生命早期砷暴露对神经发育的影响-猫眼课题宝

生命早期砷暴露对神经发育的影响

批准号：

7923256

负责人：

Maitreyi Mazumdar

金额：

$14.98万

依托单位：

BOSTON CHILDREN'S HOSPITAL

依托单位国家：

美国

项目类别：

财政年份：

2009

资助国家：

美国

项目状态：

已结题

起止时间：

2009-09-01 至 2014-05-31

来源：

https://reporter.nih.gov/project-details/7923256

关键词：

Affect Age Age-Months Area Argentina Arsenic Auditory Brainstem Responses Australia Award Bangladesh Biometry Birth Boston Characteristics Child Chile China Chronic Clinic Clinical Research Cohort Studies Communities Country Cross-Sectional Studies Data Development Development Plans Diabetes Mellitus Disease Educational Curriculum Educational process of instructing Elements Environmental Epidemiology Environmental Health Environmental Pollution Environmental Risk Factor Epidemiologic Studies Epidemiology Evaluation Exposure to Failure Fellowship Foundations Functional disorder Goals Guidelines Hair Head circumference Health Health Surveys Hearing India Infant Investigation Life Link Measures Mentors Mentorship Metals Mexico Microcephaly Mongolia Mothers Motor Nervous System Trauma Neurodevelopmental Disorder Neurologic Neurology Outcome Participant Pediatric Hospitals Peripheral Vascular Diseases Poisoning Population Principal Investigator Public Health Schools Recording of previous events Recruitment Activity Reporting Reproductive Health Research Research Personnel Risk Risk Assessment Role School-Age Population Skin Cancer Structure Structure of nail of toe Taiwan Thailand Toxic effect Toxicology United States Vietnam Water Work World Health Organization career career development cohort design drinking water early childhood early life exposure experience hearing impairment high risk high risk drinking improved infancy instructor interest medical schools meetings method development neurocognitive test neurodevelopment patient oriented research population based prenatal professor programs prospective reproductive skin lesion water sampling/testing

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DESCRIPTION (provided by applicant) Dr. Maitreyi Mazumdar is an Assistant in Neurology at Children's Hospital Boston and Instructor in Neurology at Harvard Medical School. The candidate's long-term goal is to develop an independent research career focusing on the role of environmental contaminants in the development of neurological Injury and disease in children. Dr. Mazumdar's interests in this field developed during her Fellowship in neurodevelopmental toxicology, when she became aware of investigations of the effects of environmental arsenic exposure on children in Bangladesh. The proposed Career Development Plan incorporates a multi-disciplinary program designed to provide an intense, closely mentored, patient-oriented research experience, associated with a comprehensively structured didactic curriculum in environmental epidemiology, exposure assessment, advanced biostatistics, and risk assessment. Under the mentorship of Dr. David Christiani, Professor of Environmental Health at the Harvard School of Public Health, the candidate will investigate the effect of prenatal and early childhood arsenic exposure on neurodevelopment of children in Bangladesh, a country with high levels of arsenic contamination in groundwater. This research will examine epidemiological associations of arsenic exposure with measures of neurological development In infants and children, including 1) head circumference, 2) hearing impairment, 3) motor dysfunction, and 4) formal neurocognitive testing. The studies will be conducted in a cohort of 600 infants who are participating in a current study of reproductive health effects of arsenic. Additional children between the ages of 12 and 24 months will also be recruited neurodevelopmental assessment. The superb clinical, research, and teaching facilities of Children's Hospital Boston, Harvard Medical School, and the Harvard School of Public Health will support Dr. Mazumdar in meeting the objectives of her career development and research plans.

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