Baylor College of Medicine Adolescent Medicine Trials Unit

描述（由申请人提供）：贝勒医学院 (BCM) 正在申请青少年医学试验单位 (ATU)，以响应 NIH RFA-HD-10-015 HIV/AIDS 干预青少年医学试验网络。 BCM 试验部门计划通过提供经验丰富的研究团队来规划、招募、分析和发布研究试验结果（包括行为研究、社区需求评估和治疗试验），同时满足艾滋病毒感染青少年的临床和行为需求，从而为 ATN 的研究议程做出贡献。 BCM ATU 将拥有三种患者资源： 1) 德克萨斯儿童医院 (TCH) 的青少年诊所，由 Paul 和 Schwarzwald 博士领导，分别是 BCM 儿科的过敏和免疫学科以及逆转录病毒学科； 2) Thomas Street Clinic (TSC) 艾滋病毒感染青少年诊所，由 Schwarzwald 博士领导； 3) 医疗家庭诊所项目，由 BCM 儿科 Desiree Evans 博士领导，为休斯顿医疗服务匮乏的地区提供青少年护理。 BCM 将有 225 名 HIV 感染青少年和超过 1000 名 12-24 岁的高危青少年参加旨在预防 HIV 的干预试验，针对 HIV 感染者、青春期前儿童、青少年和年轻人的高危人群进行一级预防以及二级和三级预防。 BCM 提出了独特的研究，包括创新性地使用二级预防艾滋病毒传播的技术和青少年遵守艾滋病毒药物治疗方案，一项药代动力学研究，以评估抗抑郁药与抗逆转录病毒药物在感染艾滋病毒的青少年中使用时的相互作用，以及一项通过由市卫生部门和社区艾滋病组织主办的大型、面向青少年的社区测试活动，评估与护理被确定为艾滋病毒感染的青少年的联系的研究。 BCM ATU 拥有临床、行为和研究能力以及与社区的联系，可以参与多项旨在预防青少年艾滋病毒的试验以及旨在改善艾滋病毒感染青少年的管理和社会心理功能的试验。 相关性：休斯顿及周边县的青少年是美国艾滋病毒感染率增长最快的县之一。贝勒医学院 (BCM) 申请成为青少年医学试验单位与公共卫生相关，因为 BCM 计划实施旨在促进艾滋病毒高危青少年的一级预防以及艾滋病毒感染青少年的二级和三级预防的试验。

DESCRIPTION (provided by applicant): Baylor College of Medicine (BCM) is applying for an Adolescent Medicine Trials Unit (ATU) in response to NIH RFA-HD-10-015 Adolescent Medicine Trials Network for HIV/AIDS Interventions. The BCM Trials Unit plans to contribute to the ATN's research agenda by providing an experienced research team to plan, enroll, analyze and publish results of research trials including behavioral research studies, community needs assessments, and therapeutic trials while meeting clinical and behavioral needs of HIV-infected youth. The BCM ATU will have three resources of patients: 1) Teen Clinics for HIV-infected youth at Texas Children's Hospital (TCH) lead by Drs Paul and Schwarzwald, Sections of Allergy and Immunology, and Retrovirology respectively, Department of Pediatrics, BCM; 2) Thomas Street Clinic (TSC) HIV-infected youth clinic lead by Dr Schwarzwald; and 3) Project Medical Home Clinics which provide adolescent care in medically underserved areas of Houston lead by Dr Desiree Evans, Department of Pediatrics, BCM. BCM will have 225 HIV-infected adolescents and over 1000 at-risk adolescents who are 12-24 years of age available to approach for enrollment into intervention trials aimed at the prevention of HIV, primary prevention In at-risk and secondary and tertiary prevention in the HIV-infected, pre-adolescents, adolescents, and young adults. BCM proposes unique studies involving innovative use of technology for secondary prevention of HIV transmission and adherence to HIV medication regimens among youth, a study of the pharmacokinetics to evaluate interactions of antidepressants when used with antiretroviral medications in HIV-infected youth, and a study that evaluates linkage to care for youth identified as HIV-infected through a large, youth oriented community testing event sponsored by the city health department and a community based AIDS organization. BCM ATU has the clinical, behavioral and research capacities and linkages to community to participate in multiple trials aimed at prevention of HIV in youth and trials aimed at improvements in management and psychosocial functioning of HIV-infected youth. RELEVANCE: Youth in Houston and surrounding counties have one of the fastest growing rates of HIV-infection in the United States. Baylor College of Medicine (BCM)'s application to become an Adolescent Medicine Trials Unit is relevant to public health in that BCM plans to implement trials designed to promote primary prevention in HIV at-risk and secondary and tertiary prevention in HIV-infected youth.