Neurocognitive, Affective and Psychosocial Correlates of Adolescent Substance Use

青少年药物使用的神经认知、情感和社会心理相关性

• 批准号: 8963300
• 负责人: Natania A Crane
• 金额: $ 4.03万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-16 至 2017-05-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8963300
• 关键词: Address; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Affective; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Area; Brain; Cannabis; Chronic; Cigarette; Clinical; Cognitive; Data; Data Analyses; Data Collection; Dependence; Development; Emotional; Emotions; Employment; Event; Fellowship; Frequencies; Gender; Goals; Growth; Health; High Prevalence; Impairment; Individual; Knowledge; Life; Measures; Mediating; Mental Depression; Mentors; Mentorship; Methodology; Methods; Modeling; National Research Service Awards; Neurobiology; Neurocognitive; Neuropsychology; Nicotine; Outcome; Participant; Pattern; Performance; Process; Psychosocial Factor; Public Health; Recruitment Activity; Research; Research Personnel; Research Project Grants; Rewards; Risk Factors; Sampling; Statistical Methods; Strategic Planning; Structure; Symptoms; Time; Tobacco; Training; Work; adolescent smoking; adolescent substance use; alcohol effect; base; career; clinical practice; cognitive development; experience; falls; functional outcomes; high risk; meetings; mood regulation; negative mood; neurodevelopment; neuropsychological; neurotoxic; parent project; psychologic; psychosocial; psychosocial development; public health relevance; skills; social; trait; underage drinking; young adult

DESCRIPTION (provided by applicant): The goals for the NRSA fellowship are to expand the applicant's knowledge and research experience in substance use, psychosocial correlates of substance use, neuropsychology, and advanced statistical methods. The applicant's career goal is to become an independent researcher examining the neurocognitive and affective sequel of substance use during adolescence. Structured training and mentoring experiences are proposed, as well as a carefully aligned research project to examine how clinical and developmental risk factors contribute to concurrent nicotine, cannabis, and alcohol use during adolescence/young adulthood, and in turn impact neurocognitive and affective functioning and psychosocial outcomes. The training plan includes course work, experience with longitudinal methods and data analyses, regular sponsor meetings, clinical practice, and professional development activities. Substance use often is initiated in adolescence, an important period of neurodevelopment and psychosocial development. Concurrent use of nicotine, alcohol, and cannabis is common among adolescents, and this concurrent use may have a catalytic, potentiating effect, escalating dependence and leading to poorer neurocognitive, affective, and psychosocial outcomes. However, few studies have examined the risk factors for concurrent use, along with the neurocognitive and psychosocial outcomes of concurrent substance use during adolescence/young adulthood. The specific aims of the study are to examine: 1) clinical and developmental risk factors that differentiate 4 concurrent substance use trajectory (none, low, medium, and high) groups (a) at baseline and how these factors (b) vary over time, 2) the neurobiological association of frequency of substance use during adolescence on later affective, reward, and other neurocognitive functions in a stratified sample based upon substance trajectories and gender, and 3) whether substance use trajectories mediate the relationship between baseline differences and subsequent neurocognitive and psychosocial outcomes. This study will leverage a well-characterized, longitudinal sample of adolescents transitioning into adulthood, taking advantage of the extensive longitudinal data on substance use and psychosocial variables and proposing additional measures to address new questions as part of the ongoing data collection. Eighty individuals from the parent project will be equally selected from the trajectories to study neurocognitive and affective functioning and psychosocial outcomes. Mentorship will be provided by experts in the areas of substance use, psychosocial correlates of substance use, neuropsychology, and longitudinal methodology and data analysis. The proposed study will be one of the first to integrate psychosocial and neurocognitive correlates of nicotine, cannabis, and alcohol use during adolescence/young adulthood. In addition to enhancing the applicant's skills, the project also has the potential to greatly advance our understanding of risk factors for and the neurocognitive and psychosocial outcomes of concurrent adolescent substance use, a goal consistent with several facets of NIDA's strategic plan.

描述（由申请人提供）：NRSA奖学金的目标是扩大申请人在物质使用，物质使用的社会心理相关性，神经心理学和先进统计方法方面的知识和研究经验。申请人的职业目标是成为一名独立的研究人员，研究青少年时期物质使用的神经认知和情感后果。提出了结构化的培训和指导经验，以及一个精心调整的研究项目，以研究临床和发育风险因素如何有助于青春期/青年期同时使用尼古丁，大麻和酒精，进而影响神经认知和情感功能以及心理社会结果。培训计划包括课程作业、纵向方法和数据分析经验、定期申办者会议、临床实践和专业发展活动。药物使用通常始于青春期，这是神经发育和心理社会发展的重要时期。同时使用尼古丁、酒精和大麻在青少年中很常见，这种同时使用可能具有催化、增强作用，使依赖性升级，并导致神经认知、情感和心理社会结局较差。然而，很少有研究探讨了同时使用的风险因素，沿着的神经认知和心理社会的结果，同时使用物质在青春期/年轻的成年。这项研究的具体目的是审查：1）区分4种并发物质使用轨迹的临床和发育风险因素（无、低、中和高）组（a）基线时以及这些因素（B）如何随时间变化，2）青春期期间物质使用频率与后来的情感、奖励、和其他神经认知功能的分层样本的基础上的物质轨迹和性别，和3）是否物质使用轨迹介导的基线差异和随后的神经认知和心理社会结果之间的关系。这项研究将利用一个特征良好的，纵向样本的青少年过渡到成年，利用广泛的纵向数据的物质使用和心理变量，并提出额外的措施，以解决新的问题，作为正在进行的数据收集的一部分。将从母项目中平等地选择80名个体来研究神经认知和情感功能以及心理社会结果。指导将由药物使用、药物使用的社会心理相关因素、神经心理学以及纵向方法和数据分析等领域的专家提供。这项拟议的研究将是第一个整合青少年/青年时期尼古丁，大麻和酒精使用的心理社会和神经认知相关性的研究之一。除了增强申请人的技能，该项目也有潜力大大推进 我们对青少年同时使用药物的风险因素和神经认知和心理社会后果的理解，这一目标与NIDA战略计划的几个方面一致。