Clinical and Preclinical Models in Drug Abuse: Training and Development

描述(由申请人提供)：本高级科学家研究和导师奖(K05)申请的目的是允许我(Richard W.Foltin，Ph.D.)受保护的时间，这样我就可以继续指导初级教员。通过这种方式，我将与初级教员分享我从导师那里学到的许多东西，进而使我的研究受益于我从初级教员那里学到的东西。具体地说，我将与初级同事分享我在难以建模的领域(复发、假定的药物对药物自我管理的影响、评估强化的行为价值观)进行良好控制的、基于实验室的研究的经验，他们希望将类似的强大方法应用于他们的专业领域。目标1.研究：目标1.使用非人类灵长类动物和有药物经验的人类志愿者滥用药物的实验室模型，维持积极的研究计划。我的积极支持一直在为初级教员提供研究机会和工资支持方面发挥作用。我有两个有效的R01和两个待定的R01提交，将用于支持我的研究和提供培训机会。目标2.通过吸收我正在指导的初级教员在神经心理学、磁共振成像、进食障碍和老年精神病学方面的专业知识，扩大我的研究兴趣。目标2.培训：目标1.对于我们研究小组中更资深的教员来说，继续是一项宝贵的资源，我在他们完成博士后研究后一直在指导他们。目标2.帮助我在K奖项上指导的那些4岁和5岁，现在正在过渡到独立状态的人。目标3.为我所指导的个人提供指导，这些人在获得K奖项的头几年。目标4.在部门事务中保持清晰的形象，这样我就可以成为药物滥用研究和初级教员需求的倡导者。我有足够的指导责任来解释我在接下来的5年里的指导努力。一般来说，我指导的初级教员将首先进行项目，这些项目将作为我的R01之一的一部分得到资助，然后在提交K申请之前，如果可能的话，申请用于试点研究的部门资金。这一模式在过去运作良好，并将被用于为初级教师开发新的K奖。

DESCRIPTION (provided by applicant): The purpose of this Senior Scientist Research and Mentorship Award (K05) application is to allow me (Richard W. Foltin, Ph.D.) protected time so that I may continue to mentor junior faculty. In this way I will share with the junior faculty much of what I learned from my mentors and in turn have my research benefit from what I learn from the junior faculty. Specifically, I will share my experience in conducting well-controlled, laboratory- based studies in areas that are difficult to model (relapse, putative medication effects on drug self- administration, estimating reinforcing values of behavior) with junior colleagues who are hoping to bring similar powerful methodologies to bear on their areas of expertise. Goal 1. Research: Aim 1. Maintain active research programs using laboratory models of drug abuse in non-human primates and drug-experienced human volunteers. My active support has always played a role in providing both research opportunities and salary support for junior faculty. I have 2 active R01s and 2 pending R01 submissions that will be used to support my research and provide training opportunities. Aim 2. Expand my research interests by incorporating the expertise of junior faculty I am mentoring in neuropsychology, magnetic resonance imaging, eating disorders and geriatric psychiatry. Goal 2. Training: Aim 1. Continue to be a valuable resource to the more senior faculty in our research group whom I have mentored since they completed their postdoctoral fellowships. Aim 2. Help the individuals whom I mentored on their K awards who are in their 4th and 5th years and now transitioning to independent status. Aim 3. Provide guidance to the individuals whom I mentor that are in the first several years of their K awards. Aim 4. Keep a discernible profile in departmental affairs so that I can be an advocate for drug abuse research and the needs of junior faculty. I have sufficient mentoring responsibilities to account for my mentoring effort over the next 5 years. Generally the junior faculty I mentor will first conduct projects that will be funded as part of one of my R01s, and then apply for divisional funds for pilot studies where possible prior to submitting a K application. This model has worked well in the past and will be used to develop new K awards for junior faculty.