Baylor College of Medicine Adolescent Medicine Trials Unit

贝勒医学院青少年医学试验单位

• 批准号: 8440209
• 负责人: MARY E PAUL
• 金额: $ 34.51万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-07 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8440209
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adherence; Adolescent; Adolescent Medicine; Adolescent Medicine Trials Network; Age-Years; Anti-Retroviral Agents; Antidepressive Agents; Area; Behavioral; Behavioral Research; Caring; Cities; Clinic; Clinic Visits; Clinical; Clinical Trials Design; Collaborations; Communities; County; Drug Kinetics; Enrollment; Event; HIV; HIV Infections; Health; Home environment; Hypersensitivity; Immunology; Intervention; Intervention Trial; Lead; Medical; Medically Underserved Area; Medicine; Needs Assessment; Online Systems; Patients; Pediatric Hospitals; Pharmaceutical Preparations; Primary Prevention; Principal Investigator; Public Health; Publishing; Regimen; Request for Applications; Research; Research Personnel; Resources; Retrovirology; Risk; Risk Reduction; Safe Sex; Secondary Prevention; Structure; Technology; Teenagers; Testing; Texas; Therapeutic; Therapy Clinical Trials; United States; Youth; antiretroviral therapy; base; clinical research site; college; community organizations; design; experience; improved; innovation; interactive multimedia; meetings; outreach; pediatric department; programs; psychosocial; research study; response; sexually active; skills training; tertiary prevention; theories; therapy adherence; transmission process; young adult

DESCRIPTION (provided by applicant): Baylor College of Medicine (BCM) is applying for an Adolescent Medicine Trials Unit (ATU) in response to NIH RFA-HD-10-015 Adolescent Medicine Trials Network for HIV/AIDS Interventions. The BCM Trials Unit plans to contribute to the ATN's research agenda by providing an experienced research team to plan, enroll, analyze and publish results of research trials including behavioral research studies, community needs assessments, and therapeutic trials while meeting clinical and behavioral needs of HIV-infected youth. The BCM ATU will have three resources of patients: 1) Teen Clinics for HIV-infected youth at Texas Children's Hospital (TCH) lead by Drs Paul and Schwarzwald, Sections of Allergy and Immunology, and Retrovirology respectively, Department of Pediatrics, BCM; 2) Thomas Street Clinic (TSC) HIV-infected youth clinic lead by Dr Schwarzwald; and 3) Project Medical Home Clinics which provide adolescent care in medically underserved areas of Houston lead by Dr Desiree Evans, Department of Pediatrics, BCM. BCM will have 225 HIV-infected adolescents and over 1000 at-risk adolescents who are 12-24 years of age available to approach for enrollment into intervention trials aimed at the prevention of HIV, primary prevention In at-risk and secondary and tertiary prevention in the HIV-infected, pre-adolescents, adolescents, and young adults. BCM proposes unique studies involving innovative use of technology for secondary prevention of HIV transmission and adherence to HIV medication regimens among youth, a study of the pharmacokinetics to evaluate interactions of antidepressants when used with antiretroviral medications in HIV-infected youth, and a study that evaluates linkage to care for youth identified as HIV-infected through a large, youth oriented community testing event sponsored by the city health department and a community based AIDS organization. BCM ATU has the clinical, behavioral and research capacities and linkages to community to participate in multiple trials aimed at prevention of HIV in youth and trials aimed at improvements in management and psychosocial functioning of HIV-infected youth. RELEVANCE: Youth in Houston and surrounding counties have one of the fastest growing rates of HIV-infection in the United States. Baylor College of Medicine (BCM)'s application to become an Adolescent Medicine Trials Unit is relevant to public health in that BCM plans to implement trials designed to promote primary prevention in HIV at-risk and secondary and tertiary prevention in HIV-infected youth.

描述（由申请人提供）：贝勒医学院（BCM）响应NIH RFA-HD-10-015艾滋病毒/艾滋病干预青少年医学试验网络，正在申请青少年医学试验单元（ATU）。BCM试验股计划通过提供一个经验丰富的研究团队来规划、登记、分析和发表研究试验的结果，包括行为研究、社区需求评估和治疗试验，同时满足艾滋病毒感染青年的临床和行为需求，从而为ATN的研究议程作出贡献。BCM ATU将有三个患者资源：1)德克萨斯州儿童医院（TCH）的青少年诊所，由Paul博士和Schwarzwald博士领导，分别为BCM儿科的过敏和免疫科和逆转录病毒学科；2) Thomas Street Clinic （TSC）由Dr Schwarzwald领导的hiv感染青年诊所；3)项目医疗家庭诊所，在休斯敦医疗服务不足的地区提供青少年护理，由BCM儿科的Desiree Evans博士领导。BCM将有225名感染艾滋病毒的青少年和1000多名12-24岁的高危青少年参加干预试验，目的是预防艾滋病毒，在高危人群中进行初级预防，在艾滋病毒感染者、青少年前期、青少年和年轻人中进行二级和三级预防。BCM建议进行一些独特的研究，包括创新性地使用技术，在青少年中预防艾滋病毒传播和遵守艾滋病毒药物治疗方案；开展一项药物动力学研究，以评估在感染艾滋病毒的青少年中使用抗抑郁药与抗逆转录病毒药物时的相互作用；由市卫生部门和社区艾滋病组织主办的面向青年的社区检测活动。BCM - ATU具有临床、行为和研究能力，并与社区有联系，参与旨在预防青年感染艾滋病毒的多项试验，以及旨在改善感染艾滋病毒青年的管理和心理社会功能的试验。