The Effects of Hyper and Hypocapnia on Phonatory Laryngeal Resistance
高碳酸血症和低碳酸血症对发声喉阻力的影响
基本信息
- 批准号:8395332
- 负责人:
- 金额:$ 3.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-07-01 至 2013-02-28
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAirway ResistanceBasic ScienceBehaviorBehavioralBlood gasBreathingCarbon DioxideClinicalClinical ResearchCollaborationsCommunicationComplexConflict (Psychology)DataDiagnosisDiseaseDysphoniaDyspneaEnvironmental air flowEquilibriumEvaluationFemaleFutureGasesGoalsHeterogeneityHomeostasisHypercapniaHypocapniaIndividualInvestigationLarynxLiteratureLungMeasuresMethodologyMuscle TensionPathologyPatientsPatternPeer ReviewPhonationPhysiologicalPhysiologyPopulationProductionRegulationRelative (related person)ResearchResistanceRespirationRespiratory physiologyRestRiskRisk FactorsRoleScienceScientistSeriesStagingTreatment ProtocolsVisualVoiceWomanWorkbasedirect applicationexperienceinterdisciplinary approachmeetingsnoveloral communicationpressureprogramsresearch studyrespiratoryvibrationvocal cord
项目摘要
DESCRIPTION (provided by applicant): The larynx has a challenging dual role in the simultaneous regulation of breathing for blood-gas homeostasis and voice production for communication. Particular challenges arise when the larynx is required to alter upper airway resistance to meet respiratory demands in a way that conflicts with requirements for voice production. This challenge is particularly for relevant the estimated 25% of the US population who experience respiratory abnormalities and also use the larynx for oral communication [1-16] Unfortunately, the vast majority of studies in respiratory physiology fail to appreciate the overla of laryngeal function in voice production, just as most studies in phonatory physiology fail to consider the lower airway's responsibility for blood-gas exchange. In fact, the larynx has the unique role of sustaining blood-gas homeostasis via regulation of the flow of gases into and out of the lungs as well as establishing resistance required for vocal fold vibration in voiced communication. Little if anything is known about reciprocal relations between these functions, particularly under conditions of respiratory abnormality that affect large sectors of the population. The primary objective of the current proposal is to address this gap by assessing the effects of varying concentrations of arterial carbon dioxide on laryngeal function during phonation. The secondary objective is to assess the inverse function, and that is the effects of laryngeal adjustments during phonation and rest on arterial carbon dioxide levels. The proposed work utilizes an interdisciplinary approach to address two specific aims in a single within-subjects experiment: (SA1) assess spontaneous fluctuations in phonatory laryngeal resistance during states of (a) induced hypocapnia (low arterial carbon dioxide) and (b) induced hypercapnia (high arterial carbon dioxide), in comparison to a control condition and (SA2) investigate reciprocal effects of laryngeal resistance modulations on respiratory homeostasis. The overarching hypothesis is that under conditions in which respiratory and phonatory demands conflict, respiratory requirements will prevail. Specific hypotheses are: (SA1[a] and [b]): phonatory laryngeal resistance will increase during hypocapnia and decrease during hypercapnia, favoring a return towards respiratory homeostasis; (SA2): amount of phonatory laryngeal resistance will in turn modulate relative homeostatic condition. Data to this effect would provide critical evidence on how respiratory and laryngeal functions may interact in phonation under conditions of respiratory abnormality. Results from this basic science study will provide a platform for future clinical research, which will explore the hypothesis that respiratory
induced changes in laryngeal function may increase the risk of phonatory malfunction, will identify bio-behavioral markers for at-risk individuals, and will develop targeted evaluation and treatment protocols for them.
PUBLIC HEALTH RELEVANCE: The proposed research will measure the effects of hypercapnia and hypocapnia on laryngeal airway resistance during phonation, and in turn the effects of laryngeal airway resistance changes on resulting blood gas levels. Results from the present study will guide future clinical research investigating the potential pathogenic influence of blood gas changes in affected individuals, potentially putting them at risk for laryngeal malfunction and pathology. Future research will also aim to identify bio-behavior markers for individuals at risk for respiratory-induced laryngeal pathology, and to establish targeted evaluation and treatment of at-risk individuals.
描述(由申请人提供):喉在同时调节血气稳态的呼吸和交流的声音产生方面具有挑战性的双重作用。当喉部需要改变上气道阻力以满足呼吸需求时,会出现与发声要求相冲突的特殊挑战。这一挑战尤其与估计25%的美国人口相关,他们经历呼吸异常并且还使用喉部进行口头交流[1-16]。不幸的是,绝大多数呼吸生理学研究未能认识到喉部在发声中的整体功能,正如大多数发声生理学研究未能考虑下气道对血液气体交换的责任一样。事实上,喉具有通过调节气体流入和流出肺部来维持血气稳态的独特作用,以及建立发声通信中声带振动所需的阻力。对于这些功能之间的相互关系,特别是在影响大部分人口的呼吸异常的情况下,知之甚少。目前建议的主要目标是通过评估不同浓度的动脉二氧化碳对发声过程中喉功能的影响来解决这一差距。第二个目的是评估反函数,即发声和休息期间喉部调节对动脉二氧化碳水平的影响。拟议的工作利用跨学科的方法,以解决两个具体目标,在一个单一的学科内实验:(SA 1)评估(a)诱导的低碳酸血症状态期间发声喉阻力的自发波动(低动脉二氧化碳)和(B)诱导的高碳酸血症(高动脉二氧化碳),和(SA 2)研究喉阻力调节对呼吸稳态相互作用。总体假设是,在呼吸和发声需求冲突的条件下,呼吸需求将占上风。具体假设如下:(SA 1 [a]和[B]):发声喉阻力将在低碳酸血症期间增加,并在高碳酸血症期间减少,有利于恢复呼吸稳态;(SA 2):发声喉阻力的量将进而调节相对稳态条件。这一效应的数据将提供关键的证据,呼吸和喉功能如何可能在发声呼吸异常的条件下相互作用。这项基础科学研究的结果将为未来的临床研究提供一个平台,该研究将探索呼吸系统疾病的假设。
喉功能的诱导变化可能会增加发声功能障碍的风险,将确定处于危险中的个体的生物行为标记,并将为他们制定有针对性的评估和治疗方案。
公共卫生相关性:拟议的研究将测量高碳酸血症和低碳酸血症对发声过程中喉气道阻力的影响,进而测量喉气道阻力变化对血气水平的影响。本研究的结果将指导未来的临床研究,调查受影响个体的血气变化的潜在致病影响,可能使他们面临喉功能障碍和病理学的风险。未来的研究还将致力于确定个体的生物行为标志物,为有风险的麻醉诱导喉病理,并建立有针对性的评估和治疗的风险个体。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Effects of Hyper- and Hypocapnia on Phonatory Laryngeal Airway Resistance in Women.
高碳酸血症和低碳酸血症对女性发声喉气道阻力的影响。
- DOI:10.1044/2015_jslhr-s-13-0270
- 发表时间:2015
- 期刊:
- 影响因子:0
- 作者:Gillespie,AmandaI;Slivka,William;AtwoodJr,CharlesW;VerdoliniAbbott,Katherine
- 通讯作者:VerdoliniAbbott,Katherine
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Amanda I Gillespie其他文献
Amanda I Gillespie的其他文献
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