UK Spinal Cord & Brain Injury Research Center Core Grant

此应用程序是响应NINDS计划公告要求机构中心核心 支持神经科学研究。因此，本申请寻求创建英国脊柱外科协会。 Cord & Brain Injury Research Center（SCoBIRC）核心补助金，以加速10个研究项目 NINDS资助的调查人员目前是12个NINDS R 01的PIS，并加强。应用 要求支持五个核心设施：行政和生物信息学核心，动物外科和 TBI/SCI模型核心，行为测试核心，显微镜，图像分析和体视学核心和 药代动力学和生物标志物核心。虽然一些拟议的技术目前已经到位， 在个别研究人员的实验室中，目前没有一个核心存在。该提案针对这些 资源将集中起来，在某些情况下升级和增加额外的设备。专用 每个核心都需要技术支持，以确保它们在最小的 停机时间和设备故障，并有助于提高SCoBIRC和其他NINDS支持的生产力 investigators.预计这些核心还将促进数据交流， 整体合作。所有参与的研究者都记录了使用大部分 核心设施：10个中的6个将使用所有5个核心，3个将使用4个核心，只有1个将使用3个核心。使用 核心将与其他不合格的神经学研究者共享。私家侦探有相当多的 行政经验，每个核心董事都完全有资格直接使用拟议的 技术.他们将在5起案件中的4起案件中得到同样经验丰富的助理主任的支持， 专门的技术人员将进行试点研究，培训新的研究者，处理调度，维护 用品和设备维修。核心的性能将由一个指导小组每季度审查一次。 由所有合格研究者组成的委员会。据预测，这些核心的存在 将大大提高SCoBIRC的使命的完成，这是针对发现和 脊髓和脑损伤治疗方法的临床转化。此外，这些设施将 提供集中的技术，这将有利于英国神经学研究，并提高 有经验的和年轻的研究人员竞争校外资金的能力。

This application is in response to the NINDS Program Announcement requesting institutional center core grants to support neuroscience research. Accordingly, the current application seeks to create the UK Spinal Cord & Brain Injury Research Center (SCoBIRC) Core Grant to accelerate the research projects of 10 NINDS-funded investigators who are currently Pis on 12 NINDS R01s, and to enhance . The application asks for support for five core facilities: an Administrative and Bioinformatics Core, an Animal Surgery & TBI/SCI Model Core, a Behavioral Testing Core, a Microscopy, Image Analysis & Stereology Core and a Pharmacokinetics and Biomarker Core. Although some of the proposed technologies are currently in place in the laboratories of individual investigators, none of the cores currently exists. The proposal is for these resources to be centralized, in some cases upgraded and added to with additional equipment. Dedicated technical support is requested for each of the cores to insure that they will be run efficiently with minimal downtime and equipment failure, and serve to enhance the productivity of SCoBIRC and other NINDSsupported investigators. It is also expected that these cores will promote communication of data and foster overall collaboration. All of the participating investigators have documented needs for the use of most of the core facilities: 6 of 10 will use all 5 cores, 3 will use 4 of the cores and only 1 will use 3 of them. Use of the cores will be shared with other non-qualifying neurological investigators. The PI has had considerable administrative experience, and each of the Core Directors is fully qualified to direct the use of the proposed technologies. They will be backed up in 4 of the 5 cases with equally experienced Assistant Directors and dedicated technical staff who will perform pilot studies, train new investigators, handle scheduling, maintain supplies and equipment maintenance. The performance of the cores will be reviewed quarterly by a Steering Committee consisting of all of the qualifying investigators. It is anticipated that the existence of these cores will greatly enhance the accomplishment of the SCoBIRC mission which is directed at the discovery and clinical translation of therapeutic approaches for spinal cord and brain injury. In addition, these facilities will make available centralized technologies which will benefit UK neurological research in general, and improve the ability of both experienced and young investigators to compete for extramural funding.