NEW CHEMICAL TOOLS FOR THE QUANTITATIVE ASSESSMENT OF BIOLOGICAL METABOLOMES
用于生物代谢组定量评估的新化学工具
基本信息
- 批准号:8360433
- 负责人:
- 金额:$ 6.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-06-01 至 2012-05-31
- 项目状态:已结题
- 来源:
- 关键词:BiologicalBiological ProcessChemicalsDiseaseEquilibriumFundingGene ExpressionGeneticGrantLabelMeasurementMetabolicNational Center for Research ResourcesPlayPrincipal InvestigatorReagentResearchResearch InfrastructureResourcesSamplingSourceSpectrum AnalysisSymptomsSystemSystems BiologyTechniquesUnited States National Institutes of HealthVermontbiological systemscomparativecostenzyme activityfunctional groupnoveltechnology developmenttool
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Metabolites play a key role in regulating biological function by activating or inhibiting both gene expression and enzyme activity. Therefore, the quantification of metabolites in a system allows for the comparative analysis of biological samples (systems biology). The development of technologies that allow for the comprehensive quantitative measurement of metabolites will be a crucial first step in restoring metabolic balance and mitigating symptoms of certain diseases.
In order to quantify and compare metabolites, they must be selectively labeled with isotopic markers such that molecules are readily recognized by spectroscopy techniques. Novel chemical reagents are herein proposed that will target the most prevalent metabolite functional groups and allow for the quantification of a large number of the key metabolites of biological systems.
这个子项目是利用资源的许多研究子项目之一。
由NIH/NCRR资助的中心拨款提供。对子项目的主要支持
子项目的首席调查员可能是由其他来源提供的,
包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能
表示该子项目使用的中心基础设施的估计数量,
不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。
代谢产物通过激活或抑制基因表达和酶活性,在调节生物功能中起着关键作用。因此,系统中代谢物的量化允许对生物样本(系统生物学)进行比较分析。能够对代谢物进行全面定量测量的技术的开发将是恢复代谢平衡和减轻某些疾病症状的关键的第一步。
为了量化和比较代谢物,必须选择性地用同位素标记物标记它们,以便分子容易被光谱学技术识别。本文提出的新型化学试剂将针对最普遍的代谢物官能团,并允许对生物系统的大量关键代谢物进行定量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Shane Lamos', 18)}}的其他基金
NEW CHEMICAL TOOLS FOR THE QUANTITATIVE ASSESSMENT OF BIOLOGICAL METABOLOMES
用于生物代谢组定量评估的新化学工具
- 批准号:
8168172 - 财政年份:2010
- 资助金额:
$ 6.79万 - 项目类别:
NEW CHEMICAL TOOLS FOR THE QUANTITATIVE ASSESSMENT OF BIOLOGICAL METABOLOMES
用于生物代谢组定量评估的新化学工具
- 批准号:
7959892 - 财政年份:2009
- 资助金额:
$ 6.79万 - 项目类别:
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