Otolith-dependent Brain Functions in Mice

小鼠耳石依赖性脑功能

• 批准号: 9588851
• 负责人: Ryan Matthew Yoder
• 金额: $ 11.07万
• 依托单位: COASTAL CAROLINA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-05 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9588851
• 关键词: Otolith; dependent; Brain; Functions; Mice

 DESCRIPTION (provided by applicant): Accurate navigation is thought to depend on neural representations of location and directional heading, which are carried by head direction cells, place cells, and grid cells. Head direction cells depend more heavily [than place cells] on signals from the otolith organs, but no studies have investigated the otolithic contribution to grid cell activity. Spatial deficits associated with otolith dysfunction may therefore result from disrupted head direction and/or grid cell activity. The proposed studies will test the otolithic contributionto entorhinal cortical grid cell activity during visual and non-visual navigation tasks. Results will provide important insight into the roles of vestibular information in neural representations of space, and the roles of these representations in navigation. A thorough understanding of the vestibular contribution to neural representations of space may enable new treatment approaches for cognitive deficits resulting from vestibular pathology.

 描述（由申请人提供）：准确的导航被认为取决于位置和方向性航向的神经表征，其由头部方向细胞、位置细胞和网格细胞携带。头部方向细胞比位置细胞更依赖于信号 从耳石器官，但没有研究调查的耳石贡献网格细胞的活动。因此，与耳石功能障碍相关的空间缺陷可能是由于头部方向和/或网格细胞活动中断所致。拟议的研究将测试在视觉和非视觉导航任务中耳石对内嗅皮层网格细胞活动的贡献。结果将提供重要的洞察前庭信息在空间的神经表征的作用，以及这些表征在导航中的作用。彻底了解前庭对空间神经表征的贡献，可能会为前庭病理引起的认知缺陷提供新的治疗方法。

项目成果

Otolithic information is required for homing in the mouse.

• DOI: 10.1002/hipo.22410
• 发表时间: 2015-08
• 期刊: HIPPOCAMPUS
• 影响因子: 3.5
• 作者: Yoder, Ryan M.;Goebel, Elizabeth A.;Koeppen, Jenny R.;Blankenship, Philip A.;Blackwell, Ashley A.;Wallace, Douglas G.
• 通讯作者: Wallace, Douglas G.

Otolith dysfunction alters exploratory movement in mice.

• DOI: 10.1016/j.bbr.2017.02.031
• 发表时间: 2017-05-15
• 期刊: Behavioural brain research
• 影响因子: 2.7
• 作者: Blankenship PA;Cherep LA;Donaldson TN;Brockman SN;Trainer AD;Yoder RM;Wallace DG
• 通讯作者: Wallace DG

Otoconia-deficient mice show selective spatial deficits.

• DOI: 10.1002/hipo.22300
• 发表时间: 2014-10
• 期刊: HIPPOCAMPUS
• 影响因子: 3.5
• 作者: Yoder, Ryan M.;Kirby, Seth L.
• 通讯作者: Kirby, Seth L.