PARTNER FOR BIOMED RES IN ARKANSAS: BIOINFORMATICS CORE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 生物信息学使用强大的计算资源来应用和整合信息技术和生物科学的知识，以识别，制定和解决生物学上复杂的问题。它提供了一个进行计算实验的路径，包括实验设计，执行和数据记录，分析，解释和结果的专业报告。就其本身而言，信息学为个人在生物信息学和相关领域的职业生涯提供了基础。 在阿肯色州BRIN和INBRE提供支持之前，该州的生物信息学工作仅限于阿肯色州大学医学科学（UAMS）、位于小石城的阿肯色州大学（UALR）和国家毒理学研究中心（NCTR; Jefferson，AR）的一些研究项目。随着BRIN/INBRE的资助，生物信息学的环境和兴趣水平发生了巨大变化。阿肯色州INBRE生物信息学核心通过为生物医学研究人员组装和提供生物信息学工具，包括协助建立模型和开发新的信息学基础设施，帮助显著改善了阿肯色州的“生物信息学景观”。 阿肯色州BRIN/INBRE的生物信息学工作集中在两个广泛的领域：建设基础设施和促进合作。这些领域将继续通过促进以下方式来确定阿肯色州INBRE生物信息学核心的使命： + 本科生和研究生水平的生物信息学教育计划 + 为研究人员和教育工作者提供培训和职业发展机会 + 获取生物信息学资源，包括硬件、软件和专业知识 + 的基础设施身体和智力支持生物信息学新计算方法的最新研究 + 研究合作和网络的机会，以确定具有相似和/或互补的兴趣和技能的科学家和临床医生。 生物信息学核心位于UALR Donaghey工程和信息技术学院的信息科学系。阿肯色州INBRE还在托马斯基伯-埃蒙斯博士的指导下支持UAMS的生物信息学。来自两个校区的教师与其他阿肯色州INBRE-supported核心设施合作，为PUI的教师和学生进行的科学研究提供计算支持。在BRIN阶段合作，UALR和UAMS建立了生物信息学研究生课程，提供MS和博士学位。 生物信息学核心的目标和目标 生物信息学核心的目标是 + 改善技术基础设施，支持国际建筑业研究所的各项举措 + 支持研究所发起的生物信息学研究生方案，解决训练有素的生物信息学家和计算生物学家的区域短缺问题 + 扩大阿肯色州INBRE生物信息学核心的全州、区域和国家范围 + 通过在阿肯色州扩大生物信息学的使用来加强生物医学研究。 通过教育和研究计划，我们打算开发下一代基础设施，应用程序和见解，以支持细胞信号传导，生长和分化的INBRE科学主题，并扩大对科学家的培训和支持，开创生物信息学在这些研究领域的应用。为此，将与从事生物信息学教育和研究的学术团体建立战略伙伴关系。通过这些合作伙伴关系，我们将扩大我们的兼容工具，数据和基础设施的基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bioinformatics uses powerful computational resources to apply and integrate knowledge of the elements of information technology and biological sciences to identify, formulate, and solve biologically complex problems. It provides a path for conducting computational experiments, including experimental design, execution and data recording, analysis, interpretation, and professional reporting of results. In itself, informatics provides a foundation for individuals to prepare for a career in bioinformatics and related fields. Prior to the support provided by the Arkansas BRIN and INBRE, the state's bioinformatics efforts were limited to a few research projects at the University of Arkansas for Medical Sciences (UAMS), the University of Arkansas at Little Rock (UALR), and the National Center for Toxicological Research (NCTR; Jefferson, AR). With BRIN/INBRE funding, the environment for and level of interest in bioinformatics changed dramatically. The Arkansas INBRE Bioinformatics Core has helped to significantly improve the "bioinformatics landscape" in Arkansas by assembling and providing bioinformatics tools for biomedical researchers, including assistance with model building, and developing new informatics infrastructure. Bioinformatics efforts for the Arkansas BRIN/INBRE have focused on two broad areas: building infrastructure and fostering collaboration. These areas will continue to define the mission of the Arkansas INBRE Bioinformatics Core by facilitating + Bioinformatics educational programs at both the undergraduate and graduate levels + Training and professional advancement opportunities for research staff and educators + Access to bioinformatics resources, including hardware, software, and expertise + Fundamental infrastructureboth physical and intellectualsupporting state-of-the-art research into new computational methodologies for bioinformatics + Opportunities for research collaboration and networking to identify scientists and clinicians with similar and/or complementary interests and skills. The Bioinformatics Core is housed in the Department of Information Science of the Donaghey College of Engineering and Information Technology at UALR. The Arkansas INBRE also supports bioinformatics at UAMS under the direction of Dr. Thomas Kieber-Emmons. Faculty members from both campuses work with the other Arkansas INBRE-supported core facilities to provide computational support for scientific research performed by faculty and students of PUIs. Working together during the BRIN phase, UALR and UAMS established a graduate program in bioinformatics that offers MS and PhD degrees. GOALS AND OBJECTIVES OF THE BIOINFORMATICS CORE The goals of the Bioinformatics Core are to + Improve the technical infrastructure in support of the INBRE initiatives + Support the INBRE-initiated graduate program in bioinformatics that addresses the regional shortage of trained bioinformaticists and computational biologists + Expand the statewide, regional, and national outreach of the Arkansas INBRE Bioinformatics Core + Enhance biomedical research through expanded use of bioinformatics within Arkansas. Through educational and research initiatives, we intend to develop the next generation of infrastructure, applications, and insights to support the INBRE scientific theme of Cellular Signaling, Growth, and Differentiation and to expand training and support for scientists pioneering the application of bioinformatics in these research areas. This will be done by establishing strategic partnerships with academic groups engaged in bioinformatics education and research. Through these partnerships, we will broaden our base of compatible tools, data, and infrastructure.