Neurodevelopmental Effects of Early Life Arsenic Exposure

生命早期砷暴露对神经发育的影响

• 批准号: 8282814
• 负责人: Maitreyi Mazumdar
• 金额: $ 14.31万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8282814
• 关键词: Adult; Affect; Age; Age-Months; Area; Argentina; Arsenic; Auditory Brainstem Responses; Australia; Award; Bangladesh; Biometry; Birth; Boston; Characteristics; Child; Childhood; Chile; China; Chronic; Clinic; Clinical Research; Cohort Studies; Communities; Country; Cross-Sectional Studies; Data; Development; Development Plans; Diabetes Mellitus; Educational process of instructing; Elements; Environmental Epidemiology; Environmental Health; Environmental Pollution; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Evaluation; Exposure to; Failure; Fellowship; Foundations; Functional disorder; Goals; Guidelines; Hair; Head circumference; Health; Health Surveys; Hearing; India; Infant; Instruction; Investigation; Life; Link; Measures; Mentors; Mentorship; Metals; Mexico; Microcephaly; Mongolia; Mothers; Motor; Nervous System Trauma; Neurodevelopmental Disorder; Neurologic; Neurology; Outcome; Participant; Pediatric Hospitals; Peripheral Vascular Diseases; Poisoning; Population; Principal Investigator; Public Health Schools; Recording of previous events; Recruitment Activity; Reporting; Reproductive Health; Research; Research Personnel; Risk; Risk Assessment; Role; School-Age Population; Skin Cancer; Structure; Structure of nail of toe; Taiwan; Thailand; Toxic effect; Toxicology; United States; Vietnam; Water; Work; World Health Organization; career; career development; cohort; design; didactic education; drinking water; early childhood; early life exposure; experience; hearing impairment; high risk; high risk drinking; improved; infancy; instructor; interest; medical schools; meetings; method development; nervous system disorder; neurocognitive test; neurodevelopment; patient oriented research; population based; prenatal; professor; programs; prospective; reproductive; research and development; skin lesion; water sampling/testing

Dr. Maitreyi Mazumdar is Assistant In Neurology at Children's Hospital Boston and Instructor In Neurology at Harvard Medical School. The candidate's long-term goal is to develop an Independent research career focusing on the role of environmental contaminants in the development of neurological Injury and disease In children. Dr. Mazumdar's Interests in this field developed during her Fellowship in neurodevelopmental toxicology, when she became aware of Investigations of the effects of environmental arsenic exposure on children in Bangladesh. The proposed career development plan incorporates a multl-disclplinary program designed to provide an Intense, closely mentored, patient-oriented research experience, associated with a comprehensively structured didactic curriculum In environmental epidemiology, exposure assessment, advanced biostatistics, andriskassessment. Under the mentorship of Dr. David Christiani, Professor of Environmental Health at the Harvard School of Public Health, the candidate will investigate the effect of prenatal and eariy childhood arsenic exposure on neurodevelopment of children In Bangladesh, a country with high levels of arsenic contamination In groundwater. This research will examine epidemiological associations of arsenic exposure with measures of neurological development In infants and children, including 1) head circumference, 2) hearing impairment, 3) motor dysfunction, and 4) formal neurocognitive testing. The studies will be conducted in a cohort of 600 infants who are participating In a current study of reproductive health effects of arsenic. Additional children between the ages of 12 and 24 months wlll also be recruited neurodevelopmental assessment. The superb clinical, research, and teaching facilities of Children's Hospital Boston, Harvard Medical School, and the Harvard School of Public Health will support Dr. Mazumdar in meeting the objectives of her career development and research plans. RELEVANCE (See instructions): Studies have linked chronic exposure to arsenic with adverse health outcomes in adults, but its effect on children is unknown. The proposed work will examine the neurodevelopmental effects of prenatal and eariy- life arsenic exposure on Infants and young children in Bangladesh, an area with extremely high groundwater arsenic concentrations. Findings from this work will directly inform ongoing environmental risk assessment.

Maitreyi Mazumdar博士是波士顿儿童医院的神经病学助理， 哈佛医学院。候选人的长期目标是发展独立的研究事业 专注于环境污染物在神经损伤和疾病发展中的作用， 孩子Mazumdar博士在神经发育学研究期间对该领域产生了兴趣。 毒理学，当她意识到环境砷暴露的影响， 孟加拉国的儿童。拟议的职业发展计划包括一个多学科的计划 旨在提供一个激烈的，密切指导，以病人为导向的研究经验，与一个 在环境流行病学、接触评估、 先进的生物统计学，生物评估。在大卫Christiani博士的指导下， 在哈佛公共卫生学院的环境卫生专业，候选人将调查 产前和儿童早期砷暴露对孟加拉国儿童神经发育的影响 地下水砷污染严重这项研究将研究流行病学 砷暴露与婴儿和儿童神经发育指标的关系， 包括1）头围，2）听力障碍，3）运动功能障碍，和4）正式的神经认知 试验.这些研究将在600名婴儿的队列中进行，这些婴儿正在参与目前的一项研究， 砷对生殖健康的影响年龄在12至24个月之间的其他儿童也将被 神经发育评估。一流的临床，研究和教学设施， 波士顿儿童医院，哈佛医学院和哈佛公共卫生学院将支持博士。 Mazumdar在满足她的职业发展和研究计划的目标。 相关性（参见说明）： 研究表明，长期接触砷与成年人的不良健康结果有关， 孩子是未知的。这项拟议中的工作将研究产前和早期的神经发育影响- 孟加拉国地下水含量极高地区婴幼儿的砷暴露 砷浓度。这项工作的结果将直接为正在进行的环境风险评估提供信息。