Baylor College of Medicine Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

摘要贝勒医学院 包括休斯顿市在内的哈里斯县是美国48个县之一。在……里面 其中超过50%的新艾滋病毒诊断发生在。迫切需要创新和 年青少年和青壮年艾滋病毒治疗和预防(Aya)的协作新方法 休斯敦。这项研究的长期目标是使美国和休斯顿地区更接近于结束艾滋病毒 通过解决在阿亚成功预防和治疗艾滋病毒所涉及的问题，加强对艾滋病毒流行病的认识。这些目标 与青少年试验网络(ATN)研究目标和休斯顿联盟合作伙伴关系保持一致 允许在阿亚开展ATN的所有五个优先领域的研究：改进艾滋病毒检测、预防 新的感染，让青年参与护理，提高治疗和治疗效果，并减少 新冠肺炎导致的艾滋病毒不良健康后果。作为一个网站，我们计划实现以下具体目标 阿亚的艾滋病毒护理、研究和预防。目标1-进行ATN确定的ATN的试验 执行委员会(EC)和科学领导委员会(SLC)：贝勒医学院 ATN网站有一个长期的研究单位，拥有与Aya合作多年的工作人员，两人都在 临床试验环境和社区中，艾滋病毒携带者或有感染艾滋病毒风险的人。目标2- 参与试验的开发：BCM的ATN项目负责人和员工具有多年的 在Aya和SO开发和进行临床试验将与ATN业务部门合作 和协作中心(OCC)来开发和实施在ATN中进行的试验。此外，BCM 青年社区咨询委员会(YCAB)，其成员一直活跃在ATN青年 咨询委员会(YAC)和国家CAB，青年专家和健康倡导者(ATN-YES)将评估 并为开展研究提供投入，为未来的研究提供和加强想法。目标3--提供 关于成功招募和注册参与者的创新：作为ATN站点联盟，我们 具有结构、经验和外展能力，能够在多个层面上实现这一目标，并在 覆盖Aya，包括种族和性别少数群体和无家可归的青年。AIM 4-提供站点(德克萨斯儿童 医院和哈里斯健康西北和托马斯街健康中心)以及在 休斯顿ATN联盟、当地实验室能力和药房支持，以进行ATN试验 与OCC合作。目标5--继续评估和调整休斯顿协作区 在ATN中反映的有意义和持续的社区参与的联盟领导模式 低体重或高风险人群的研究性研究参与。我们预料到改进的预期结果 在艾滋病毒感染和预防的连续不断的每个ATN优先领域。这个项目影响很大 因为它将为受影响的阿亚社区提供必要的财团，该社区位于 美国与OCC合作，在实现ATN目标方面取得可持续进展。

ABSTRACT Baylor College of Medicine Harris County, which includes the City of Houston, is among the 48 counties in the United States (U.S.) in which more than 50 percent of new HIV diagnoses occur. There is an urgent need for innovative and collaborative new approaches to HIV treatment and prevention in adolescents and young adults (AYA) in Houston. The long-term goal of this research is to move the U.S. and Houston area closer to ending the HIV epidemic by addressing the issues involved in successful prevention and treatment of HIV in AYA. These goals align with Adolescent Trials Network (ATN) research objectives and Houston Consortium partnerships will allow research to be conducted in AYA in all five priority areas of the ATN: improving HIV testing, preventing new infections, engaging youth in care, improving treatment and treatment effectiveness, and reducing adverse HIV health outcomes due to COVID-19. We plan to accomplish the following specific aims as a site for HIV care, research, and prevention in AYA. Aim 1 – Conduct the Trials of the ATN as identified by the ATN Executive Committee (EC) and Scientific Leadership Committee (SLC): Baylor College of Medicine (BCM) ATN site has a longstanding research unit with staff with years of experience working with AYA, both in a clinical trials settings and in the community, who are living with HIV (LWH) or are at risk for HIV. Aim 2 – Participate in the Development of Trials: BCM's ATN Project Lead and staff have years of experience in development and conducting of clinical trials in AYA and so will work in collaboration with the ATN Operations and Collaborations Center (OCC) to develop and conduct the trials performed in the ATN. In addition, the BCM Youth Community Advisory Board, (YCAB), which has had members who have been active in the ATN Youth Advisory Council (YAC) and National CAB, Youth Experts and Advocates for Health (ATN-YEAH), will evaluate and provide input on developing studies and provide and enhance ideas for future studies. Aim 3 – Provide Innovation Regarding Successful Recruitment and Enrollment of Participants: As an ATN Site Consortium, we have the structure, experience, and outreach to approach this aim at multiple levels with outreach in hard-to- reach AYA including racial and gender minority and homeless youth. Aim 4 – Provide Sites (Texas Children's Hospital and Harris Health Northwest and Thomas Street Health Center) as well as outreach within the Houston ATN Consortium, local laboratory capacity, and pharmacy support in order to conduct the ATN trials in collaboration with the OCC. Aim 5 – Continued evaluation and adjustment of Houston collaborative consortium leadership model for meaningful and continued community engagement as reflected in ATN research study participation of AYA at risk for or LWH. We anticipate the expected outcomes of improvements in each ATN priority area along the continuums of HIV infection and prevention. This project is high impact because it will provide the necessary consortium in impacted communities of AYA in a high-priority region of the U.S. to collaborate with the OCC to make sustainable progress in reaching the ATN goals.