Integrative Imaging Core (IIC)

查看、测量和记录生物样本或生物体行为的特征的能力是科学调查的核心。综合成像核心(IIC)的总体目标是提供熟练和知识渊博的员工，将最先进的基于成像的技术应用于KIDDRC研究项目。 HC是系统进化的产物，致力于满足KIDDRC研究人员的成像需求。 它最初成立于1978年，是一个组织学核心，1990年发展和扩展到包括图像分析，1997年随着数字成像的出现而得到加强，并于2002年纳入了微阵列功能。该核心在2007年经历了一次转变，当时它转移到了海门威生命科学创新中心(HLSIC)专门为HC设计的空间，并获得了超过300万美元的主要设备。内务委员会 随着与霍格伦德脑成像中心(HBIC)建立正式合作伙伴关系，这一限制将不断发展。 HC将各种资源整合到一个包中，有一个共同的主线，即它们都基于结合或支持成像技术的方法(毕竟，微阵列扫描仪与花哨的共焦显微镜相差不多)。我们试图将这些技术整合为一个连续体；从分子到细胞，再到整个生物体，许多KIDDRC项目都包含了这一限制的全部或部分。这个 通过提供集中化和一站式购物，HC的垂直集成促进了这些技术的访问和协调，并鼓励Pls采用多学科方法来研究问题。

The ability to view, measure and record characteristics of biological samples or an organism's behavior lies at the heart of scientific investigation. The overall objective ofthe Integrative Imaging Core (IIC) is to provide skilled and knowledgeable staff to apply state-of-the-art imaging-based technologies to KIDDRC research programs. HC is the product of systematic evolution devoted to meeting the imaging needs of KIDDRC investigators. Originally established in 1978 as a histology core, it evolved and expanded to incorporate image analysis in 1990, was enhanced with the advent of digital imaging in 1997, and incorporated microarray capabilifies in 2002. The core underwent a transformation in 2007 when it moved to space designed specifically for the HC in the Hemenway Life Sciences Innovation Center (HLSIC) and received over $3M for major equipment. The HC confinues to evolve with the establishment of a formal partnership with the Hoglund Brain Imaging Center (HBIC). HC incorporates into one package a variety of resources with the common thread that they are all based on approaches that incorporate or support imaging technologies (a microarray scanner is, after all, little more than a fancy confocal microscope). We have attempted to integrate these technologies as a continuum; from molecule to cell to whole organism, and many KIDDRC programs embrace all or a part of this confinuum. The vertical integration of HC facilitates access and coordination of these technologies by providing centralization and one-stop shopping, and encourages Pls to adopt multidisciplinary approaches to research problems.