Genes, Gendered Contexts, and Substance Use Outcomes

基因、性别背景和药物使用结果

基本信息

批准号：
8298516
负责人：
EDELYN VERONA
金额：
$ 18.36万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-15 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8298516
关键词：
Address Adolescent Adult Alcohol or Other Drugs use Behavior Biological Biology Brain Child Abuse Child Sexual Abuse Childhood Country Crime DRD4 gene Data Development Disadvantaged Drug abuse Drug usage Economics Education Electroencephalography Environment Environmental Risk Factor Etiology Female Future Gender Gene Expression Genes Genetic Genotype Goals Individual Intervention Measures Mediating Mediator of activation protein Mental Depression Modeling Monoamine Oxidase A Neighborhoods Outcome Outcome Measure Pathway interactions Pharmaceutical Preparations Pharmacological Treatment Prostitution Psychopathology Psychophysiology Recording of previous events Relative (related person)Research Risk Factors Rosa Sex Characteristics Social Problems Specific qualifier value Symptoms Woman Work anti social drug relapse follow-up innovation intimate partner violence male men monoamine neuromechanism offspring prospective psychosocial serotonin transporter sex statistics treatment program trend

项目摘要

DESCRIPTION (provided by applicant): It is becoming increasingly clear that risk factors for use and trajectories toward desistance may differ significantly for men and women (e.g., Westermeyer & Boedicker, 2000). For example, recent work has uncovered different effects of monoamine genotypes (e.g., serotonin transporter, MAO-A) on male and female psychopathology and behavior (Sjoberg et al., 2007a; Verona, Joiner, Johnson & Bender, 2006). In addition, there is evidence that pubertal onset, childhood sexual abuse, and intimate partner violence (IPV) constitute unique risk factors for antisocial behavior and drug use among women compared to men (Dick, Rose, Kaprio, & Viken, 2000) and can predict drug relapse in women many years later in adulthood (Hyman, Garcia, & Sinha, 2006). Thus, a primary goal of the present application is to identify gender differences in biological and environmental risk factors for substance use outcomes as a way of advancing nuanced conceptualizations of female drug problems. The current project intends to (1) explore various gene by environment (GxE) effects on drug use outcomes, by examining different monoamine genes (5HTT, DRD4, MAO-A) and incorporating gendered environmental risk factors that are not commonly included in studies of drug use (e.g., intimate partner violence), (2) examine the extent to which GxE effects or individual risk factors are specific to substance use outcomes in women relative to men, and (3) identify multivariate models involving GxE effects and mediators of these effects to predict substance use pathways in men and women. The goal is to examine not only GxE effects (e.g., gene-by-abuse, gene-by-IPV) that directly influence substance use outcomes, but identify potential mediators (pubertal development, internalizing symptoms) in an effort to understand nuanced pathways for female substance use. The ultimate goal is to help in the development of tailored interventions to address gender-specific manifestations and etiologies.

描述（由申请人提供）：越来越清楚的是，男性和女性使用和轨迹的使用危险因素可能有很大差异（例如Westermeyer＆Boedicker，2000年）。例如，最近的工作发现了单胺基因型（例如5-羟色胺转运蛋白，MAO-A）对男性和女性心理病理学和行为的不同影响（Sjoberg等，2007a； Verona，Joiner，Joiner，Johnson＆Bender，2006）。此外，有证据表明，与男性相比，青春期发作，儿童性虐待和亲密伴侣暴力（IPV）构成了女性反社会行为和药物使用的独特风险因素（Dick，Rose，Rose，Kaprio，＆Viken，＆Viken，2000年），并且可以预测多年以后女性的药物复发（Hyman，Garcia，Garcia和Sinha，＆Sinha，＆Sinha，＆Sinha，2006年）。因此，本应用的主要目标是确定物质使用结果的生物学和环境风险因素的性别差异，以推动女性药物问题的细微概念化。当前的项目打算（1）通过检查不同的单胺基因（5HTT，DRD4，MAO-A）来探索对药物使用结果的各种基因（GXE）对药物使用结果的影响，并纳入不常见的性别环境风险因素，而性别危险因素通常不包括在药物使用研究中（例如，与亲密的伴侣暴力）相对范围或范围造成范围的范围，（2）（2）（2）（2）（2）（2）（2）（2）（2）（2）（2）（2）（2）（2）（2）（2）（2）（2）男性，以及（3）确定涉及GXE效应和这些效应的介体的多元模型，以预测男性和女性的物质使用途径。目的是不仅检查直接影响物质使用结果的GXE效应（例如，基因，基因，基因by-ipv），还可以确定潜在的介体（青春期发育，内部化症状），以了解女性药物使用的细微途径。最终目标是帮助制定量身定制的干预措施，以解决特定性别的表现和病因。