Otolith-Dependent Cognition in Mice

小鼠耳石依赖性认知

• 批准号: 8366954
• 负责人: Ryan Matthew Yoder
• 金额: $ 40.34万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-05 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8366954
• 关键词: Alzheimer' s Disease; Animals; Brain; Cells; Cognition; Cognitive; Complement; Critical Pathways; Dementia; Disease; Disorientation; Distal; Drug abuse; Environment; Force of Gravity; Head; Hippocampus (Brain); Impairment; Lesion; Limbic System; Location; Memory; Modeling; Mus; Operative Surgical Procedures; Pathology; Performance; Radial; Relative (related person); Role; Sensory; Signal Transduction; Space Flight; Structure; System; Vestibule; arm; insight; novel strategies; otoconia; prevent; relating to nervous system

DESCRIPTION (provided by applicant): Accurate navigation is thought to depend on a neural representation of directional heading, which is carried by an ascending circuit of head direction cells located throughout the limbic system. This head direction signal appears to depend critically on the vestibular system, as the head direction signal and navigation abilities are disrupted by vestibular damage. However, vestibular lesions also disrupt other brain signals, such as the place cell signal of hippocampus, and navigation deficits may therefore result from this collateral damage. As a complementary approach, the proposed studies will use otoconia-deficient mice, which have degraded head direction signals, to evaluate the role of the head direction signal in landmark navigation and path integration. The proposed studies will provide important insight into the roles of vestibular signals in neural representations of space and the roles of these representations in navigation. A thorough understanding of the vestibular contribution to the neural and cognitive representations of space may allow new approaches to the treatment of vestibular pathologies. PUBLIC HEALTH RELEVANCE: Disorientation can occur in many pathologies, including dementia, Alzheimer's disease, and drug abuse, among others. Understanding the brain mechanisms that contribute to disorientation will advance our ability to treat or prevent this debilitating component of these disorders.

描述（由申请人提供）：准确的导航被认为取决于方向性航向的神经表征，其由位于整个边缘系统中的头部方向细胞的上升回路携带。该头部方向信号似乎关键地取决于前庭系统，因为头部方向信号和导航能力被前庭损伤破坏。然而，前庭损伤也会干扰其他脑信号，如海马的位置细胞信号，因此导航功能障碍可能是由这种附带损伤引起的。作为一种补充方法，拟议的研究将使用耳锥缺陷小鼠，其具有退化的头部方向信号，以评估头部方向信号在地标导航和路径整合中的作用。拟议的研究将提供重要的洞察前庭信号在空间的神经表征的作用和这些表征在导航中的作用。彻底了解前庭对空间的神经和认知表征的贡献，可能会为前庭病变的治疗提供新的方法。 公共卫生相关性：定向障碍可发生在许多病理学中，包括痴呆症、阿尔茨海默病和药物滥用等。了解导致定向障碍的大脑机制将提高我们治疗或预防这些疾病的这种衰弱成分的能力。