2012 Craniofacial Morphogenesis & Tissue Regeneration GRS & GRC

描述（由申请人提供）：颅面畸形是常见的出生缺陷，约占所有先天性畸形的三分之一。它们也是婴儿死亡的一个主要原因。总的来说，它们对全国的医疗保健费用产生了巨大的影响。在近700种颅面畸形综合征中，有Saethre-Chotzen、Apert、Treacher柯林斯、Pierre Robin和Waardenburg综合征。影响颅缝、腭、牙齿和颌的非综合征性疾病也很常见。综合征和非综合征的颅面疾病对受影响的个体以及家庭成员和照顾者的一生都有重大影响。治疗通常必须多管齐下，包括手术，牙科护理和多年的心理咨询。这些方法成本高昂，尽管它们可以带来显著的好处，但往往并不完全成功。因此，主要的努力需要针对开发预防和改善修复的组织工程方法的治疗途径。新的治疗方法只能来自对个体畸形综合征的病因学和病理生理学的深入理解，这是建立在对调节颅面发育的正常事件的透彻理解的基础上的。为此，我们寻求资助2012年戈登研究会议（GRC）颅面形态和组织再生和随之而来的戈登凯南研究研讨会（GRS）。GRC已成为颅面发育和疾病的首要国际会议。GRS于2010年在意大利的il Ciocco首次与GRC一起举行，为博士后研究员和研究生提供了在严格但小型和支持性环境中展示其工作的机会。该提案的长期目标是促进科学界的凝聚力，该科学界将对颅面复合体的发展以及影响颅面结构和功能的疾病的病理生理学和治疗进行基础和转化研究。由于颅面发育和疾病是复杂的，知之甚少，跨学科的方法是必不可少的。众所周知，转型研究发生在学科之间的接口。因此，将在发育生物学、干细胞生物学、人类遗传学和组织工程等不同但相关学科工作的科学家聚集在一起，对于颅面疾病治疗取得真实的进展至关重要。 与公共卫生的相关性：头部和面部的缺失约占所有出生缺陷的三分之一。它们也是婴儿死亡的主要原因，并对全国保健费用产生巨大影响。这些疾病的治疗往往很复杂，可能是终身的，对家庭成员和照顾者以及受影响的个人都有重大影响。为了设计治疗这些疾病的新方法，必须将在发育生物学，干细胞生物学，人类遗传学和组织工程等不同但相关学科中工作的科学家聚集在一起，以促进互动和合作。为此，我们寻求资助2012年戈登研究会议（GRC）颅面形态和组织再生和随之而来的戈登凯南研究研讨会（GRS），将在文图拉，加利福尼亚州，2012年3月18日至23日。

DESCRIPTION (provided by applicant): Craniofacial abnormalities are common birth defects, accounting for approximately one third of all congenital anomalies. They are also a major cause of infant mortality. Collectively they have a dramatic impact on the cost of health care nationally. Among the nearly 700 craniofacial malformation syndromes are disorders such as Saethre-Chotzen, Apert, Treacher Collins, Pierre Robin and Waardenburg syndromes. Non-syndromic disorders that affect the cranial sutures, palate, teeth and jaw are also common. Craniofacial disorders, both syndromic and non-syndromic, have major consequences over the lifetimes of affected individuals, as well as family members and caregivers. Treatments must often be multi-pronged, involving surgery, dental care, and psychological counseling over many years. These approaches are costly and, although they can have significant benefit, they are too often not entirely successful. Therefore major effort needs to be directed towards developing therapeutic avenues for prevention and improving tissue engineering approaches for repair. New therapeutic approaches can only come from a deep understanding of the etiology and pathophysiology of individual malformation syndromes, which is built upon a thorough understanding of the normal events that regulate craniofacial development. To this end, we seek funding for the 2012 Gordon Research Conference (GRC) on Craniofacial Morphogenesis and Tissue Regeneration and the accompanying Gordon-Kenan Research Seminar (GRS). The GRC has become the premier international conference on craniofacial development and disease. The GRS, which first took place in conjunction with the GRC at il Ciocco, Italy in 2010, provides opportunities for postdoctoral fellows and graduate students to present their work in a rigorous yet small and supportive setting. The long term goal of this proposal is to contribute to the cohesion of a scientific community that will conduct basic and translational research on the development of the craniofacial complex and the pathophysiology and treatment of diseases that affect craniofacial structure and function. Because craniofacial development and disease are complex and poorly understood, interdisciplinary approaches are essential. It is well established that transformational studies take place at the interfaces between disciplines. Therefore bringing together scientists working in the diverse yet related disciplines of developmental biology, stem cell biology, human genetics, and tissue engineering is essential for making real progress on the treatment of craniofacial disease. PUBLIC HEALTH RELEVANCE: Abnormalities of the head and face account for approximately one third of all birth defects. They are also a major cause of infant mortality, and have a dramatic impact on the cost of health care nationally. Treatment of such disorders is often complex and can be life-long, with major consequences for family members and caregivers, as well as affected individuals. To devise new approaches for the treatment of such disorders, it is essential together scientists working in the diverse yet related disciplines of developmental biology, stem cell biology, human genetics, and tissue engineering in a setting that fosters interaction and collaboration. To this end, we seek funding for the 2012 Gordon Research Conference (GRC) on Craniofacial Morphogenesis and Tissue Regeneration and the accompanying Gordon-Kenan Research Seminar (GRS) which will take place in Ventura, CA, March 18-23, 2012.