Modulation of neuronal excitability

神经元兴奋性的调节

• 批准号: 8556999
• 负责人: JOHN CLAY
• 金额: $ 38.15万
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8556999
• 关键词: Action Potentials; Apnea; Axon; Biological Models; Breathing; Deep Brain Stimulation; Development; Devices; Disease; Electrodes; Fire - disasters; Goals; Human; Implant; Infant; Life; Marketing; Mattresses; Monitor; Noise; Operative Surgical Procedures; Parents; Parkinson Disease; Patients; Physiologic pulse; Preparation; Protocols documentation; Relative (related person); Squid; Tremor; Work; cost; nervous system disorder; neuronal excitability; research study; vibration

During the current fiscal year we have made significant improvements in a mattress in development that monitors apnea in infants and turns on low-level noise-like vibrations in the mattress that produce a switch from apnea to eupnea without waking the infant. Preliminary results in the Parkinson's project have shown that low level electrical noise is sufficient to cause transitions between the non-tremor and the tremor state in patients in the surgical suite immediately after a Deep Brain Stimulation (DBS) electrode has been implanted. Suppression of the tremor was produced using rectangular current pulses administered by a traditional DBS device. Additional experiments will, hopefully, demonstrate noise-induced transitions from the tremor to the non-tremor state without need of the traditional DBS device.

在本财政年度，我们对正在开发的床垫进行了重大改进，该床垫可以监测婴儿的呼吸暂停，并在床垫中开启低水平的噪音样振动，从而在不吵醒婴儿的情况下从呼吸暂停转换为正常呼吸。 帕金森项目的初步结果表明，低水平的电噪声足以在植入脑深部电刺激（DBS）电极后立即引起手术室中患者的非震颤和震颤状态之间的转换。 使用由传统DBS设备管理的矩形电流脉冲来产生震颤的抑制。 另外的实验将有望证明噪声诱导的从震颤到非震颤状态的转变，而不需要传统的DBS设备。