Examining inhibition during spoken word production in aphasia

描述(申请人提供)：失语症，语言能力障碍，可能部分与注意力减退有关。既要注意促进优先级信息的激活，又要积极抑制干扰信息。据报道，对干扰的感知包括两个组成部分--兴奋和抑制。对失语症的研究表明，在干扰存在的情况下，语言过程明显减慢。虽然这些结果是关键的，但组成干扰控制的两个组成部分--抑制和激发--仍有待探索。这项拟议的研究将检验失语症成年人与年龄和教育程度匹配的对照组在口语产生过程中的抑制情况。40名参与者--20名患有失语症的成年人和20名对照组--将被招募参加一项两组、五种条件的实验，该实验使用Stroop颜色词任务，这是一种众所周知的干扰测试，而嵌入的负启动任务则是一种被广泛接受的抑制措施。所有反应的正确言语反应潜伏期和准确性将在参与者组内和参与者之间进行分析，以确定失语症患者与对照组相比的抑制程度。这项研究是旨在探索抑制作用的一系列研究中的第一项， 兴奋，并有助于失语症的工作记忆模型。最终，这一系列研究将为失语症患者的评估和治疗实践提供参考。 与公共健康相关：抑制-或抑制干扰信息-是语言过程的重要组成部分，但对失语症的抑制功能知之甚少。拟议中的研究将检查失语症成年人在口语产生过程中的抑制。这项研究是一系列研究中的第一项，这些研究将有助于建立失语症的工作记忆模型，并最终为失语症康复提供新的方法。

DESCRIPTION (provided by applicant): Aphasia, disorder of language performance, may relate in part to diminished attention. Attention is required to both boost activation of priority information and actively inhibit interfering information. Perception of interference reportedly involves two components - excitation and inhibition. Studies of aphasia have shown language processes in the presence of interference are significantly slowed. While these results are critical, the two components which comprise interference control - inhibition and excitation - have yet to be explored. The proposed study will examine inhibition during spoken word production in adults with aphasia compared with age- and education-matched controls. Forty participants - 20 adults with aphasia and 20 controls - will be recruited to participate in a two-group by five-condition experiment using the Stroop color-word task, a well-known test of interference, with an embedded Negative Priming task, a widely accepted measure of inhibition. Correct verbal response latency and accuracy on all responses will be analyzed both within and between participant groups to determine the magnitude of inhibition in people with aphasia compared to controls. This study is the first in a line of research designed to explore inhibition, excitation, and contribute to a working memory model of aphasia. Ultimately, this line of research will inform to assessment and treatment practices for people with aphasia. PUBLIC HEALTH RELEVANCE: Inhibition - or the suppression of distracting information - is an essential part of language processes, yet very little is known about inhibitory function in aphasia The proposed research will examine inhibition during spoken word production in adults with aphasia. This study is the first in a line of research which will contribute to a working memory model of aphasia and ultimately inform new approaches to aphasia rehabilitation.