细胞信号或遗传学)。受训者每人将有一名肾脏导师、一名非肾脏(基础科学或临床研究人员)导师和一个核心导师小组。对于那些进入临床研究的人，还可以获得公共卫生学院的公共卫生硕士学位或临床调查专业的硕士学位。在完成培训后，所有申请者将向他们的核心导师小组提交他们的研究摘要，进行Renal Grand轮，并准备一份未来资金的拨款申请，由培训教师仔细评估。我们相信，一个有组织、有重点的项目，提供从基础到临床的全方位肾病学研究培训，将为招募有前途的个人进入富有成效的学术生涯提供一个有吸引力的场所。关联性。肥胖、代谢综合征和糖尿病流行的一个主要后果是患有肾脏疾病的患者数量急剧增加。目前有1000多万人患有不同程度的肾功能障碍，其中近80万人患有终末期或接近终末期的肾脏疾病。然而，进入研究职业生涯的学术肾病学家严重短缺。这笔培训补助金将支持一个有重点的计划，在基础、翻译和临床研究方面培训有前途的候选人，帮助他们为肾脏病的学术生涯做准备。

DESCRIPTION (provided by applicant): There remains a critical need for academic nephrologists to investigate the etiologies, pathogenesis, and management of kidney diseases. Kidney disease from hypertension and diabetes continue to increase at an alarming rate throughout the world; yet the number of individuals entering the field to conduct research continues to be inadequate. The objective of this training grant renewal is to provide superb training in basic, translational, or clinical research in the field of kidney diseases, hypertension, and renal transplantation. Training will be provided to both predoctoral (2 PhD or MD-PhD students) and postdoctoral (3 MDs or PhDs) fellows, for 2 to 3 years. Each trainee will conduct research and also attend didactic lectures. A large variety of research areas are available for study, including chronic kidney disease, hypertension, diabetic renal disease, glomerulonephritis, transplantation, acid-base and electrolyte transport, clinical investigation (outcomes, pharmacogenomics, and investigator-driven), as well as in basic sciences (molecular biology, cell signaling, or genetics). Trainees will each have a renal mentor, a nonrenal (basic science or clinical investigator) mentor, and a core mentor group. For those who enter clinical research an MPH in the School of Public Health or MS in Clinical Investigation can also be obtained. By the completion of their training all applicants will submit a summary of their research to their core mentor group, give Renal Grand Rounds, and prepare a grant application for future funding that is carefully evaluated by the training faculty. It is our belief that an organized, well focused program that offers training across the full spectrum of basic to clinical research in nephrology will provide an attractive venue for the recruitment of promising individuals into a productive academic career. Relevance. A major consequence of the epidemic of obesity, metabolic syndrome, and diabetes has been a dramatic increase in the number of patients suffering from kidney disease. Currently there are over 10 million individuals with variable degrees of renal dysfunction, including nearly 800,000 with either end stage or near end stage renal disease. Yet, there is a critical shortage of academic nephrologists entering investigative careers. This training grant will support a focused program for training promising candidates in basic, translational, and clinical research which should help them prepare for an academic career in nephrology.