Seamless Energy Balance Monitoring Solution for Personal Fitness and Clinical Res

描述（由申请人提供）：Valencell开发了一种移动传感器技术-称为Healthset(R)技术-用于通过无线音频耳塞监测生命体征和身体活动。这种高度小型化的传感器技术可以集成到音频耳机、耳机、助听器和耳饰中，实现对能量消耗的无缝移动监测。Valencell的长期目标是增强Healthset技术，提供无缝移动能量平衡监测解决方案，集成在单个可穿戴、无线、高度小型化的音频耳机中。这种移动解决方案将满足几个迫在眉睫的公共需求：1)临床需要一种用于疾病预防和健康管理的一体化可穿戴能量平衡监测仪；2)学术需要一种便携式自动生理数据收集工具；3)消费者需要一种引人入胜的移动健身评估平台。该II期项目的具体目标是临床验证一个可扩展的无缝能量消耗监测平台。这项工作将涉及实施对Healthset传感器技术的改进，以及优化与能量消耗相关的传感器指标的统计模型。此外，将实施并验证一种集成能量消耗监测（通过Healthset技术）和能量摄入监测（通过第三方web应用程序）的移动解决方案。这个移动解决方案将用户的无线Healthset耳塞和手机与第三方移动网络应用程序（如食物和体重日记）连接起来，合并后的数据将被处理，以提供一个有意义和有用的能量平衡指标。这一移动解决方案将允许第三方应用程序向Healthset平台提供重要的能量摄入数据，包括食物日记和无线秤，以及目前由大学、政府实验室和行业开发的新兴传感器技术。在NIH的第二阶段项目中，Valencell将：1)制造和验证用于移动能量消耗监测的第二阶段Healthset原型，2)优化估算总（TEE）和静息（REE）能量消耗的统计模型，3)实现整合能量消耗和能量摄入的无缝移动解决方案，4)在现场环境中验证移动解决方案。第二阶段项目将展示一个无缝的能量平衡监测平台，适合在第三阶段项目中过渡到大规模商业化。

DESCRIPTION (provided by applicant): Valencell has developed a mobile sensor technology - called Healthset(R) technology - for monitoring vital signs and physical activity via a wireless audio earbud. This highly miniaturized sensor technology can be integrated into audio headsets, headphones, hearing aids, and ear jewelry for seamless mobile monitoring of energy expenditure. Valencell's long-term goal is to augment Healthset technology to provide a seamless mobile energy balance monitoring solution, integrated within a single, wearable, wireless, highly miniaturized, audio earpiece. This mobile solution will satisfy several imminent public needs: 1) the clinical need for an all-in-one wearable energy balance monitor for disease prevention and health management, 2) the academic need for a portable, automated physiological data collection tool, and 3) the consumer demand for an engaging, mobile fitness assessment platform. The specific goal of this Phase II program is to clinically validate a scalable and seamless energy expenditure monitoring platform. This work will involve implementing improvements to Healthset sensor technology as well as optimizing the statistical models relating sensor metrics to energy expenditure. Furthermore, a mobile solution for integrating energy expenditure monitoring (via Healthset technology) with energy intake monitoring (via 3rd party web applications) will be implemented and validated. This mobile solution will connect the user's wireless Healthset earbud and mobile handset with 3rd party mobile web applications (such as food and weight diaries), and the combined data will be processed to provide a meaningful and useful energy balance metric. This mobile solution will allow 3rd party applications to provide important energy intake data to the Healthset platform, including food diaries and wireless scales, as well as emerging sensor technologies currently under development by universities, government labs, and industry. In this NIH Phase II program, Valencell will: 1) fabricate and qualify Phase II Healthset prototypes for mobile energy expenditure monitoring, 2) optimize statistical models for estimating total (TEE) and resting (REE) energy expenditure, 3) implement a seamless mobile solution integrating energy expenditure with energy intake, and 4) validate the mobile solution in a field environment. This Phase II program will demonstrate a seamless energy balance monitoring platform that is suitable for transitioning to large-scale commercialization in a Phase III program. PUBLIC HEALTH RELEVANCE: Modifiable health risk factors such as high stress, poor diet, and a sedentary lifestyle account for 25% of all medical expenses and millions of deaths per year worldwide. Seamless mobile energy balance monitoring can empower individuals to live healthier lives, saving trillions in medical expenses. The technology proposed in this Phase II program will help make healthy lifestyles easier, more effective, and more affordable.