Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects.
Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects.
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DOI：
10.1016/j.metabol.2011.09.013
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发表时间：
2012-05
影响因子：
9.8
通讯作者：
Johnson, Julie A.
中科院分区：
文献类型：
--
作者：
Le, MyPhuong T.;Frye, Reginald F.;Rivard, Christopher J.;Cheng, Jing;McFann, Kim K.;Segal, Mark S.;Johnson, Richard J.;Johnson, Julie A.
目前还不清楚高果糖玉米糖浆（HFCS）是否会比蔗糖引起更高的系统果糖浓度，因为它含有更多的果糖，并提供了游离果糖的直接来源。同样不清楚的是，接触较高水平的果糖是否会导致果糖引起的不良反应增加。目的是前瞻性地比较HFCS与蔗糖糖软饮料对急性代谢和血流动力学的影响。在一项随机交叉设计研究中，40名男性和女性饮用了24盎司含高果糖玉米糖浆或蔗糖的饮料。在6小时内采集血液和尿液样本。测量血压、心率、果糖和其他各种代谢生物标志物。果糖曲线下面积和最大浓度、剂量标准化葡萄糖曲线下面积和最大浓度、葡萄糖的相对生物利用度、餐后血清尿酸浓度的变化以及收缩压最大水平均高于含蔗糖饮料。与蔗糖相比，高果糖玉米糖浆导致更多的果糖系统暴露和显著不同的急性代谢效应。
It is unclear whether high fructose corn syrup (HFCS), which contains a higher amount of fructose and provides an immediate source of free fructose, induces greater systemic concentrations of fructose as compared to sucrose. It is also unclear whether exposure to higher levels of fructose leads to increased fructose-induced adverse effects. The objective was to prospectively compare the effects of HFCS- versus sucrose-sweetened soft drinks on acute metabolic and hemodynamic effects. Forty men and women consumed 24 oz of HFCS- or sucrose-sweetened beverages in a randomized crossover design study. Blood and urine samples were collected over 6 hr. Blood pressure, heart rate, fructose, and a variety of other metabolic biomarkers were measured. Fructose area under the curve and maximum concentration, dose normalized glucose area under the curve and maximum concentration, relative bioavailability of glucose, changes in postprandial concentrations of serum uric acid, and systolic blood pressure maximum levels were higher when HFCS-sweetened beverages were consumed as compared to sucrose-sweetened beverages. Compared to sucrose, HFCS leads to greater fructose systemic exposure and significantly different acute metabolic effects.
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影响因子：
7.7
作者：
Kellett, GL;Brot-Laroche, E
通讯作者：
Brot-Laroche, E
DOI：
10.1016/j.bbrc.2006.12.065
发表时间：
2007-02-16
影响因子：
3.1
作者：
Gu, Ning;Adachi, Tetsuya;Tsuda, Kinsuke
通讯作者：
Tsuda, Kinsuke
影响因子：
8.3
作者：
Fields, LE;Burt, VL;Sorlie, P
通讯作者：
Sorlie, P
DOI：
10.1152/ajpregu.00680.2007
发表时间：
2008-03-01
影响因子：
2.8
作者：
Brown, Clive M.;Dulloo, Abdul G.;Montani, Jean-Pierre
通讯作者：
Montani, Jean-Pierre
影响因子：
13.6
作者：
Forman, John P.;Choi, Hyon;Curhan, Gary C.
通讯作者：
Curhan, Gary C.