UK Spinal Cord & Brain Injury Research Center Core Grant

此应用程序是对NINDS计划公告请求机构中心核心的回应 用于支持神经科学研究的拨款。因此，当前的申请寻求创建英国脊柱 脊髓和脑损伤研究中心(SCoBIRC)核心拨款加速10项研究项目 NINDS资助的调查人员目前正在对12架NINDS R01进行PIS，并加强。应用程序 请求支持五个核心设施：行政和生物信息学核心、动物外科和 TBI/SCI模型核心、行为测试核心、显微、图像分析和体视学核心以及 药代动力学与生物标志物核心。尽管一些提议的技术目前已在 个别调查人员的实验室，目前没有一个核心存在。该提案是针对这些的 将资源集中起来，在某些情况下升级和增加额外的设备。专属的 需要为每个核心提供技术支持，以确保它们将以最少的成本高效运行 停机和设备故障，并有助于提高SCoBIRC和其他NINDS支持的生产率 调查人员。预计这些核心还将促进数据通信并促进 全面协作。所有参与的调查人员都记录了使用大多数 核心设施：10个核心中有6个将使用全部5个核心，3个将使用4个核心，只有1个将使用其中的3个。使用 核心将与其他不合格的神经学研究人员共享。PI已经有了相当大的 行政经验，每一位核心董事完全有资格指导使用拟议的 技术。他们将在5个案例中的4个案例中由同样经验丰富的助理主任和 专职的技术人员，将执行试验研究，培训新的调查人员，处理日程安排，维护 用品和设备维护。岩芯的性能将通过指导每季度进行审查 由所有有资格的调查人员组成的委员会。预计这些核心的存在 将极大地促进SCoBIRC任务的完成，该任务旨在发现和 脊髓和脑损伤治疗方法的临床翻译。此外，这些设施将 提供有利于英国神经学研究的集中化技术，并改进 有经验的和年轻的调查人员竞争外部资金的能力。

This application is in response to the NINDS Program Announcement requesting institutional center core grants to support neuroscience research. Accordingly, the current application seeks to create the UK Spinal Cord & Brain Injury Research Center (SCoBIRC) Core Grant to accelerate the research projects of 10 NINDS-funded investigators who are currently Pis on 12 NINDS R01s, and to enhance . The application asks for support for five core facilities: an Administrative and Bioinformatics Core, an Animal Surgery & TBI/SCI Model Core, a Behavioral Testing Core, a Microscopy, Image Analysis & Stereology Core and a Pharmacokinetics and Biomarker Core. Although some of the proposed technologies are currently in place in the laboratories of individual investigators, none of the cores currently exists. The proposal is for these resources to be centralized, in some cases upgraded and added to with additional equipment. Dedicated technical support is requested for each of the cores to insure that they will be run efficiently with minimal downtime and equipment failure, and serve to enhance the productivity of SCoBIRC and other NINDSsupported investigators. It is also expected that these cores will promote communication of data and foster overall collaboration. All of the participating investigators have documented needs for the use of most of the core facilities: 6 of 10 will use all 5 cores, 3 will use 4 of the cores and only 1 will use 3 of them. Use of the cores will be shared with other non-qualifying neurological investigators. The PI has had considerable administrative experience, and each of the Core Directors is fully qualified to direct the use of the proposed technologies. They will be backed up in 4 of the 5 cases with equally experienced Assistant Directors and dedicated technical staff who will perform pilot studies, train new investigators, handle scheduling, maintain supplies and equipment maintenance. The performance of the cores will be reviewed quarterly by a Steering Committee consisting of all of the qualifying investigators. It is anticipated that the existence of these cores will greatly enhance the accomplishment of the SCoBIRC mission which is directed at the discovery and clinical translation of therapeutic approaches for spinal cord and brain injury. In addition, these facilities will make available centralized technologies which will benefit UK neurological research in general, and improve the ability of both experienced and young investigators to compete for extramural funding.