Genetics Core

遗传学核心

• 批准号: 8382612
• 负责人: DAVID VALLE
• 金额: $ 29.47万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8382612
• 关键词: Achievement; Address; Amino Acid Sequence; Behavioral; Biochemical; Bioinformatics; Biological; Biomedical Research; Cell Culture Techniques; Cell Line; Chromosomal Duplication; Chromosome Deletion; Cognitive; Complement; Computer software; Consent; Copy Number Polymorphism; Cryopreservation; Custom; Cytogenetic Analysis; Cytogenetics; DNA; DNA analysis; Data; Databases; Development; Disease; Documentation; Evaluation; Fibroblasts; Fluorescent in Situ Hybridization; Generations; Genes; Genetic; Genetic Medicine; Genome; Genomics; Genotype; Grant; Human Genome Project; Institutes; Investigation; Liquid substance; Maintenance; Maps; Mental Retardation and Developmental Disabilities Research Centers; Molecular; Molecular Biology; Molecular Cytogenetics; Molecular Genetics; Nitrogen; Patients; Peptide Sequence Determination; Phenotype; Preparation; Research; Research Personnel; Resolution; Resources; Retrieval; Role; SNP genotyping; Sampling; Science; Scientific Advances and Accomplishments; Services; Software Tools; Time; Universities; base; design; follow-up; genome wide association study; high standard; lymphoblast; markov model; medical schools; programs; response; tissue culture; tool

Investigators from the Kennedy Krieger Institute (KKI), the McKusick-Nathans Institute of Genetic Medicine (IGM) and The Johns Hopkins University School of Medicine (JHUSOM) utilize the Genetics Core of the MRDDRC (MRDD-GC) as a resource in their efforts to better understand the role of genetic factors associated with normal and abnormal physical, cognitive and/or behavioral development. The MRDD-GC has been part of the MRDDRC since its inception in 1988. Since that time developments in the fields of genetics and molecular biology have occurred that have literally revolutionized the biomedical research enterprise. Most visibly, the Human Genome Project had not yet started in 1988, and its findings, as well as the technoligies that have emerged for conducting genome-wide studies, have had immense impacts. As the following Core description will illustrate, our capabilities and programs of supported reseach have kept abreast of these developments, and we have maintained state-of-the-science facilities and expertise throughout these recent decades of rapid scientific advances and technological achievements.

肯尼迪·克里格研究所（KKI）的调查人员，麦克库西克 - 纳坦人遗传医学研究所 （IGM）和约翰·霍普金斯大学医学院（Jhusom）利用了遗传学核心 MRDDRC（MRDD-GC）作为他们努力更好地了解遗传因素的作用的资源 具有正常和异常的身体，认知和/或行为发展。 MRDD-GC已成为 MRDDRC自1988年成立以来。自那时以来，遗传学和分子领域的发展 生物学已经发生了，从字面上彻底改变了生物医学研究企业。最明显的是 人类基因组项目尚未于1988年开始，其发现以及具有的技术 出现用于进行全基因组研究的出现，具有巨大的影响。作为以下核心描述 会说明，我们的能力和支持的参议员与这些发展保持一致， 在过去的几十年中，我们一直保持科学设施和专业知识 科学进步和技术成就。