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Clinical and Preclinical Models in Drug Abuse: Training and Development

药物滥用的临床和临床前模型：培训和开发

基本信息

批准号：
8286888
负责人：
Richard W Foltin
金额：
$ 12.82万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8286888
关键词：
Accounting Advocate Aerobic Exercise Affect Aging Agonist Amphetamines Appetite Depressants Area Banana Behavior Behavioral Behavioral Mechanisms Brain Candy Chronic Clinical Cocaine Cocaine Abuse Cocaine Users Cognition Consumption Corpus striatum structure Cues Development Dimensions Disease Doctor of Philosophy Dopamine D2 Receptor Dose Drug abuse Drug usage Eating Eating Disorders Ecology Exercise Faculty Fellowship Food Funding Geriatric Psychiatry Goals Hippocampus (Brain)Human Human Volunteers Individual Intake Intervention Intravenous K-Series Research Career Programs Laboratories Laboratory Animals Laboratory Rat Lead Learning Macaca mulatta Magnetic Resonance Imaging Maintenance Measures Mentors Mentorship Methamphetamine Methodology Modafinil Modeling Monkeys Moods Motivation Neuropsychology Obesity Outcome Pharmaceutical Preparations Pilot Projects Play Positron-Emission Tomography Pre-Clinical Model Procedures Public Health Publications Raclopride Rattus Relapse Reporting Research Research Project Grants Resistance Resources Role Self Administration Self-Administered Senior Scientist Senior Scientist Award Series Smoke Smoker Smoking Stress Time Training Ursidae Family Wages Work base cocaine use cognitive function design drug relapse experience food consumption food flavor hypocretin improved interest methamphetamine abuse neurochemistry nonhuman primate novel strategies novel therapeutic intervention paired stimuli pre-clinical programs radiotracer reinforced behavior reinforcer response sedentary stressor translational approach transmission process

项目摘要

DESCRIPTION (provided by applicant): The purpose of this Senior Scientist Research and Mentorship Award (K05) application is to allow me (Richard W. Foltin, Ph.D.) protected time so that I may continue to mentor junior faculty. In this way I will share with the junior faculty much of what I learned from my mentors and in turn have my research benefit from what I learn from the junior faculty. Specifically, I will share my experience in conducting well-controlled, laboratory- based studies in areas that are difficult to model (relapse, putative medication effects on drug self- administration, estimating reinforcing values of behavior) with junior colleagues who are hoping to bring similar powerful methodologies to bear on their areas of expertise. Goal 1. Research: Aim 1. Maintain active research programs using laboratory models of drug abuse in non-human primates and drug-experienced human volunteers. My active support has always played a role in providing both research opportunities and salary support for junior faculty. I have 2 active R01s and 2 pending R01 submissions that will be used to support my research and provide training opportunities. Aim 2. Expand my research interests by incorporating the expertise of junior faculty I am mentoring in neuropsychology, magnetic resonance imaging, eating disorders and geriatric psychiatry. Goal 2. Training: Aim 1. Continue to be a valuable resource to the more senior faculty in our research group whom I have mentored since they completed their postdoctoral fellowships. Aim 2. Help the individuals whom I mentored on their K awards who are in their 4th and 5th years and now transitioning to independent status. Aim 3. Provide guidance to the individuals whom I mentor that are in the first several years of their K awards. Aim 4. Keep a discernible profile in departmental affairs so that I can be an advocate for drug abuse research and the needs of junior faculty. I have sufficient mentoring responsibilities to account for my mentoring effort over the next 5 years. Generally the junior faculty I mentor will first conduct projects that will be funded as part of one of my R01s, and then apply for divisional funds for pilot studies where possible prior to submitting a K application. This model has worked well in the past and will be used to develop new K awards for junior faculty.

描述（由申请人提供）：此高级科学家研究和指导奖（K05）申请的目的是让我（理查德·W·福尔廷博士）有受保护的时间，以便我可以继续指导初级教师。通过这种方式，我将与初级教师分享我从导师那里学到的大部分知识，反过来，我的研究也会从我从初级教师那里学到的东西中受益。具体来说，我将与初级同事分享我在难以建模的领域（复发、假定的药物对药物自我管理的影响、估计行为的强化价值）进行良好控制的、基于实验室的研究的经验，他们希望将类似的强大方法应用于他们的专业领域。目标 1. 研究：目的 1. 利用非人类灵长类动物和有药物经验的人类志愿者的药物滥用实验室模型维持积极的研究计划。我的积极支持一直在为初级教师提供研究机会和薪资支持方面发挥着作用。我有 2 个有效的 R01 和 2 个待提交的 R01，它们将用于支持我的研究并提供培训机会。目标 2. 通过整合我所指导的初级教师在神经心理学、磁共振成像、饮食失调和老年精神病学方面的专业知识来扩大我的研究兴趣。目标 2. 培训：目标 1. 继续成为我们研究组中更高级的教师的宝贵资源，自从他们完成博士后奖学金以来我一直在指导他们。目标 2. 帮助我指导的获得 K 奖的个人，他们正处于第四年和第五年，现在正在过渡到独立身份。目标 3. 为我指导的 K 奖头几年的个人提供指导。目标 4. 在部门事务中保持明显的形象，以便我能够成为药物滥用研究和初级教师需求的倡导者。我有足够的指导责任来承担我未来 5 年的指导工作。一般来说，我指导的初级教师将首先开展作为我的 R01 的一部分资助的项目，然后在提交 K 申请之前尽可能申请部门资金进行试点研究。这种模式过去运作良好，将用于为初级教师制定新的 K 奖。