TRD2: Circular Ranging OCT

TRD2：圆形测距 OCT

• 批准号: 10650839
• 负责人: Benjamin James Vakoc
• 金额: $ 32.06万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-21 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650839
• 关键词: Accidental Injury; Address; Algorithms; Alzheimer’s disease biomarker; Angiography; Architecture; Blood Vessels; Blood flow; CYP1A2 gene; Cardiac; Clinical Management; Clinical Research; Collaborations; Communities; Data; Diabetic Retinopathy; Diagnostic Imaging; Disease; Equipment; Eye; Flowmetry; Forehead; Fright; Functional Imaging; Funding; Head; Head and neck structure; Human; Image; Image-Guided Surgery; Imaging Device; Industry; Investigation; Light; Lymphangiography; Maps; Methods; Microscope; Morbidity - disease rate; Nerve; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Patients; Perfusion; Peripheral; Peripheral Nerves; Physiologic pulse; Positioning Attribute; Procedures; Research; Research Personnel; Retina; Retinal Diseases; Retinopathy of Prematurity; Scientist; Source; Speed; Surgeon; Surveys; System; Techniques; Technology; Thyroidectomy; Time; Tissues; Translations; United States National Institutes of Health; Update; Vagus nerve structure; Visualization; Work; contrast enhanced; design; early detection biomarkers; first-in-human; frequency comb; imaging platform; imaging system; implantation; improved; innovation; innovative technologies; instrument; novel; novel strategies; prevent; programs; retinal imaging; routine imaging; systems research; technological innovation; tool; translational impact; vascular bed

Project Summary TRD-2 TRD project 2 will develop imaging platforms based on novel circular ranging (CR) architectures of optical coherence tomography. Specific Aim #1 addresses long-standing challenges to using OCT in open surgery. Conventional approaches burdened the surgeon with cumbersome equipment and required disruptions in workflow. We will leverage the depth-independence of CR to enable a head-mounted OCT microscope that can continuously survey the surgical field. This OCT loupe platform will be specifically developed to provide improved visualization of nerves to prevent accidental injury to these delicate and critical tissues, and thereby avoiding some of the most feared surgical morbidities. Specific Aim #2 integrates recent advancements in quantitative flow imaging with extremely rapid retinal CR-OCT technology to enable a platform for wide-field angiography and quantitative flow mapping in the human retina. Quantitative flow imaging will enable comprehensive, pulse resolved maps of the non-capillary retinal vascular networks, positioning investigators to decipher the interaction of retinal perfusion and disease. Wide-field angiography will reduce barriers that have limited clinicians and scientists from reliably and routinely imaging the peripheral retina Through these aims, TRD-2 will develop, validate, and deliver innovative technologies to our collaborating investigators and to the broader biomedical community.

项目摘要 TRD-2 TRD项目2将开发基于新型光学环形测距（CR）架构的成像平台。 相干断层扫描具体目标#1解决了开放手术中使用OCT的长期挑战。 传统的方法使外科医生背负着笨重的设备，并且需要中断手术。 工作流我们将利用CR的深度独立性来实现头戴式OCT显微镜， 可连续观察术野。该OCT放大镜平台将专门开发，以提供 改善神经的可视化，以防止对这些脆弱和关键组织的意外伤害，从而 避免一些最可怕的外科疾病。具体目标#2整合了以下方面的最新进展 利用快速视网膜CR-OCT技术进行定量血流成像， 血管造影术和定量血流图在人类视网膜。定量血流成像将使 非毛细血管视网膜血管网络的全面、脉冲分辨地图，定位研究者， 解读视网膜灌注和疾病的相互作用。宽视野血管造影术将减少 限制临床医生和科学家可靠且常规地对周边视网膜进行成像通过这些目标， TRD-2将开发、验证并向我们的合作研究人员和 更广泛的生物医学社区。