Clinical and Preclinical Models in Drug Abuse: Training and Development

药物滥用的临床和临床前模型：培训和开发

• 批准号: 8685228
• 负责人: Richard W Foltin
• 金额: $ 12.82万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8685228
• 关键词: Accounting; Advocate; Aerobic Exercise; Affect; Aging; Agonist; Amphetamines; Appetite Depressants; Area; Banana; Behavior; Behavioral; Behavioral Mechanisms; Brain; Candy; Chronic; Clinical; Cocaine; Cocaine Abuse; Cocaine Users; Cognition; Consumption; Corpus striatum structure; Cues; Development; Dimensions; Disease; Doctor of Philosophy; Dopamine D2 Receptor; Dose; Drug abuse; Drug usage; Eating; Eating Disorders; Ecology; Exercise; Faculty; Fellowship; Food; Funding; Geriatric Psychiatry; Goals; Hippocampus (Brain); Human; Human Volunteers; Individual; Intake; Intervention; Intravenous; K-Series Research Career Programs; Laboratories; Laboratory Animals; Laboratory Rat; Lead; Learning; Macaca mulatta; Magnetic Resonance Imaging; Maintenance; Measures; Mentors; Mentorship; Methamphetamine; Methodology; Modafinil; Modeling; Monkeys; Moods; Motivation; Neuropsychology; Obesity; Outcome; Pharmaceutical Preparations; Pilot Projects; Play; Positron-Emission Tomography; Pre-Clinical Model; Procedures; Public Health; Publications; Raclopride; Rattus; Relapse; Reporting; Research; Research Project Grants; Resistance; Resources; Role; Self Administration; Self-Administered; Senior Scientist; Senior Scientist Award; Series; Smoke; Smoker; Smoking; Stress; Time; Training; Ursidae Family; Wages; Work; base; cocaine use; cognitive function; design; drug relapse; experience; food consumption; food flavor; hypocretin; improved; interest; methamphetamine abuse; neurochemistry; nonhuman primate; novel strategies; novel therapeutic intervention; paired stimuli; pre-clinical; programs; radiotracer; reinforced behavior; reinforcer; response; sedentary; stressor; translational approach; transmission process

DESCRIPTION (provided by applicant): The purpose of this Senior Scientist Research and Mentorship Award (K05) application is to allow me (Richard W. Foltin, Ph.D.) protected time so that I may continue to mentor junior faculty. In this way I will share with the junior faculty much of what I learned from my mentors and in turn have my research benefit from what I learn from the junior faculty. Specifically, I will share my experience in conducting well-controlled, laboratory- based studies in areas that are difficult to model (relapse, putative medication effects on drug self- administration, estimating reinforcing values of behavior) with junior colleagues who are hoping to bring similar powerful methodologies to bear on their areas of expertise. Goal 1. Research: Aim 1. Maintain active research programs using laboratory models of drug abuse in non-human primates and drug-experienced human volunteers. My active support has always played a role in providing both research opportunities and salary support for junior faculty. I have 2 active R01s and 2 pending R01 submissions that will be used to support my research and provide training opportunities. Aim 2. Expand my research interests by incorporating the expertise of junior faculty I am mentoring in neuropsychology, magnetic resonance imaging, eating disorders and geriatric psychiatry. Goal 2. Training: Aim 1. Continue to be a valuable resource to the more senior faculty in our research group whom I have mentored since they completed their postdoctoral fellowships. Aim 2. Help the individuals whom I mentored on their K awards who are in their 4th and 5th years and now transitioning to independent status. Aim 3. Provide guidance to the individuals whom I mentor that are in the first several years of their K awards. Aim 4. Keep a discernible profile in departmental affairs so that I can be an advocate for drug abuse research and the needs of junior faculty. I have sufficient mentoring responsibilities to account for my mentoring effort over the next 5 years. Generally the junior faculty I mentor will first conduct projects that will be funded as part of one of my R01s, and then apply for divisional funds for pilot studies where possible prior to submitting a K application. This model has worked well in the past and will be used to develop new K awards for junior faculty.

描述（由申请人提供）：这个高级科学家研究和导师奖（K05）申请的目的是让我（理查德W。Foltin博士）这样我就可以继续指导初级教员了通过这种方式，我将与初级教师分享我从导师那里学到的很多东西，反过来，我的研究也将受益于我从初级教师那里学到的东西。具体来说，我将与希望将类似的强大方法应用于其专业领域的初级同事分享我在难以建模的领域（复发、药物对自我给药的假定作用、行为强化价值的估计）进行良好控制的实验室研究的经验。 目标1.研究：目标1。在非人类灵长类动物和有药物经验的人类志愿者中使用药物滥用的实验室模型，保持积极的研究计划。我的积极支持一直在提供研究机会和工资支持初级教师的作用。我有2个活跃的R01和2个待定的R01提交，将用于支持我的研究和提供培训机会。目标2.通过结合我在神经心理学、磁共振成像、饮食失调和老年精神病学方面指导的初级教师的专业知识来扩大我的研究兴趣。 目标2.培训：目标1。继续成为我们研究小组中更资深的教师的宝贵资源，自从他们完成博士后研究以来，我一直指导他们。目标二。帮助那些我在K奖上指导过的人，他们在第四和第五年，现在正在向独立身份过渡。目标3。为我所指导的处于K奖前几年的个人提供指导。目标4。在部门事务中保持明显的形象，这样我就可以成为药物滥用研究和初级教师需求的倡导者。 我有足够的指导责任来说明我在未来5年的指导工作。一般来说，我指导的初级教师将首先进行项目，这些项目将作为我的R01的一部分得到资助，然后在提交K申请之前，在可能的情况下申请部门资金进行试点研究。这种模式在过去一直运作良好，并将用于开发新的K奖的初级教师。