Clinical and Preclinical Models in Drug Abuse: Training and Development

药物滥用的临床和临床前模型：培训和开发

基本信息

批准号：
8685228
负责人：
Richard W Foltin
金额：
$ 12.82万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8685228
关键词：
Accounting Advocate Aerobic Exercise Affect Aging Agonist Amphetamines Appetite Depressants Area Banana Behavior Behavioral Behavioral Mechanisms Brain Candy Chronic Clinical Cocaine Cocaine Abuse Cocaine Users Cognition Consumption Corpus striatum structure Cues Development Dimensions Disease Doctor of Philosophy Dopamine D2 Receptor Dose Drug abuse Drug usage Eating Eating Disorders Ecology Exercise Faculty Fellowship Food Funding Geriatric Psychiatry Goals Hippocampus (Brain)Human Human Volunteers Individual Intake Intervention Intravenous K-Series Research Career Programs Laboratories Laboratory Animals Laboratory Rat Lead Learning Macaca mulatta Magnetic Resonance Imaging Maintenance Measures Mentors Mentorship Methamphetamine Methodology Modafinil Modeling Monkeys Moods Motivation Neuropsychology Obesity Outcome Pharmaceutical Preparations Pilot Projects Play Positron-Emission Tomography Pre-Clinical Model Procedures Public Health Publications Raclopride Rattus Relapse Reporting Research Research Project Grants Resistance Resources Role Self Administration Self-Administered Senior Scientist Senior Scientist Award Series Smoke Smoker Smoking Stress Time Training Ursidae Family Wages Work base cocaine use cognitive function design drug relapse experience food consumption food flavor hypocretin improved interest methamphetamine abuse neurochemistry nonhuman primate novel strategies novel therapeutic intervention paired stimuli pre-clinical programs radiotracer reinforced behavior reinforcer response sedentary stressor translational approach transmission process

项目摘要

DESCRIPTION (provided by applicant): The purpose of this Senior Scientist Research and Mentorship Award (K05) application is to allow me (Richard W. Foltin, Ph.D.) protected time so that I may continue to mentor junior faculty. In this way I will share with the junior faculty much of what I learned from my mentors and in turn have my research benefit from what I learn from the junior faculty. Specifically, I will share my experience in conducting well-controlled, laboratory- based studies in areas that are difficult to model (relapse, putative medication effects on drug self- administration, estimating reinforcing values of behavior) with junior colleagues who are hoping to bring similar powerful methodologies to bear on their areas of expertise. Goal 1. Research: Aim 1. Maintain active research programs using laboratory models of drug abuse in non-human primates and drug-experienced human volunteers. My active support has always played a role in providing both research opportunities and salary support for junior faculty. I have 2 active R01s and 2 pending R01 submissions that will be used to support my research and provide training opportunities. Aim 2. Expand my research interests by incorporating the expertise of junior faculty I am mentoring in neuropsychology, magnetic resonance imaging, eating disorders and geriatric psychiatry. Goal 2. Training: Aim 1. Continue to be a valuable resource to the more senior faculty in our research group whom I have mentored since they completed their postdoctoral fellowships. Aim 2. Help the individuals whom I mentored on their K awards who are in their 4th and 5th years and now transitioning to independent status. Aim 3. Provide guidance to the individuals whom I mentor that are in the first several years of their K awards. Aim 4. Keep a discernible profile in departmental affairs so that I can be an advocate for drug abuse research and the needs of junior faculty. I have sufficient mentoring responsibilities to account for my mentoring effort over the next 5 years. Generally the junior faculty I mentor will first conduct projects that will be funded as part of one of my R01s, and then apply for divisional funds for pilot studies where possible prior to submitting a K application. This model has worked well in the past and will be used to develop new K awards for junior faculty.

描述（由申请人提供）：该高级科学家研究与指导奖（K05）申请的目的是允许我（Richard W. Foltin，Ph.D.）受保护的时间，以便我可以继续指导初级教师。通过这种方式，我将与初级教师分享我从导师中学到的许多知识，然后从初级教师那里学到的知识从我的研究中受益。具体而言，我将分享我在难以模拟的领域（复发，推定对药物自我管理的推定药物影响，估算行为的效果）的领域中进行基于实验室的研究经验，他们希望与希望带来类似强大的方法论能够在其专业领域中忍受类似的强大方法。目标1。研究：目标1。使用非人类灵长类动物和毒品经验丰富的人类志愿者中的药物滥用实验室模型维护活跃的研究计划。我的积极支持一直在为初级教师提供研究机会和工资支持方面发挥了作用。我有2个活跃的R01和2个待定的R01提交，这些内容将用于支持我的研究并提供培训机会。 AIM 2。通过纳入我正在指导神经心理学，磁共振成像，饮食失调和老年精神病学的初级教师的专业知识来扩展我的研究兴趣。目标2。培训：目标1。自从他们完成博士后研究金以来，我一直在指导我们的研究小组中更高级教师的宝贵资源。 AIM 2。帮助我指导的个人在第四和第五年的K奖项中，现在已经过渡到独立地位。 AIM 3。向我指导的K奖的头几年的个人提供指导。 AIM 4。在部门事务中保持可辨认的概况，以便我可以倡导滥用药物研究和初级教师的需求。我有足够的指导责任来说明未来5年的指导工作。通常，初级教师I导师将首先进行将作为我的R01之一的一部分资助的项目，然后在提交K申请之前，在可能的情况下向试点研究申请分区资金。该模型过去效果很好，将用于为初级教师开发新的K奖。