Mood, Substance Use and Suicidality in Bipolar Adolescents: A Prospective Study

双相情感障碍青少年的情绪、药物使用和自杀倾向：一项前瞻性研究

• 批准号: 8332759
• 负责人: TINA R GOLDSTEIN
• 金额: $ 3.79万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8332759
• 关键词: Acute; Adolescent; Affective; Alcohol or Other Drugs use; American; Bipolar Disorder; Cause of Death; Cereals; Clinical; Comorbidity; Data; Differential Diagnosis; Diffuse; Disease; Distal; Evaluation; Exhibits; Feeling suicidal; Foundations; Funding; Grant; Hour; Individual; Interview; Lead; Longitudinal Studies; Maps; Measures; Mental Depression; Mental disorders; Methods; Mood Disorders; Moods; Morbidity - disease rate; Nature; Onset of illness; Parents; Population; Preclinical Drug Evaluation; Prevention; Preventive; Preventive Intervention; Prospective Studies; Public Health; Reporting; Research; Research Personnel; Retrospective Studies; Risk; Risk Factors; Sampling; Sleep; Sleep disturbances; Staging; Substance Use Disorder; Suicide; Suicide attempt; Suicide prevention; Time; Toxicology; Urine; Youth; accomplished suicide; binge drinking; design; disturbance in affect; experience; follow-up; high risk; ideation; improved; mortality; negative mood; prospective; research study; suicidal adolescent; suicidal behavior; suicidal risk; suicide attempter

DESCRIPTION (provided by applicant): Youth suicide constitutes a major public health problem, ranking as the second leading cause of death for youth worldwide. Of all psychiatric disorders in youth, bipolar disorder imparts the greatest risk for suicide, followed by a substance use disorder. Mood disorder and substance use disorders commonly co-occur, and the combination increase the risk for completed suicide in adolescents exponentially over either disorder alone. Unfortunately, effective suicide prevention efforts, particularly for the ultra-high-risk population of youth with mood disorder and substance use, remain limited. This void in the treatment research may be understood by findings that a multitude of factors from a variety of domains contribute to suicidal risk; such factors remain too diffuse and multiply determined to be considered optimal targets for preventive interventions. Experts in the field have thus called for prospective, longitudinal studies in high-risk samples to systematically investigate specific mechanisms of suicide risk in adolescents. The American Association of Suicidology has specifically identified a need for research on proximal, dynamic and modifiable factors for substance use-to inform targeted preventive approaches for high-risk populations.

描述（由申请人提供）：青少年自杀是一个重大的公共卫生问题，是全世界青少年死亡的第二大原因。在所有青少年精神疾病中，双相情感障碍是自杀风险最高的，其次是物质使用障碍。情绪障碍和物质使用障碍通常同时发生，两者的结合大大增加了青少年自杀的风险。不幸的是，有效的自杀预防措施，特别是针对情绪障碍和药物滥用的超高高危人群，仍然有限。治疗研究中的这一空白可以通过以下发现来理解：来自不同领域的众多因素会导致自杀风险；这些因素仍然过于分散，而且数量众多，无法被视为预防性干预措施的最佳目标。因此，该领域的专家呼吁对高风险样本进行前瞻性、纵向研究，以系统地调查青少年自杀风险的具体机制。美国自杀学协会明确指出，有必要对药物使用的近端、动态和可改变因素进行研究，以便为高危人群提供针对性的预防方法。