Development of a preclinical optical frequency domain angiography instrument

临床前光频域血管造影仪的研制

基本信息

  • 批准号:
    8221601
  • 负责人:
  • 金额:
    $ 46.48万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-05-04 至 2017-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Tumor-induced angiogenesis plays a central role in the progression of tumors to malignancy, provides the critical transport of blood-born therapies into the tumor space, and supplies oxygen to effectuate oxygen-dependent radiological and light-based therapies. Pre-clinical research in tumor angiogenesis and tumor microvascular function has traditionally relied on histological methods, which suffer from well-known limitations, or fluorescence-based confocal and multiphoton microscopy, which provide high- resolution three-dimensional mapping of multiple parameters but support imaging over limited fields of view and depths of penetration. By contrast, optical coherence tomography approaches support a relatively larger field of view and depth of penetration and have the potential, if translated into the biological laboratory, to reveal critical and previously hidden aspects of the tumor microvasculature. In our laboratory, we have demonstrated the principles of a unique preclinical optical imaging technology that will be a powerful tool for investigating blood vessels and the biological microenvironment in vivo. The technology, optical frequency domain angiography (OFDA), supports high- resolution three-dimensional imaging similar to multiphoton and confocal microscopy. In this proposal, we propose optical, engineering, computational, and software solutions that will be required to realize a practical and robust OFDA instrument for translation into the biological laboratory. Our approach will unite investigators and resources at the Massachusetts General Hospital (MGH) and Physical Sciences, Incorporated (PSI). Innovations to the OFDA instrumentation and core algorithms will be performed by the MGH team, while construction of the computational hardware and software that is needed to improve processing will be performed by the PSI team. Our goal is to move OFDA technology from the engineering to the biological laboratory, which may catalyze research into basic cancer biology and cancer therapeutics. PUBLIC HEALTH RELEVANCE: In nearly all aspects of cancer biology and cancer therapeutics, the tumor microvasculature plays a significant role, and preclinical imaging tools are invaluable in investigations of the tumor microvasculature. In this grant, we propose to develop a preclinical optical frequency domain angiography instrument and deliver it to the biological investigator.
描述(由申请人提供):肿瘤诱导的血管生成在肿瘤向恶性发展的过程中起着核心作用,提供了血源性治疗进入肿瘤空间的关键运输,并为实现依赖氧的放射和光基治疗提供氧气。肿瘤血管生成和肿瘤微血管功能的临床前研究传统上依赖于组织学方法,这种方法存在众所周知的局限性,或者基于荧光的共聚焦和多光子显微镜,这些方法提供了多个参数的高分辨率三维映射,但支持在有限的视野和穿透深度下进行成像。相比之下,光学相干断层扫描方法支持相对较大的视野和穿透深度,如果转化为生物实验室,则有可能揭示肿瘤微血管系统的关键和以前隐藏的方面。在我们的实验室里,我们已经展示了一种独特的临床前光学成像技术的原理,这将是研究血管和体内生物微环境的有力工具。该技术,光学频域血管造影(OFDA),支持类似于多光子和共聚焦显微镜的高分辨率三维成像。在本提案中,我们提出了光学、工程、计算和软件解决方案,这些解决方案将需要实现一个实用而强大的OFDA仪器,以便转化为生物实验室。我们的方法将联合麻省总医院(MGH)和物理科学公司(PSI)的研究人员和资源。OFDA仪器和核心算法的创新将由MGH团队进行,而改进处理所需的计算硬件和软件的构建将由PSI团队进行。我们的目标是将OFDA技术从工程应用转移到生物实验室,这可能会促进基础癌症生物学和癌症治疗学的研究。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Benjamin James Vakoc其他文献

Benjamin James Vakoc的其他文献

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{{ truncateString('Benjamin James Vakoc', 18)}}的其他基金

Novel optical coherence tomography tool development for quantitative peripheral nerve imaging
用于定量周围神经成像的新型光学相干断层扫描工具开发
  • 批准号:
    9926501
  • 财政年份:
    2019
  • 资助金额:
    $ 46.48万
  • 项目类别:
Novel optical coherence tomography tool development for quantitative peripheral nerve imaging
用于定量周围神经成像的新型光学相干断层扫描工具开发
  • 批准号:
    10225151
  • 财政年份:
    2018
  • 资助金额:
    $ 46.48万
  • 项目类别:
Development of a preclinical optical frequency domain angiography instrument
临床前光频域血管造影仪的研制
  • 批准号:
    8466296
  • 财政年份:
    2012
  • 资助金额:
    $ 46.48万
  • 项目类别:
Development of a preclinical optical frequency domain angiography instrument
临床前光频域血管造影仪的研制
  • 批准号:
    8630869
  • 财政年份:
    2012
  • 资助金额:
    $ 46.48万
  • 项目类别:
TRD2: Circular Ranging OCT
TRD2:圆形测距 OCT
  • 批准号:
    10494622
  • 财政年份:
    2011
  • 资助金额:
    $ 46.48万
  • 项目类别:
TRD2: Circular Ranging OCT
TRD2:圆形测距 OCT
  • 批准号:
    10650839
  • 财政年份:
    2011
  • 资助金额:
    $ 46.48万
  • 项目类别:
Image-Guided Laser Therapy for Barrett's Esophagus
巴雷特食管的图像引导激光治疗
  • 批准号:
    7249110
  • 财政年份:
    2007
  • 资助金额:
    $ 46.48万
  • 项目类别:
Image-Guided Laser Therapy for Barrett's Esophagus
巴雷特食管的图像引导激光治疗
  • 批准号:
    8058796
  • 财政年份:
    2007
  • 资助金额:
    $ 46.48万
  • 项目类别:
Image-Guided Laser Therapy for Barrett's Esophagus
巴雷特食管的图像引导激光治疗
  • 批准号:
    7414599
  • 财政年份:
    2007
  • 资助金额:
    $ 46.48万
  • 项目类别:
Image-Guided Laser Therapy for Barrett's Esophagus
巴雷特食管的图像引导激光治疗
  • 批准号:
    7608655
  • 财政年份:
    2007
  • 资助金额:
    $ 46.48万
  • 项目类别:
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