Seamless Energy Balance Monitoring Solution for Personal Fitness and Clinical Res

描述（由申请人提供）：Valencell开发了一种移动的传感器技术-称为Healthset（R）技术-用于通过无线音频耳塞监测生命体征和身体活动。这种高度小型化的传感器技术可以集成到音频耳机、耳机、助听器和耳饰品中，以无缝移动的监测能量消耗。Valencell的长期目标是增强Healthset技术，提供无缝的移动的能量平衡监测解决方案，集成在一个单一的，可穿戴的，无线的，高度小型化的，音频耳机。这种移动的解决方案将满足几个迫在眉睫的公众需求：1）临床上对用于疾病预防和健康管理的一体化可穿戴能量平衡监测仪的需求，2）学术上对便携式自动生理数据收集工具的需求，以及3）消费者对引人入胜的移动的健身评估平台的需求。该第二阶段计划的具体目标是临床验证可扩展和无缝的能量消耗监测平台。这项工作将涉及对Healthset传感器技术的改进，以及优化传感器指标与能源消耗相关的统计模型。此外，还将实施和验证一个移动的解决方案，用于整合能量消耗监测（通过Healthset技术）和能量摄入监测（通过第三方网络应用程序）。该移动的解决方案将用户的无线Healthset耳塞和移动的手持设备与第三方移动的网络应用程序（如食物和体重日记）连接起来，并将处理组合数据，以提供有意义和有用的能量平衡指标。该移动的解决方案将允许第三方应用程序向Healthset平台提供重要的能量摄入数据，包括食物日记和无线秤，以及大学、政府实验室和行业目前正在开发的新兴传感器技术。在NIH第二阶段计划中，Valencell将：1）制造和鉴定用于移动的能量消耗监测的第二阶段Healthset原型，2）优化用于估计总（TEE）和静息（REE）能量消耗的统计模型，3）实施整合能量消耗与能量摄入的无缝移动的解决方案，以及4）在现场环境中验证移动的解决方案。第二阶段计划将展示一个无缝的能量平衡监测平台，该平台适合在第三阶段计划中过渡到大规模商业化。 公共卫生相关性：可改变的健康风险因素，如高压力、不良饮食和久坐不动的生活方式，占全球所有医疗费用的25%，每年有数百万人死亡。无缝的移动的能量平衡监测可以使个人过上更健康的生活，节省数万亿美元的医疗费用。第二阶段计划中提出的技术将有助于使健康的生活方式更容易，更有效，更实惠。

DESCRIPTION (provided by applicant): Valencell has developed a mobile sensor technology - called Healthset(R) technology - for monitoring vital signs and physical activity via a wireless audio earbud. This highly miniaturized sensor technology can be integrated into audio headsets, headphones, hearing aids, and ear jewelry for seamless mobile monitoring of energy expenditure. Valencell's long-term goal is to augment Healthset technology to provide a seamless mobile energy balance monitoring solution, integrated within a single, wearable, wireless, highly miniaturized, audio earpiece. This mobile solution will satisfy several imminent public needs: 1) the clinical need for an all-in-one wearable energy balance monitor for disease prevention and health management, 2) the academic need for a portable, automated physiological data collection tool, and 3) the consumer demand for an engaging, mobile fitness assessment platform. The specific goal of this Phase II program is to clinically validate a scalable and seamless energy expenditure monitoring platform. This work will involve implementing improvements to Healthset sensor technology as well as optimizing the statistical models relating sensor metrics to energy expenditure. Furthermore, a mobile solution for integrating energy expenditure monitoring (via Healthset technology) with energy intake monitoring (via 3rd party web applications) will be implemented and validated. This mobile solution will connect the user's wireless Healthset earbud and mobile handset with 3rd party mobile web applications (such as food and weight diaries), and the combined data will be processed to provide a meaningful and useful energy balance metric. This mobile solution will allow 3rd party applications to provide important energy intake data to the Healthset platform, including food diaries and wireless scales, as well as emerging sensor technologies currently under development by universities, government labs, and industry. In this NIH Phase II program, Valencell will: 1) fabricate and qualify Phase II Healthset prototypes for mobile energy expenditure monitoring, 2) optimize statistical models for estimating total (TEE) and resting (REE) energy expenditure, 3) implement a seamless mobile solution integrating energy expenditure with energy intake, and 4) validate the mobile solution in a field environment. This Phase II program will demonstrate a seamless energy balance monitoring platform that is suitable for transitioning to large-scale commercialization in a Phase III program. PUBLIC HEALTH RELEVANCE: Modifiable health risk factors such as high stress, poor diet, and a sedentary lifestyle account for 25% of all medical expenses and millions of deaths per year worldwide. Seamless mobile energy balance monitoring can empower individuals to live healthier lives, saving trillions in medical expenses. The technology proposed in this Phase II program will help make healthy lifestyles easier, more effective, and more affordable.